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公开(公告)号:US09382537B2
公开(公告)日:2016-07-05
申请号:US14459182
申请日:2014-08-13
申请人: Asuragen, Inc.
发明人: David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号: C12N15/11 , C12N15/113 , A61K31/7105 , A61K45/06 , A61N5/10 , C12Q1/68 , A61K9/127 , A61K31/7088 , A61K31/713
CPC分类号: C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
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公开(公告)号:US20150004221A1
公开(公告)日:2015-01-01
申请号:US14459182
申请日:2014-08-13
申请人: ASURAGEN, INC.
发明人: David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号: C12N15/113
CPC分类号: C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
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公开(公告)号:US09506061B2
公开(公告)日:2016-11-29
申请号:US14712591
申请日:2015-05-14
申请人: Asuragen, Inc.
发明人: David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号: C12N15/11 , C12N15/113 , A61K31/7105 , A61K45/06 , A61N5/10 , C12Q1/68 , A61K9/127 , A61K31/7088 , A61K31/713
CPC分类号: C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
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公开(公告)号:US09068219B2
公开(公告)日:2015-06-30
申请号:US14459074
申请日:2014-08-13
申请人: Asuragen, Inc.
发明人: David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号: C12N15/11 , C12Q1/68 , C12N15/113 , A61K9/127 , A61K31/7088
CPC分类号: C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
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公开(公告)号:US20140348908A1
公开(公告)日:2014-11-27
申请号:US14459192
申请日:2014-08-13
申请人: ASURAGEN, INC.
发明人: David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号: C12N15/113
CPC分类号: C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
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公开(公告)号:US20140348907A1
公开(公告)日:2014-11-27
申请号:US14459119
申请日:2014-08-13
申请人: ASURAGEN, INC.
发明人: David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号: C12N15/113
CPC分类号: C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
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公开(公告)号:US20140228228A1
公开(公告)日:2014-08-14
申请号:US14062612
申请日:2013-10-24
申请人: ASURAGEN, INC.
发明人: David Brown , Rick Conrad , Eric Devroe , Marianna Goldrick , Kerri Keiger , Emmanuel Labourier , Ivonne Moon , Patricia Powers , Jeffrey Shelton , Jaclyn Shingara
IPC分类号: C12Q1/68
CPC分类号: C12Q1/6806 , C12N15/111 , C12N2310/14 , C12N2310/3517 , C12N2310/3519 , C12N2320/10 , C12P19/34 , C12Q1/6809 , C12Q1/6883 , C12Q2600/158 , C12Q2600/178 , C12Q2565/501 , C12Q2525/207
摘要: The present invention concerns methods and compositions for isolating, enriching, and/or labeling miRNA molecules and for preparing and using arrays or other detection techniques for miRNA analysis. Moreover, the present invention concerns methods and compositions for generating miRNA profiles and employing such profiles for therapeutic, diagnostic, and prognostic applications.
摘要翻译: 本发明涉及用于分离,富集和/或标记miRNA分子以及制备和使用阵列或其他用于miRNA分析的检测技术的方法和组合物。 此外,本发明涉及用于产生miRNA谱并用于治疗,诊断和预后应用的这种分布的方法和组合物。
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公开(公告)号:US20130303591A1
公开(公告)日:2013-11-14
申请号:US13887008
申请日:2013-05-03
申请人: Asuragen, Inc.
发明人: David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitry Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号: C12N15/113
CPC分类号: C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
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公开(公告)号:US09447414B2
公开(公告)日:2016-09-20
申请号:US14741064
申请日:2015-06-16
申请人: Asuragen, Inc.
发明人: David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号: C12N15/11 , C12N15/113 , A61K31/7105 , A61K45/06 , A61N5/10 , C12Q1/68 , A61K9/127 , A61K31/7088 , A61K31/713
CPC分类号: C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
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公开(公告)号:US09051571B2
公开(公告)日:2015-06-09
申请号:US14254532
申请日:2014-04-16
申请人: Asuragen, Inc.
发明人: David Brown , Lance Ford , Angie Cheng , Rich Jarvis , Mike Byrom , Dmitriy Ovcharenko , Eric Devroe , Kevin Kelnar
IPC分类号: C07H21/04 , C12N15/11 , C12N15/113 , C12Q1/68 , A61K9/127 , A61K31/7088
CPC分类号: C12N15/113 , A61K9/127 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K45/06 , A61N5/10 , C12N15/111 , C12N15/1136 , C12N2310/14 , C12N2310/141 , C12N2310/312 , C12N2310/321 , C12N2310/322 , C12N2310/33 , C12N2310/344 , C12N2310/35 , C12N2310/351 , C12N2310/3527 , C12N2310/3535 , C12N2310/533 , C12N2320/12 , C12N2320/30 , C12N2320/50 , C12N2330/10 , C12Q1/68 , C12Q1/6876 , C12Q2600/158 , C12Q2600/178 , C12N2310/3521
摘要: The present invention concerns methods and compositions for introducing miRNA activity or function into cells using synthetic nucleic acid molecules. Moreover, the present invention concerns methods and compositions for identifying miRNAs with specific cellular functions that are relevant to therapeutic, diagnostic, and prognostic applications wherein synthetic miRNAs and/or miRNA inhibitors are used in library screening assays.
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