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1.3,4-di-substituted maleimide compounds as CXC chemokine receptor antagonists 失效
标题翻译: 3,4-二取代的马来酰亚胺化合物作为CXC趋化因子受体拮抗剂公开(公告)号:US06903131B2
公开(公告)日:2005-06-07
申请号:US10269775
申请日:2002-10-11
申请人: Arthur G. Taveras , Michael Dwyer , Johan A. Ferreira , Viyyoor M. Girijavallabhan , Jianping Chao , John J. Baldwin , J. Robert Merritt , Ge Li
发明人: Arthur G. Taveras , Michael Dwyer , Johan A. Ferreira , Viyyoor M. Girijavallabhan , Jianping Chao , John J. Baldwin , J. Robert Merritt , Ge Li
IPC分类号: A61K31/337 , A61K31/4015 , A61K31/402 , A61K31/4025 , A61K31/4155 , A61K31/4192 , A61K31/4439 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/5377 , A61K31/56 , A61K38/00 , A61K38/21 , A61K38/22 , A61K38/55 , A61K39/395 , A61K45/00 , A61P1/02 , A61P1/04 , A61P1/16 , A61P1/18 , A61P3/10 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/12 , A61P11/00 , A61P11/06 , A61P11/08 , A61P11/10 , A61P13/12 , A61P17/02 , A61P17/06 , A61P19/02 , A61P19/06 , A61P19/10 , A61P21/00 , A61P25/00 , A61P25/28 , A61P27/02 , A61P31/04 , A61P31/18 , A61P31/20 , A61P31/22 , A61P35/00 , A61P37/06 , A61P37/08 , A61P43/00 , C07D207/44 , C07D207/456 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
CPC分类号: C07D207/456 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
摘要: Disclosed are compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译: 公开了式(I)化合物或其药学上可接受的盐或溶剂化物。 该化合物可用于治疗趋化因子介导的疾病,例如急性和慢性炎症性疾病和癌症。
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2.3,4-DI-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands 有权
标题翻译: 3,4-DI取代的环丁烯-1,2-二酮作为CXC-趋化因子受体配体公开(公告)号:US07964646B2
公开(公告)日:2011-06-21
申请号:US11500739
申请日:2006-08-08
申请人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz , Gaifa Lai
发明人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz , Gaifa Lai
IPC分类号: C07C233/00 , A01N37/18
CPC分类号: C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译: 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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3.3,4-Di-Substituted Cyclobutene-1,2-Diones as CXC-Chemokine Receptor Ligands 审中-公开
标题翻译: 3,4-二取代的环丁烯-1,2-二酮作为CXC趋化因子受体配体公开(公告)号:US20110213029A1
公开(公告)日:2011-09-01
申请号:US13102554
申请日:2011-05-06
申请人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
发明人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
IPC分类号: A61K31/341 , A61P11/00
CPC分类号: C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译: 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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4.3,4-DI-SUBSTITUTED CYCLOBUTENE-1,2-DIONES AS CXC-CHEMOKINE RECEPTOR LIGANDS 有权
标题翻译: 作为CXC-CHEMOKINE受体配体的3,4-二取代的环己基-1,2-二酮公开(公告)号:US20090306079A1
公开(公告)日:2009-12-10
申请号:US12352781
申请日:2009-01-13
申请人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
发明人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, JR. , Laura L. Rokosz , Gaifa Lai , James P. Jakway , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
IPC分类号: A61K31/535 , C07D401/04 , C07D295/14 , A61P37/02 , A61P9/12 , A61K31/497
CPC分类号: C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译: 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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5.3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands 有权
