公开(公告)号：US4256732A

公开(公告)日：1981-03-17

申请号：US78813

申请日：1979-09-25

申请人： Arthur Malley

发明人： Arthur Malley

IPC分类号： A61K39/36

CPC分类号： A61K39/36

摘要： Oxidative rearrangement and cleavage of hydroxy aromatic rings of quercitin moiety of Timothy grass pollen antigen or antigenic fragments gives rise to a modified antigen having no antigenic properties but retaining capability of activating T-cells for regulation of immune response.The invention includes the modified antigens, the method of oxidative cleavage, immunotherapeutic methods for alleviating allergic responses to the Timothy grass pollen antigens and immunotherapeutic compositions therefor.

摘要翻译： Timothy草花粉抗原或抗原片段的槲皮素部分的羟基芳环的氧化重排和切割产生不具有抗原性质但保留活化T细胞以调节免疫应答的能力的修饰抗原。 本发明包括修饰的抗原，氧化切割的方法，用于减轻针对蒂莫西草花粉抗原的过敏反应的免疫治疗方法及其免疫治疗组合物。

公开(公告)号：US4215036A

公开(公告)日：1980-07-29

申请号：US933907

申请日：1978-08-15

申请人： Arthur Malley

发明人： Arthur Malley

IPC分类号： A61K39/36 ,  C08H1/00

CPC分类号： A61K39/36 ,  Y10S530/806

摘要： Oxidative rearrangement and cleavage of hydroxy aromatic rings of quercitin moiety of Timothy grass pollen antigen or antigen fragments gives rise to a modified antigen having no antigenic properties but retaining capability of activating T-cells for regulation of immune response.The invention includes the modified antigens, the method of oxidative cleavage, immunotherapeutic methods for alleviating allergic responses to the Timothy grass pollen antigens and immunotherapeutic compositions therefor.

摘要翻译： Timothy草花粉抗原或抗原片段的槲皮素部分的羟基芳环的氧化重排和切割产生不具有抗原性质但保留活化T细胞以调节免疫应答的能力的经修饰的抗原。 本发明包括修饰的抗原，氧化切割的方法，用于减轻针对蒂莫西草花粉抗原的过敏反应的免疫治疗方法及其免疫治疗组合物。

公开(公告)号：US4158705A

公开(公告)日：1979-06-19

申请号：US922222

申请日：1978-07-05

申请人： Arthur Malley

发明人： Arthur Malley

IPC分类号： A61K31/70 ,  A61K38/095 ,  A61K39/35 ,  A61K39/36 ,  A61P37/00 ,  A61P37/08 ,  C07D311/30 ,  C07H17/07

CPC分类号： A61K39/36 ,  C07D311/30 ,  C07H17/07 ,  A61K2039/6093 ,  A61K2039/627 ,  A61K38/00 ,  Y10S424/805 ,  Y10S530/806 ,  Y10S530/868

摘要： A multivalent complex suitable for blocking allergic reactions comprising (1) at least one Timothy antigen D fragment having the antigenic determinant structure: ##STR1## wherein: G represents glucose, andT represents threonine or a peptide linked to said structure through a threonine molecule;Covalently bonded through at least one glucose moiety to a peptide or protein, (2) a conjugate having the structure: ##STR2## OR (3) A CONJUGATE COMPRISING AT LEAST ONE CONJUGATE OF THE STRUCTURE: ##STR3## CONVALENTLY BONDED TO A PROTEIN OR PEPTIDE BY A PEPTIDE LINKAGE THROUGH THE GLUTATHIONE MOIETY.A method of forming complex (1) by activating a glucose moiety of the Timothy antigen D fragment and reacting the thus activated intermediate with a peptide or protein.A method of treating allergies comprising injecting one of the above complexes into an individual to inhibit antigen-induced histamine release.An injectable composition for blocking allergic reactions containing the above complex.

