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公开(公告)号:US20110207216A1
公开(公告)日:2011-08-25
申请号:US13028635
申请日:2011-02-16
申请人: Arthur Winston Martin , Kevin Robert McCarthy , Shawn Michael O'Malley , Simon Kelly Shannon , Meenal Pauddar Soni
发明人: Arthur Winston Martin , Kevin Robert McCarthy , Shawn Michael O'Malley , Simon Kelly Shannon , Meenal Pauddar Soni
IPC分类号: C12N5/0775
CPC分类号: C12N5/0075 , C12N5/0663 , C12N2501/58 , C12N2533/20 , C12N2533/30
摘要: A process for forming microcarriers includes contacting an initiator-conjugated microcarrier base with one or more monomers and activating the initiator to initiate polymerization and to graft a polymer from the base via the initiator or a remnant thereof. At least one of the monomers is conjugated to a polypeptide so that incorporation of the monomer into the forming polymer conjugates the polypeptide to the polymeric coating as it is formed in situ.
摘要翻译: 形成微载体的方法包括使引发剂共轭的微载体碱与一种或多种单体接触并活化引发剂以引发聚合并通过引发剂或其残余物从基底接枝聚合物。 至少一种单体与多肽缀合,使得单体在成形聚合物中的并入将其形成于原位形成聚合物涂层。
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公开(公告)号:US20120208266A1
公开(公告)日:2012-08-16
申请号:US13367661
申请日:2012-02-07
申请人: Dana Craig Bookbinder , Arthur Winston Martin , Jodelle Karen Nelson , Shawn Michael O'Malley , Meenal Pauddar Soni
发明人: Dana Craig Bookbinder , Arthur Winston Martin , Jodelle Karen Nelson , Shawn Michael O'Malley , Meenal Pauddar Soni
IPC分类号: C12M3/00
CPC分类号: C12N5/0068 , C12M25/00 , C12M25/06 , C12N2533/30 , C12N2533/50 , C12N2539/10
摘要: Disclosed herein are cell culture surfaces comprising a substrate and a polymer layer on the substrate where the polymer layer contains enzyme-cleavable amino acid sequences and cell adhesive peptide sequences.
摘要翻译: 本文公开了包含基底和基底上的聚合物层的细胞培养物表面,其中聚合物层含有可酶切的氨基酸序列和细胞粘附肽序列。
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