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1.发明授权Antibodies that recognize the 85P1B3 protein useful in treatment and detection of cancer 有权识别85P1B3蛋白的抗体可用于治疗和检测癌症公开(公告)号：US07217799B2
公开(公告)日：2007-05-15
申请号：US09942052
申请日：2001-08-28
申请人： Arthur B. Raitano , Mary Faris , Rene S. Hubert , Daniel E. Afar , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
发明人： Arthur B. Raitano , Mary Faris , Rene S. Hubert , Daniel E. Afar , Wangmao Ge , Pia M. Challita-Eid , Aya Jakobovits
CPC分类号： C07K14/47
摘要： A novel gene (designated 85P1B3) and its encoded protein are described. While 85P1B3 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 85P1B3 provides a diagnostic and/or therapeutic target for cancers. The 85P1B3 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.
摘要翻译： 描述了一种新型基因（命名为85P1B3）及其编码的蛋白质。 虽然85P1B3在正常成人组织中表现出组织特异性表达，但是在多种癌症中异常表达，如表1所示。因此，85P1B3为癌症提供了诊断和/或治疗靶点。 85P1B3基因或其片段或其编码的蛋白质或其片段可用于引发免疫应答。
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2.发明授权Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer 有权核酸和相应的标题为161P2F10B的蛋白质可用于治疗和检测癌症公开(公告)号：US08562989B2
公开(公告)日：2013-10-22
申请号：US13153336
申请日：2011-06-03
申请人： Aya Jakobovits , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Wangmao Ge , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Pia M. Challita-Eid
发明人： Aya Jakobovits , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Wangmao Ge , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Pia M. Challita-Eid
IPC分类号： A61K39/395
CPC分类号： C07K16/30 , A61K31/7088 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3061 , C07K16/3069 , C07K16/40 , C07K2317/20 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2319/30 , C12N9/16 , C12Q1/6886 , C12Q2600/158 , G01N33/57492 , Y02A50/466
摘要： A novel gene 0161P2F10B (also designated 161P2F10B) and its encoded protein, and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
摘要翻译： 描述了新颖的基因0161P2F10B（也称为161P2F10B）及其编码的蛋白质及其变体，其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，161P2F10B提供了诊断， 癌症的预后，预防和/或治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。
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3.发明授权Nucleic acid and corresponding protein entitled 193P1E1B useful in treatment and detection of cancer 失效核酸和相应的标题为193P1E1B的蛋白质可用于治疗和检测癌症公开(公告)号：US08188228B2
公开(公告)日：2012-05-29
申请号：US12763982
申请日：2010-04-20
申请人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Wangmao Ge , Aya Jakobovits
发明人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Wangmao Ge , Aya Jakobovits
IPC分类号： C07K5/10
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/34 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , Y02A50/466
摘要： A novel gene 0193P1E1B (also designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 193P1E1B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 193P1E1B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 193P1E1B can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因0193P1E1B（也称为193P1E1B）及其编码的蛋白质及其变体，其中193P1E1B在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，193P1E1B提供诊断， 癌症的预后，预防和/或治疗靶标。 193P1E1B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与193P1E1B反应的抗体或T细胞可用于主动或被动免疫。
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4.发明授权Nucleic acid and corresponding protein entitled 158P3D2 useful in treatment and detection of cancer 失效核酸和相应的标题为158P3D2的蛋白质可用于治疗和检测癌症公开(公告)号：US08039000B2
公开(公告)日：2011-10-18
申请号：US11483354
申请日：2006-07-06
申请人： Aya Jakobovits , Mary Faris , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Rene S. Hubert , Daniel E. H. Afar , Wangmao Ge , Arthur B. Raitano , Pia M. Challita-Eid
发明人： Aya Jakobovits , Mary Faris , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Rene S. Hubert , Daniel E. H. Afar , Wangmao Ge , Arthur B. Raitano , Pia M. Challita-Eid
IPC分类号： A61K39/395
CPC分类号： C07K14/4748 , A61K39/00 , Y02A50/466 , Y10T436/143333
摘要： A novel gene (designated 158P3D2) and its encoded protein, and variants thereof, are described wherein 158P3D2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 158P3D2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 158P3D2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 158P3D2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为158P3D2）及其编码的蛋白质及其变体，其中158P3D2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，158P3D2提供诊断，预后， 癌症的预防和/或治疗靶标。 158P3D2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与158P3D2反应的抗体或T细胞可用于主动或被动免疫。
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5.发明授权Nucleic acid and corresponding protein entitled 193P1E1B useful in treatment and detection of cancer 有权核酸和相应的标题为193P1E1B的蛋白质可用于治疗和检测癌症公开(公告)号：US07968099B2
公开(公告)日：2011-06-28
申请号：US12648854
申请日：2009-12-29
申请人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Wangmao Ge , Aya Jakobovits
发明人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Wangmao Ge , Aya Jakobovits
IPC分类号： A61K39/00
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/34 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , Y02A50/466
摘要： A novel gene (designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 193P1E1B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 193P1E1B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 191P1E1B can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（命名为193P1E1B）及其编码的蛋白质及其变体，其中193P1E1B在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，193P1E1B提供诊断，预后， 癌症的预防和/或治疗靶标。 193P1E1B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与191P1E1B反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20110150910A1
公开(公告)日：2011-06-23
申请号：US12686939
申请日：2010-01-13
申请人： Aya Jakobovits , Pia M. Challita-Eid , Mary Faris , Wangmao Ge , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Arthur B. Raitano , Daniel E. H. Afar
发明人： Aya Jakobovits , Pia M. Challita-Eid , Mary Faris , Wangmao Ge , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Arthur B. Raitano , Daniel E. H. Afar
CPC分类号： C07K14/47 , A61K47/646 , A61K47/6851 , A61K47/6901 , A61K51/1045
摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.
