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公开(公告)号：US20110207216A1
公开(公告)日：2011-08-25
申请号：US13028635
申请日：2011-02-16
申请人： Arthur Winston Martin , Kevin Robert McCarthy , Shawn Michael O'Malley , Simon Kelly Shannon , Meenal Pauddar Soni
发明人： Arthur Winston Martin , Kevin Robert McCarthy , Shawn Michael O'Malley , Simon Kelly Shannon , Meenal Pauddar Soni
IPC分类号： C12N5/0775
CPC分类号： C12N5/0075 , C12N5/0663 , C12N2501/58 , C12N2533/20 , C12N2533/30
摘要： A process for forming microcarriers includes contacting an initiator-conjugated microcarrier base with one or more monomers and activating the initiator to initiate polymerization and to graft a polymer from the base via the initiator or a remnant thereof. At least one of the monomers is conjugated to a polypeptide so that incorporation of the monomer into the forming polymer conjugates the polypeptide to the polymeric coating as it is formed in situ.
摘要翻译： 形成微载体的方法包括使引发剂共轭的微载体碱与一种或多种单体接触并活化引发剂以引发聚合并通过引发剂或其残余物从基底接枝聚合物。 至少一种单体与多肽缀合，使得单体在成形聚合物中的并入将其形成于原位形成聚合物涂层。
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公开(公告)号：US20120208266A1
公开(公告)日：2012-08-16
申请号：US13367661
申请日：2012-02-07
申请人： Dana Craig Bookbinder , Arthur Winston Martin , Jodelle Karen Nelson , Shawn Michael O'Malley , Meenal Pauddar Soni
发明人： Dana Craig Bookbinder , Arthur Winston Martin , Jodelle Karen Nelson , Shawn Michael O'Malley , Meenal Pauddar Soni
IPC分类号： C12M3/00
CPC分类号： C12N5/0068 , C12M25/00 , C12M25/06 , C12N2533/30 , C12N2533/50 , C12N2539/10
摘要： Disclosed herein are cell culture surfaces comprising a substrate and a polymer layer on the substrate where the polymer layer contains enzyme-cleavable amino acid sequences and cell adhesive peptide sequences.
摘要翻译： 本文公开了包含基底和基底上的聚合物层的细胞培养物表面，其中聚合物层含有可酶切的氨基酸序列和细胞粘附肽序列。
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公开(公告)号：US20120208972A1
公开(公告)日：2012-08-16
申请号：US13369689
申请日：2012-02-09
申请人： Dana Craig Bookbinder , Paul Ernest Gagnon, JR. , Arthur Winston Martin , Jodelle Karen Nelson , Shawn Michael O'Malley
发明人： Dana Craig Bookbinder , Paul Ernest Gagnon, JR. , Arthur Winston Martin , Jodelle Karen Nelson , Shawn Michael O'Malley
IPC分类号： C08F222/38
CPC分类号： C08F222/38 , C08F220/58 , C08F220/70 , C08G69/10
摘要： Disclosed herein are functionalized cationic peptide monomers: peptide chains of two or more positively charged amino acids chosen from lysine or arginine, or derivatives thereof, which are functionalized, meaning that they are bound to one or more polymerization moieties. The functionalized cationic peptide monomers can be described by the formula Z-Xaan-Z1n1 wherein Z and Z1 are polymerization moieties and n1 is an integer of 0 or 1; Xaa is each independently an amino acid Lys or Arg and n is an integer from 2 to 10 and wherein at least one Xaa amino acid of Xaa is Lys, wherein the carboxyl terminus of the amino acid sequence is amidated. Functionalized cationic peptide monomers can be combined and polymerized to form cell culture surfaces.
摘要翻译： 本文公开了官能化的阳离子肽单体：选自赖氨酸或精氨酸或其衍生物的两个或更多个带正电荷的氨基酸的肽链，其被官能化，意味着它们与一个或多个聚合部分结合。 官能化阳离子肽单体可以用式Z-Xanan-Z1n1描述，其中Z和Z 1是聚合部分，n 1是0或1的整数; Xaa各自独立地是氨基酸Lys或Arg，n是2至10的整数，并且其中Xaa的至少一个Xaa氨基酸是Lys，其中氨基酸序列的羧基末端被酰胺化。 官能化阳离子肽单体可以组合并聚合以形成细胞培养物表面。
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公开(公告)号：US08981025B2
公开(公告)日：2015-03-17
申请号：US13369689
申请日：2012-02-09
申请人： Dana Craig Bookbinder , Paul Ernest Gagnon, Jr. , Arthur Winston Martin , Jodelle Karen Nelson , Shawn Michael O'Malley
发明人： Dana Craig Bookbinder , Paul Ernest Gagnon, Jr. , Arthur Winston Martin , Jodelle Karen Nelson , Shawn Michael O'Malley
IPC分类号： C08F222/38 , C08G69/10 , C08F220/70 , C08F220/58
CPC分类号： C08F222/38 , C08F220/58 , C08F220/70 , C08G69/10
摘要： Disclosed herein are functionalized cationic peptide monomers: peptide chains of two or more positively charged amino acids chosen from lysine or arginine, or derivatives thereof, which are functionalized, meaning that they are bound to one or more polymerization moieties. The functionalized cationic peptide monomers can be described by the formula Z-Xaan-Z1n1 wherein Z and Z1 are polymerization moieties and n1 is an integer of 0 or 1; Xaa is each independently an amino acid Lys or Arg and n is an integer from 2 to 10 and wherein at least one Xaa amino acid of Xaa is Lys, wherein the carboxyl terminus of the amino acid sequence is amidated. Functionalized cationic peptide monomers can be combined and polymerized to form cell culture surfaces.