标题翻译: 3,4-二取代的环丁烯-1,2-二酮作为CXC-趋化因子受体配体公开(公告)号:US07132445B2
公开(公告)日:2006-11-07
申请号:US10630258
申请日:2003-07-30
申请人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz , James P. Jakway , Gaifa Lai , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
发明人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz , James P. Jakway , Gaifa Lai , Minglang Wu , Evan A. Hecker , Daniel Lundell , Jay S. Fine
IPC分类号: A61K31/341 , A61K31/343 , A61K31/381 , C07D333/10 , C07D33/72
CPC分类号: C07D207/335 , C07C225/20 , C07C237/30 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译: 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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6.3,4-di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands 有权
标题翻译: 3,4-二取代的环丁烯-1,2-二酮作为CXC-趋化因子受体配体公开(公告)号:US07947720B2
公开(公告)日:2011-05-24
申请号:US12352781
申请日:2009-01-13
申请人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz
发明人: Arthur G. Taveras , Cynthia J. Aki , Richard W. Bond , Jianping Chao , Michael Dwyer , Johan A. Ferreira , Jianhua Chao , Younong Yu , John J. Baldwin , Bernd Kaiser , Ge Li , J. Robert Merritt , Purakkattle J. Biju , Kingsley H. Nelson, Jr. , Laura L. Rokosz
IPC分类号: C07D261/04 , C07D327/04 , A01N43/80 , A01N43/06
CPC分类号: C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译: 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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7.3,4-di-substituted pyridazinediones as CXC chemokine receptor antagonists 失效
标题翻译: 3,4-二取代的哒嗪二酮作为CXC趋化因子受体拮抗剂公开(公告)号:US06878709B2
公开(公告)日:2005-04-12
申请号:US10335789
申请日:2003-01-02
申请人: Arthur G. Taveras , Michael Dwyer , Jianping Chao , John J. Baldwin , J. Robert Merritt , Ge Li , Jianhua Chao , Younong Yu
发明人: Arthur G. Taveras , Michael Dwyer , Jianping Chao , John J. Baldwin , J. Robert Merritt , Ge Li , Jianhua Chao , Younong Yu
IPC分类号: A61K31/50 , A61K31/501 , A61K31/506 , A61K31/5377 , A61K45/00 , A61P1/02 , A61P1/04 , A61P7/02 , A61P9/00 , A61P9/10 , A61P9/14 , A61P11/00 , A61P11/06 , A61P13/12 , A61P17/00 , A61P17/06 , A61P19/02 , A61P25/28 , A61P27/02 , A61P31/04 , A61P31/12 , A61P31/14 , A61P31/18 , A61P31/20 , A61P31/22 , A61P33/06 , A61P35/00 , A61P37/02 , A61P37/04 , A61P39/00 , A61P43/00 , C07D237/22 , C07D401/12 , C07D403/12 , C07D405/12 , C07D409/12 , C07D409/14 , C07D417/12
CPC分类号: C07D403/12 , C07D237/22 , C07D405/12 , C07D409/12 , C07D417/12
摘要: Disclosed are compounds of the formula (I) or a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译: 公开了式(I)化合物或其药学上可接受的盐或溶剂化物。 该化合物可用于治疗趋化因子介导的疾病,例如急性和慢性炎症性疾病和癌症。
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8.3,4-Di-substituted cyclobutene-1,2-diones as CXC-chemokine receptor ligands 有权
标题翻译: 3,4-二取代的环丁烯-1,2-二酮作为CXC-趋化因子受体配体公开(公告)号:US20070021494A1
公开(公告)日:2007-01-25
申请号:US11500739
申请日:2006-08-08
申请人: Arthur Taveras , Cynthia Aki , Richard Bond , Jianping Chao , Michael Dwyer , Johan Ferreira , Jianhua Chao , Younong Yu , John Baldwin , Bernd Kaiser , Ge Li , J. Merritt , Purakkattle Biju , Kingsley Nelson , Laura Rokosz , Gaifa Lai , James Jakway , Minglang Wu , Evan Hecker , Daniel Lundell , Jay Fine
