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公开(公告)号：US09133504B2
公开(公告)日：2015-09-15
申请号：US11758621
申请日：2007-06-05
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6818 , C12Q2565/501 , C12Q2565/101 , C12Q2561/113
摘要： This invention provides methods and systems for measuring the binding of analytes in solution to probes bound to surfaces in real-time. The method involves contacting a fluid volume having a plurality of different analytes with a solid substrate having a plurality of different probes. The probes are capable of specifically binding to the analytes. The method also involves measuring signals at multiple time points while the fluid volume is in contact with the substrate. The signals measured at multiple time points can be correlated with the amount of binding of the analytes with the probes. The method eliminates the need to wash the probes before measuring the binding characteristics.
摘要翻译： 本发明提供了用于测量溶液中分析物与实际上与表面结合的探针的结合的方法和系统。 该方法包括将具有多个不同分析物的流体体积与具有多个不同探针的固体基质接触。 探针能够特异性地结合分析物。 该方法还涉及在流体体积与基底接触时在多个时间点测量信号。 在多个时间点测量的信号可以与分析物与探针的结合量相关。 该方法消除了在测量结合特性之前洗涤探针的需要。
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公开(公告)号：US09458497B2
公开(公告)日：2016-10-04
申请号：US13240603
申请日：2011-09-22
申请人： Arjang Hassibi , Babak Hassibi , Haris Vikalo
发明人： Arjang Hassibi , Babak Hassibi , Haris Vikalo
CPC分类号： C12Q1/6851 , C12Q1/686 , G01N21/6408 , G01N21/6428 , G01N2021/6432 , G01N2021/6439 , C12Q2565/519 , C12Q2561/113
摘要： This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample.
摘要翻译： 本发明提供了用于测量样品中多个核酸序列浓度的方法和系统。 在核酸探针阵列的存在下，例如使用聚合酶链反应（PCR）同时扩增样品中的核酸序列。 可以使用实时微阵列在每个循环期间或之后实时测量与多个核酸序列相对应的扩增子的量。 所测量的扩增子的量可用于确定样品中核酸序列的原始量。
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公开(公告)号：US20120077692A1
公开(公告)日：2012-03-29
申请号：US13240603
申请日：2011-09-22
申请人： Arjang Hassibi , Babak Hassibi , Haris Vikalo
发明人： Arjang Hassibi , Babak Hassibi , Haris Vikalo
CPC分类号： C12Q1/6851 , C12Q1/686 , G01N21/6408 , G01N21/6428 , G01N2021/6432 , G01N2021/6439 , C12Q2565/519 , C12Q2561/113
摘要： This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample.
摘要翻译： 本发明提供了用于测量样品中多个核酸序列浓度的方法和系统。 在核酸探针阵列的存在下，例如使用聚合酶链反应（PCR）同时扩增样品中的核酸序列。 可以使用实时微阵列在每个循环期间或之后实时测量与多个核酸序列相对应的扩增子的量。 所测量的扩增子的量可用于确定样品中核酸序列的原始量。
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公开(公告)号：US20080039339A1
公开(公告)日：2008-02-14
申请号：US11758621
申请日：2007-06-05
申请人： Arjang Hassibi , Babak Hassibi , Haris Vikalo , Jose Riechmann
发明人： Arjang Hassibi , Babak Hassibi , Haris Vikalo , Jose Riechmann
CPC分类号： C12Q1/6837 , C12Q1/6818 , C12Q2565/501 , C12Q2565/101 , C12Q2561/113
摘要： This invention provides methods and systems for measuring the binding of analytes in solution to probes bound to surfaces in real-time.