摘要翻译： 图中指定和阐述的新基因。 2及其各自编码的蛋白质及其变体，其中本发明的基因在正常成人组织中表现出组织特异性表达，并且在诸如表I所列的癌症中异常表达。因此， 基因 2提供癌症的诊断，预后，预防和/或治疗靶点。 图1的基因 2或其片段，其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与图1的基因产物反应的抗体或T细胞。 2可用于主动或被动免疫。
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7.发明授权Nucleic acid and corresponding protein entitled 193P1E1B useful in treatment and detection of cancer 失效核酸和相应的标题为193P1E1B的蛋白质可用于治疗和检测癌症公开(公告)号：US07659377B2
公开(公告)日：2010-02-09
申请号：US12206895
申请日：2008-09-09
申请人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Wangmao Ge , Aya Jakobovits
发明人： Arthur B. Raitano , Pia M. Challita-Eid , Mary Faris , Rene S. Hubert , Wangmao Ge , Aya Jakobovits
CPC分类号： C07K16/30 , A61K2039/505 , C07K2317/34 , C12Q1/6886 , C12Q2600/136 , C12Q2600/158 , Y02A50/466
摘要： A novel gene (designated 193P1E1B) and its encoded protein, and variants thereof, are described wherein 193P1E1B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 193P1E1B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 193P1E1B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 191P1E1B can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（命名为193P1E1B）及其编码的蛋白质及其变体，其中193P1E1B在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，193P1E1B提供诊断，预后， 癌症的预防和/或治疗靶标。 193P1E1B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与191P1E1B反应的抗体或T细胞可用于主动或被动免疫。
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8.发明授权Nucleic acid and corresponding protein entitled 161P5C5 useful in treatment and detection of cancer 失效核酸和相应的标题为161P5C5的蛋白质可用于治疗和检测癌症公开(公告)号：US07642342B2
公开(公告)日：2010-01-05
申请号：US11442031
申请日：2006-05-26
申请人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： C07H21/02
CPC分类号： C07K14/4748 , A61K39/00 , Y02A50/466 , Y10T436/143333
摘要： A novel gene (designated 161P5C5) and its encoded protein, and variants thereof, are described wherein 161P5C5 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table 1. Consequently, 161P5C5 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P5C5 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P5C5 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为161P5C5）及其编码的蛋白及其变体，其中161P5C5在正常成人组织中表现出组织特异性表达，并且在表1中列出的癌症中异常表达。因此，161P5C5提供诊断，预后， 癌症的预防和/或治疗靶标。 161P5C5基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P5C5反应的抗体或T细胞可用于主动或被动免疫。
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9.发明申请NUCLEIC ACID AND CORRESPONDING PROTEIN ENTITLED 213P1F11 USEFUL IN TREATMENT AND DETECTION OF CANCER 失效核酸和相关蛋白质213P1F11用于治疗和检测癌症公开(公告)号：US20090181891A1
公开(公告)日：2009-07-16
申请号：US12357253
申请日：2009-01-21
申请人： Pia M. CHALLITA-EID , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. CHALLITA-EID , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
CPC分类号： C07K14/82 , A01K2217/05 , A01K2267/0331
摘要： A novel gene (designated 213P1F11) and its encoded protein, and variants thereof, are described wherein 213P1F11 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 213P1F11 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 213P1F11 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 213P1F11 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为213P1F11）及其编码的蛋白及其变体，其中213P1F11在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，213P1F11提供诊断，预后， 癌症的预防和/或治疗靶标。 213P1F11基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与213P1F11反应的抗体或T细胞可用于主动或被动免疫。
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10.发明授权Nucleic acid and corresponding protein entitled 162P1E6 useful in treatment and detection of cancer 失效核酸和相应的蛋白质162P1E6可用于治疗和检测癌症公开(公告)号：US08497351B2
公开(公告)日：2013-07-30
申请号：US13043221
申请日：2011-03-08
申请人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia M. Challita-Eid , Arthur B. Raitano , Mary Faris , Rene S. Hubert , Karen Jane Meyrick Morrison , Robert Kendall Morrison , Wangmao Ge , Aya Jakobovits
IPC分类号： C07K5/00
CPC分类号： C07K14/4748 , A61K39/00 , Y02A50/466 , Y10T436/143333
摘要： A novel gene (designated 162P1E6) and its encoded protein, and variants thereof, are described wherein 162P1E6 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 162P1E6 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 162P1E6 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 162P1E6 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（命名为162P1E6）及其编码的蛋白质及其变体，其中162P1E6在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，162P1E6提供诊断，预后， 癌症的预防和/或治疗靶标。 162P1E6基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与162P1E6反应的抗体或T细胞可用于主动或被动免疫。
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