发明人: Arthur Taveras , Cynthia Aki , Richard Bond , Jianping Chao , Michael Dwyer , Johan Ferreira , Jianhua Chao , Younong Yu , John Baldwin , Bernd Kaiser , Ge Li , J. Merritt , Purakkattle Biju , Kingsley Nelson , Laura Rokosz , Gaifa Lai , James Jakway , Minglang Wu , Evan Hecker , Daniel Lundell , Jay Fine
IPC分类号: A61K31/4709 , A61K31/4436 , A61K31/427 , A61K31/422 , A61K31/4178 , A61K31/381 , C07D409/02 , C07D413/02 , C07D417/02
CPC分类号: C07C237/30 , C07C225/20 , C07C237/36 , C07C237/44 , C07C255/59 , C07C311/39 , C07C2601/04 , C07C2601/14 , C07C2602/08 , C07D207/335 , C07D213/74 , C07D217/24 , C07D295/26 , C07D307/38 , C07D307/52 , C07D307/68 , C07D307/81 , C07D307/82 , C07D307/83 , C07D317/46 , C07D319/18 , C07D333/20 , C07D333/36 , C07D405/12 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14
摘要: There are disclosed compounds of the formula or a pharmaceutically acceptable salt or solvate thereof which are useful for the treatment of chemokine-mediated diseases such as acute and chronic inflammatory disorders and cancer.
摘要翻译: 公开了可用于治疗趋化因子介导的疾病如急性和慢性炎症性疾病和癌症的下式的化合物或其药学上可接受的盐或溶剂合物。
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9.
公开(公告)号:US20070281951A1
公开(公告)日:2007-12-06
申请号:US11788856
申请日:2007-04-20
申请人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Marc Labroli , Kartik Keertikar
发明人: Timothy Guzi , Kamil Paruch , Michael Dwyer , Marc Labroli , Kartik Keertikar
IPC分类号: A61K31/495
CPC分类号: A61K31/519 , A61K45/06 , A61K2300/00
摘要: In its many embodiments, the present invention provides a novel class of pyrazolo[1,5-a]pyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or compositions.
摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的吡唑并[1,5-a]嘧啶化合物作为细胞周期蛋白依赖性激酶的抑制剂,制备此类化合物的方法,含有一种或多种此类化合物的组合物,制备药物制剂的方法,包括 一种或多种这样的化合物,以及使用这些化合物或组合物治疗,预防,抑制或改善与CDK相关的一种或多种疾病的方法。
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10.
公开(公告)号:US20070094023A1
公开(公告)日:2007-04-26
申请号:US11331374
申请日:2006-01-12
申请人: Jeffrey Gallino , Michael Dwyer , Sean Hart , David Goedecke , Peter Slade
发明人: Jeffrey Gallino , Michael Dwyer , Sean Hart , David Goedecke , Peter Slade
IPC分类号: G10L15/04
摘要: Methods and apparatus are provided which may be employed to perform speech recognition processing on a grid computing system. In some embodiments, the grid computing system includes a server system which receives processing tasks from one or more client applications, divides the processing tasks into units of work, and assigns the units of work to one or more of the nodes. Dividing a processing task into units of work may involve dividing audio input data into segments defined by natural speech boundaries. A mathematical representation may be created for each segment prior to its distribution on the grid to minimize network traffic. A node in the system may perform heterogeneous units of work concurrently, such as by isolating the execution of each unit of work in an application domain.
摘要翻译: 提供了可以用于对网格计算系统执行语音识别处理的方法和装置。 在一些实施例中,网格计算系统包括从一个或多个客户端应用接收处理任务的服务器系统,将处理任务划分为工作单元,并将工作单元分配给一个或多个节点。 将处理任务划分为工作单元可能包括将音频输入数据划分为由自然语音边界定义的段。 可以在网格上分配之前为每个段创建一个数学表示,以最大限度地减少网络流量。 系统中的节点可以同时执行异构工作单元,例如通过隔离应用程序域中每个工作单元的执行。
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