摘要翻译： 本文公开了官能化的阳离子肽单体：选自赖氨酸或精氨酸或其衍生物的两个或更多个带正电荷的氨基酸的肽链，其被官能化，意味着它们与一个或多个聚合部分结合。 官能化阳离子肽单体可以用式Z-Xanan-Z1n1描述，其中Z和Z 1是聚合部分，n 1是0或1的整数; Xaa各自独立地是氨基酸Lys或Arg，n是2至10的整数，并且其中Xaa的至少一个Xaa氨基酸是Lys，其中氨基酸序列的羧基末端被酰胺化。 官能化阳离子肽单体可以组合并聚合以形成细胞培养物表面。
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公开(公告)号：US20120220720A1
公开(公告)日：2012-08-30
申请号：US13121825
申请日：2010-07-29
申请人： Dana Craig Bookbinder , Arthur Winston Martin , Jodelle Karen Nelson , Shawn Michael O'Malley , Yue Zhou
发明人： Dana Craig Bookbinder , Arthur Winston Martin , Jodelle Karen Nelson , Shawn Michael O'Malley , Yue Zhou
CPC分类号： C07K14/70503 , C12N5/0068 , C12N5/0606 , C12N2533/30 , C12N2533/50
摘要： Synthetic surfaces capable of supporting culture of cells in culture, particularly cells that will be used therapeutically, are disclosed. The synthetic cell culture surfaces have a functionalized peptide, a peptide that has been functionalized to contain a polymerization moiety, and optionally a spacer, grafted to a hydrophilic polymeric base material. Methods of making the surfaces and methods of using the surfaces are also disclosed.
摘要翻译： 公开了能够支持培养细胞培养的合成表面，特别是治疗性细胞的细胞。 合成细胞培养物表面具有官能化肽，已被官能化以含有聚合部分的肽，以及任选的间接物，接枝到亲水性聚合物基材上。 还公开了制造表面的方法和使用表面的方法。
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6.发明申请DIMENSIONAL SILICA-BASED POROUS SILICON STRUCTURES AND METHODS OF FABRICATION 审中-公开尺寸二氧化硅多孔硅结构和制造方法公开(公告)号：US20130209781A1
公开(公告)日：2013-08-15
申请号：US13847740
申请日：2013-03-20
申请人： Robert Alan Bellman , Nicholas Francis Borrelli , David Alan Deneka , Shawn Michael O'Malley , Vitor Marino Schneider
发明人： Robert Alan Bellman , Nicholas Francis Borrelli , David Alan Deneka , Shawn Michael O'Malley , Vitor Marino Schneider
IPC分类号： C03C23/00 , H01L21/322
CPC分类号： C03C23/0095 , C03C23/008 , H01L21/02002 , H01L21/02422 , H01L21/0245 , H01L21/02513 , H01L21/02532 , H01L21/02658 , H01L21/2257 , H01L21/3221 , H01L29/78603 , Y10T428/249969
摘要： Methods of fabricating dimensional silica-based substrates or structures comprising a porous silicon layers are contemplated. According to one embodiment, oxygen is extracted from the atomic elemental composition of a silica glass substrate by reacting a metallic gas with the substrate in a heated inert atmosphere to form a metal-oxygen complex along a surface of the substrate. The metal-oxygen complex is removed from the surface of the silica glass substrate to yield a crystalline porous silicon surface portion and one or more additional layers are formed over the crystalline porous silicon surface portion of the silica glass substrate to yield a dimensional silica-based substrate or structure comprising the porous silicon layer. Embodiments are also contemplated where the substrate is glass-based, but is not necessarily a silica-based glass substrate. Additional embodiments are disclosed and claimed.
