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公开(公告)号：US08629156B2
公开(公告)日：2014-01-14
申请号：US13290261
申请日：2011-11-07
申请人： Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
发明人： Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
IPC分类号： C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/18 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12 , A61K31/505 , A61P1/00
CPC分类号： C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要： Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译： 公开了式I和II的化合物，以及包含它们的组合物及其用于治疗，预防和控制5-羟色胺介导的疾病和障碍的方法：
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公开(公告)号：US20100280054A1
公开(公告)日：2010-11-04
申请号：US12750278
申请日：2010-03-30
申请人： Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
发明人： Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
IPC分类号： A61K31/505 , C07D239/47 , A61P1/00
CPC分类号： C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要： Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译： 公开了式I和II的化合物，以及包含它们的组合物及其用于治疗，预防和控制5-羟色胺介导的疾病和障碍的方法：
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公开(公告)号：US07723345B2
公开(公告)日：2010-05-25
申请号：US11638677
申请日：2006-12-12
申请人： Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人： Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号： A61K31/505 , C07D239/02
CPC分类号： C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要： Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译： 公开了式I和II的化合物，以及包含它们的组合物及其用于治疗，预防和控制5-羟色胺介导的疾病和障碍的方法：
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公开(公告)号：US20070191370A1
公开(公告)日：2007-08-16
申请号：US11638677
申请日：2006-12-12
申请人： Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
发明人： Arokiasamy Devasagayaraj , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
IPC分类号： A61K31/53 , A61K31/506 , A61K31/501 , A61K31/4965 , A61K31/497 , A61K31/4439 , C07D403/02
CPC分类号： C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要： Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译： 公开了式I和II的化合物，以及包含它们的组合物及其用于治疗，预防和控制5-羟色胺介导的疾病和障碍的方法：
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公开(公告)号：US20120157484A1
公开(公告)日：2012-06-21
申请号：US13290261
申请日：2011-11-07
申请人： Arokiasamy DEVASAGAYARAJ , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
发明人： Arokiasamy DEVASAGAYARAJ , Haihong Jin , Qingyun Liu , Brett Marinelli , Lakshama Samala , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Wenxue Wu , Chengmin Zhang , Haiming Zhang
IPC分类号： A61K31/505 , A61P1/00 , C07D401/04 , A61K31/506 , C07D239/47 , C07D239/42
CPC分类号： C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要： Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译： 公开了式I和II的化合物，以及包含它们的组合物及其用于治疗，预防和控制5-羟色胺介导的疾病和障碍的方法：
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公开(公告)号：US08063057B2
公开(公告)日：2011-11-22
申请号：US12750278
申请日：2010-03-30
申请人： Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人： Arokiasamy Devasagayaraj , Haihong Jin , Brett Marinelli , Lakshama Samala , Zhi Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号： A61K31/505 , C07D239/47 , A61P1/00
CPC分类号： C07D251/18 , C07B2200/07 , C07C229/36 , C07C229/42 , C07C229/44 , C07C275/42 , C07C311/29 , C07C2601/08 , C07D213/74 , C07D239/34 , C07D239/42 , C07D239/47 , C07D239/48 , C07D241/20 , C07D241/24 , C07D249/06 , C07D251/16 , C07D251/22 , C07D251/52 , C07D401/04 , C07D403/04 , C07D403/12 , C07D409/04 , C07D409/12 , C07D413/12
摘要： Compounds of formulae I and II are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and manage serotonin-mediated diseases and disorders:
摘要翻译： 公开了式I和II的化合物，以及包含它们的组合物及其用于治疗，预防和控制5-羟色胺介导的疾病和障碍的方法：
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7.发明授权4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use 有权4-苯基-6-（2,2,2-三氟-1-苯基乙氧基）嘧啶类化合物及其使用方法公开(公告)号：US08772482B2
公开(公告)日：2014-07-08
申请号：US13162989
申请日：2011-06-17
申请人： Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人： Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号： C07D403/12 , A61K31/506 , A61P1/04 , A61P1/06 , A61K31/4152
CPC分类号： A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
摘要翻译： 公开了式I化合物，以及包含它们的组合物及其用于治疗，预防和/或控制疾病和病症的方法：
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8.发明授权Methods of using 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds 有权使用4-苯基-6-（2,2,2-三氟-1-苯基乙氧基）嘧啶类化合物的方法公开(公告)号：US07968559B2
公开(公告)日：2011-06-28
申请号：US12754341
申请日：2010-04-05
申请人： Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人： Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号： A61K31/506 , A61P35/00 , A61P1/00 , C07D403/12
CPC分类号： A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
摘要翻译： 公开了式I化合物，以及包含它们的组合物及其用于治疗，预防和/或控制疾病和病症的方法：
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9.发明申请Methods of using 4-Phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-Based Compounds 有权使用4-苯基-6-（2,2,2-三氟-1-苯基乙氧基）嘧啶类化合物的方法公开(公告)号：US20100311764A1
公开(公告)日：2010-12-09
申请号：US12754341
申请日：2010-04-05
申请人： Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人： Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号： A61K31/506 , A61P1/00 , A61P35/00
CPC分类号： A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
摘要翻译： 公开了式I化合物，以及包含它们的组合物及其用于治疗，预防和/或控制疾病和病症的方法：
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10.发明授权4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds and methods of their use 有权4-苯基-6-（2,2,2-三氟-1-苯基乙氧基）嘧啶类化合物及其使用方法公开(公告)号：US07709493B2
公开(公告)日：2010-05-04
申请号：US12468974
申请日：2009-05-20
申请人： Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
发明人： Arokiasamy Devasagayaraj , Haihong Jin , Zhi-Cai Shi , Ashok Tunoori , Ying Wang , Chengmin Zhang
IPC分类号： C07D403/12 , A61K31/506 , A61P35/00
CPC分类号： A61K31/506 , A61K31/4152 , C07D239/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Compounds of formula I are disclosed, as well as compositions comprising them and methods of their use to treat, prevent and/or manage diseases and disorders:
摘要翻译： 公开了式I化合物，以及包含它们的组合物及其用于治疗，预防和/或控制疾病和病症的方法：
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