摘要:
Human EEF2K genes are identified as modulators of the PTEN/AKT pathway and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT comprising screening for agents that modulate the activity of EEF2K are provided.
摘要:
Human EEF2K genes are identified as modulators of the PTEN/AKT pathway and thus are therapeutic targets for disorders associated with defective PTEN/AKT function. Methods for identifying modulators of PTEN/AKT comprising screening for agents that modulate the activity of EEF2K are provided.
摘要:
A valet rod slide mounting assembly is provided for mounting to a supporting surface, such as a door, closet organizer, wall, or the like. The assembly includes a rod and a tube receiving the rod for sliding movement between an extended position and a retracted position when the tube overlaps substantially the rod. The assembly also includes at least two anchors for mounting the tube to the supporting surface. The anchors include a first bore sized to receive the tube and a second bore perpendicular to the first bore and sized to receive a mounting element that engages the support surface. The anchors can also include a third bore where a tube retainer is positioned to engage the tube securably. The assembly can also include a plurality of hooks that depend from the rod, with respective components including slots to permit the hooks to engage the rod continuously while sliding.
摘要:
A drill and drive apparatus includes a tube assembly which defines a tool chamber, the tube assembly including a shank adapted to be received within a chuck of a drill. The apparatus further includes a tool holder which is configured to be at least partially received in the tool chamber of the tube assembly, the tool holder having (i) a first tool locking mechanism at a first end portion thereof, and (ii) a second tool locking mechanism at a second end portion thereof. The drill and drive apparatus further includes a tube locking mechanism which is configured to releasably lock the tool holder to the tube assembly when the tool holder is at least partially received in the tool chamber. The shank defines (i) a first shank opening, (ii) a second shank opening, and (iii) a bit passage extending from the first shank opening to the second shank opening, whereby a drill bit locked to the tool holder by the first tool locking mechanism may extend through the first shank opening, the bit passage, and the second shank opening when the tool holder is locked to the tube assembly.
摘要:
A tool having a body with two broad sides and a margin along which a cutting edge extends, and discrete, discontinuous protrusions from at least one of said broad sides, spaced from said cutting edge and from one another. The protrusions can take the form of concave dimples with a ridge on their perimeter or convex dimples with a smooth outermost surface, with or without complementary concave dimples, which preferably, but not necessarily, have ridges on their perimeters.
摘要:
A valet rod slide mounting assembly is provided for mounting to a supporting surface, such as a door, closet organizer, wall, or the like. The assembly includes a rod and a tube receiving the rod for sliding movement between an extended position and a retracted position when the tube overlaps substantially the rod. The assembly also includes at least two anchors for mounting the tube to the supporting surface. The anchors include a first bore sized to receive the tube and a second bore perpendicular to the first bore and sized to receive a mounting element that engages the support surface. The anchors can also include a third bore where a tube retainer is positioned to engage the tube securably. The assembly can also include a plurality of hooks that depend from the rod, with respective components including slots to permit the hooks to engage the rod continuously while sliding.
摘要:
A cabinet slide assembly permits the soft-close action and/or a soft-open action of a drawer. The cabinet slide assembly includes a cabinet, a drawer, and at least one slide mechanism coupling the drawer to the cabinet to permit movement of the drawer between a fully open position and a fully closed position. A gas spring is also included in the assembly having a first end coupled to a portion of the cabinet assembly and a second end coupled to a portion of the drawer assembly. The gas spring is permitted to swing through an arc along a vertical plane as the drawer moves between the fully open position and the fully closed position. An adjustable bracket can also be included in the assembly and is configured for a top mount drawer assembly having a concealed drawer slide mechanism. The bracket is also configured for face frame or frameless cabinet construction.
摘要:
A saw blade includes a blade body which defines a first side surface and a second side surface, wherein (i) the blade body has a multiplicity of discrete dimples formed on at least one of the side surfaces, (ii) the blade body is made of metal, and (iii) each of the multiplicity of dimples is formed by a process which includes the step of deforming the metal so as to create an indentation in the side surface in which the dimple is formed. The saw blade further includes a plurality of cutting teeth extending from an edge of the blade body. Moreover, the deforming step includes the step of deforming the metal with pins on a die plate of a punch press.
摘要:
A soft-close cabinet slide assembly permits the soft-close action and/or a soft-open action of a drawer, and thus the reduction of effort by an operator, when the drawer is opening or closing. The cabinet slide assembly includes a cabinet, a drawer, and at least one slide mechanism coupling the drawer to the cabinet to permit movement of the drawer between a fully open position and a fully closed position. A forcing means for exerting an extension force, preferably a gas spring, is also be included in the soft-close cabinet slide assembly having a first end coupled to the cabinet and a second end coupled to the drawer. Preferably, the soft-close cabinet slide assembly also includes a first and second pivotal coupling, which permit the gas spring to swing through an arc as the drawer moves between the fully open position and the fully closed position.
摘要:
A cabinet slide assembly permits the soft-close action and/or a soft-open action of a drawer. The cabinet slide assembly includes a cabinet, a drawer, and at least one slide mechanism coupling the drawer to the cabinet to permit movement of the drawer between a fully open position and a fully closed position. A gas spring is also included in the assembly having a first end coupled to a portion of the cabinet assembly and a second end coupled to a portion of the drawer assembly. The gas spring is permitted to swing through an arc along a vertical plane as the drawer moves between the fully open position and the fully closed position. An adjustable bracket can also be included in the assembly and is configured for a top mount drawer assembly having a concealed drawer slide mechanism. The bracket is also configured for face frame or frameless cabinet construction.