公开(公告)号：US4545986A

公开(公告)日：1985-10-08

申请号：US390923

申请日：1982-06-22

申请人： Arthur Malley

发明人： Arthur Malley

IPC分类号： A61K38/00 ,  A61K39/00 ,  C07K16/24 ,  C07K16/42 ,  A61K39/395 ,  A61K37/02 ,  A61K39/36 ,  C12N5/00 ,  C12N5/02

CPC分类号： C07K16/4208 ,  C07K16/24 ,  A61K38/00 ,  A61K39/00 ,  C07K2317/74 ,  Y10S424/805 ,  Y10S424/81 ,  Y10S530/806 ,  Y10S530/829 ,  Y10S530/83 ,  Y10S530/838 ,  Y10S530/868

摘要： This invention provides a number of immunological reagents useful for the suppression of allergic reactions induced by Timothy-grass pollen allergen (or cross-reacting allergens thereof) and for methods of obtaining said reagents. The reagents include: (1) an anti-idiotypic antibody (anti-IgE.sub.id) directed to the allergen (Timothy grass antigen) binding site of an IgE immunoglobulin; (2) an anti-idiotypic antibody directed to the allergenic T-cell helper factor (T.sub.HF) derived from Timothy grass pollen antigen stimulated lymphocytes; (3) unique methods for generating antigen-specific T-suppressor cells (T.sub.S); (4) a unique method for producing antigen-specific suppressor T cell factors (T.sub.SF); (5) a method for fractionation of T.sub.SF ; and (6) a specific T cell factor, T.sub.SF2. The invention further provides pharmaceutical compositions comprising the above anti-idiotypic antibodies or suppressor factor derived from T.sub.s cells.

摘要翻译： 本发明提供了许多用于抑制由蒂莫西草花粉变应原（或其交叉反应变应原）诱导的过敏反应的免疫试剂以及获得所述试剂的方法。 试剂包括：（1）针对IgE免疫球蛋白的变应原（提莫西草抗原）结合位点的抗独特型抗体（抗IgEid）; （2）针对来自提摩诃草花粉抗原刺激的淋巴细胞的变应原性T细胞辅助因子（THF）的抗独特型抗体; （3）产生抗原特异性T抑制细胞（TS）的独特方法; （4）抗原特异性抑制T细胞因子（TSF）的独特方法; （5）分离TSF的方法; 和（6）特异性T细胞因子TSF2。 本发明还提供包含上述抗独特型抗体或衍生自Ts细胞的抑制因子的药物组合物。

公开(公告)号：US4140679A

公开(公告)日：1979-02-20

申请号：US731414

申请日：1976-10-12

申请人： Arthur Malley

发明人： Arthur Malley

IPC分类号： A61K31/70 ,  A61K38/095 ,  A61K39/35 ,  A61K39/36 ,  A61P37/00 ,  A61P37/08 ,  C07D311/30 ,  C07H17/07 ,  C08G69/36

CPC分类号： A61K39/36 ,  C07D311/30 ,  C07H17/07 ,  A61K2039/6093 ,  A61K2039/627 ,  A61K38/00 ,  Y10S424/805 ,  Y10S530/806 ,  Y10S530/868

摘要： A multivalent complex suitable for blocking allergic reactions comprising (1) at least one Timothy antigen D fragment having the antigenic determinant structure: ##STR1## wherein: G represents glucose, andT represents threonine or a peptide linked to said structure through a threonine molecule;Covalently bonded through at least one glucose moiety to a peptide or protein, (2) a conjugate having the structure: ##STR2## OR (3) A CONJUGATE COMPRISING AT LEAST ONE CONJUGATE OF THE STRUCTURE: ##STR3## COVALENTLY BONDED TO A PROTEIN OR PEPTIDE BY A PEPTIDE LINKAGE THROUGH THE GLUTATHIONE MOIETY.A method of forming complex (1) by activating a glucose moiety of the Timothy antigen D fragment and reacting the thus activated intermediate with a peptide or protein.A method of treating allergies comprising injecting one of the above complexes into an individual to inhibit antigen-induced histamine release.An injectable composition for blocking allergic reactions containing the above complex.

摘要翻译： 适用于阻断过敏反应的多价复合物，其包含（1）至少一种具有抗原决定簇结构的Timothy抗原D片段：其中：