摘要翻译： 考虑制造尺寸二氧化硅基底或包括多孔硅层的结构的方法。 根据一个实施方案，通过在加热的惰性气氛中使金属气体与衬底反应，从石英玻璃衬底的原子元素组合物中提取氧，以沿着衬底的表面形成金属 - 氧络合物。 从石英玻璃基板的表面除去金属 - 氧络合物，得到结晶多孔硅表面部分，并且在石英玻璃基板的结晶多孔硅表面部分上形成一个或多个附加层，得到尺寸二氧化硅基 包括多孔硅层的衬底或结构。 也可以考虑实施方案，其中基材是玻璃基的，但不一定是二氧化硅基玻璃基材。 公开并要求保护附加实施例。
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公开(公告)号：US20130149549A1
公开(公告)日：2013-06-13
申请号：US13693453
申请日：2012-12-04
IPC分类号： C01B33/023 , C01B33/02
CPC分类号： C01B33/023 , B22F1/0011 , B22F1/0025 , B22F1/0048 , B22F9/30 , B22F2304/054 , B22F2304/056 , B22F2304/058 , B22F2304/10 , B22F2998/10 , B82Y40/00 , C01B33/02 , Y10S977/762 , Y10S977/896 , Y10T428/12479 , B22F1/0088
摘要： Compositions made by metallothermal reduction from aerogels and phase separated glasses and glass ceramics formed and methods of producing such compositions are provided. The compositions have novel structures that incorporate nanoporous silicon and other metal, metalloid, or metal-oxide nanowires in form of three-dimensional scaffolds. Additional compositions possess unusual photoluminescence properties that indicate possible applications in lighting and electronics.
摘要翻译： 提供了由气凝胶和相分离的玻璃和玻璃陶瓷的金属热还原制成的组合物和制备这种组合物的方法。 该组合物具有以三维支架形式纳入纳米多孔硅和其它金属，准金属或金属氧化物纳米线的新结构。 额外的组合物具有不寻常的光致发光性质，表明在照明和电子学中可能的应用。
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公开(公告)号：US20130220211A1
公开(公告)日：2013-08-29
申请号：US13765800
申请日：2013-02-13
IPC分类号： C30B1/04
CPC分类号： C30B1/04 , C01B33/02 , C01B33/023
摘要： Compositions made by metallothermal reduction from crystalline materials and methods of producing such compositions are provided. The compositions have novel crystalline structures in the form of three-dimensional scaffolds. Additionally, the compositions possess unusual properties that indicate possible applications in numerous applications.
摘要翻译： 提供了通过结晶材料的金属热还原制备的组合物和制备这种组合物的方法。 组合物具有三维支架形式的新颖晶体结构。 此外，组合物具有不寻常的性质，其指示在许多应用中的可能应用。
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公开(公告)号：US20130133739A1
公开(公告)日：2013-05-30
申请号：US13812976
申请日：2011-08-29
IPC分类号： B05D5/06 , H01L31/0216
CPC分类号： B05D5/061 , C03C17/008 , C03C2217/475 , C03C2218/113 , C23C18/1225 , C23C18/1233 , C23C18/1245 , C23C18/1254 , H01L31/0216 , H01L31/02366 , Y02E10/52
摘要： Light scattering substrates made by providing a substrate comprising at least one surface, forming a layer of particles by depositing a sol-gel on the at least one surface, and heating the coated substrate.
摘要翻译： 通过提供包括至少一个表面的基底制成的光散射基板，通过在所述至少一个表面上沉积溶胶 - 凝胶而形成一层颗粒，并加热涂覆的基底。
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公开(公告)号：US20090059367A1
公开(公告)日：2009-03-05
申请号：US11897899
申请日：2007-08-30
IPC分类号： G02B5/30
CPC分类号： G02B5/3058 , C03C14/002 , C03C2214/08 , G02B5/3075
摘要： A process wherein a polymer, such as DNA, having a defined chemical composition and size is used to template the alignment of polarizing species, such as optically active organic dyes or metal nanoparticles having defined compositional characteristics and/or size and shape characteristics, on a surface to manufacture a thin film polarizer; a process where metal nanorods are aligned on a substrate surface or inside a substrate to make a polarizer; and a polarizer thus made. Multi-layered polarizing structure can be created by using the process of the present invention.
摘要翻译： 使用其中具有确定的化学组成和尺寸的聚合物如DNA的方法来模拟偏光物质的取向，例如具有确定的组成特征和/或尺寸和形状特征的光学活性有机染料或金属纳米颗粒在 表面制造薄膜偏光片; 金属纳米棒在衬底表面上或衬底内对准以制造偏振器的工艺; 和如此制成的偏振片。 可以通过使用本发明的方法产生多层偏振结构。
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