摘要翻译： 本发明提供了用于测量溶液中分析物与实际上与表面结合的探针的结合的方法和系统。
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5.发明授权Method and apparatus for detection, identification and quantification of single-and multi-analytes in affinity-based sensor arrays 有权用于基于亲和力的传感器阵列中单分子和多分析物的检测，鉴定和定量的方法和装置公开(公告)号：US09223929B2
公开(公告)日：2015-12-29
申请号：US11376398
申请日：2006-03-14
申请人： Babak Hassibi , Haris Vikalo , Arjang Hassibi
发明人： Babak Hassibi , Haris Vikalo , Arjang Hassibi
IPC分类号： G06F7/60 , G01N33/48 , G01N31/00 , G01N33/50 , G06F19/20 , G06F19/12 , G06F19/24 , G06F19/22
摘要： The disclosure provides methods, device, and systems for analyzing biological array data. In particular, the disclosure provides methods and computer implemented techniques for reducing interference in microarray data, and exploiting it to obtain more accurate readouts.
摘要翻译： 本公开提供用于分析生物阵列数据的方法，装置和系统。 具体地，本公开提供了用于减少微阵列数据干扰的方法和计算机实现的技术，并利用它们获得更准确的读出。
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公开(公告)号：US08048626B2
公开(公告)日：2011-11-01
申请号：US11829861
申请日：2007-07-27
申请人： Arjang Hassibi , Babak Hassibi , Haris Vikalo
发明人： Arjang Hassibi , Babak Hassibi , Haris Vikalo
CPC分类号： C12Q1/6851 , C12Q1/686 , G01N21/6408 , G01N21/6428 , G01N2021/6432 , G01N2021/6439 , C12Q2565/519 , C12Q2561/113
摘要： This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample.
摘要翻译： 本发明提供了用于测量样品中多个核酸序列浓度的方法和系统。 在核酸探针阵列的存在下，例如使用聚合酶链式反应（PCR）同时扩增样品中的核酸序列。 可以使用实时微阵列在每个循环期间或之后实时测量与多个核酸序列相对应的扩增子的量。 所测量的扩增子的量可用于确定样品中核酸序列的原始量。
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公开(公告)号：US20080176757A1
公开(公告)日：2008-07-24
申请号：US11829861
申请日：2007-07-27
申请人： Arjang Hassibi , Babak Hassibi , Haris Vikalo
发明人： Arjang Hassibi , Babak Hassibi , Haris Vikalo
CPC分类号： C12Q1/6851 , C12Q1/686 , G01N21/6408 , G01N21/6428 , G01N2021/6432 , G01N2021/6439 , C12Q2565/519 , C12Q2561/113
摘要： This invention provides methods and systems for measuring the concentration of multiple nucleic acid sequences in a sample. The nucleic acid sequences in the sample are simultaneously amplified, for example, using polymerase chain reaction (PCR) in the presence of an array of nucleic acid probes. The amount of amplicon corresponding to the multiple nucleic acid sequences can be measured in real-time during or after each cycle using a real-time microarray. The measured amount of amplicon produced can be used to determine the original amount of the nucleic acid sequences in the sample.
摘要翻译： 本发明提供了用于测量样品中多个核酸序列浓度的方法和系统。 在核酸探针阵列的存在下，例如使用聚合酶链反应（PCR）同时扩增样品中的核酸序列。 可以使用实时微阵列，在每个循环期间或之后实时测量与多个核酸序列相对应的扩增子的量。 所测量的扩增子的量可用于确定样品中核酸序列的原始量。
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8.发明申请Method and apparatus for detection, identification and quantification of single-and multi-analytes in affinity-based sensor arrays 有权用于基于亲和力的传感器阵列中单分子和多分析物的检测，鉴定和定量的方法和装置公开(公告)号：US20070099198A1
公开(公告)日：2007-05-03
申请号：US11376398
申请日：2006-03-14
申请人： Babak Hassibi , Haris Vikalo , Arjang Hassibi
发明人： Babak Hassibi , Haris Vikalo , Arjang Hassibi
摘要： The disclosure provides methods, device, and systems for analyzing biological array data. In particular, the disclosure provide methods and computer implemented techniques for reducing interference in microarray data, and exploiting it to obtain more accurate readouts
摘要翻译： 本公开提供用于分析生物阵列数据的方法，装置和系统。 具体地，本公开提供了用于减少微阵列数据干扰的方法和计算机实现的技术，并利用其获得更准确的读数
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