公开(公告)号：US20180265499A1

公开(公告)日：2018-09-20

申请号：US15921890

申请日：2018-03-15

申请人： Athenex, Inc.

发明人： Michael P. SMOLINSKI ,  Sameer URGAONKAR ,  James Lindsay CLEMENTS ,  David G. HANGAUER, JR.

IPC分类号： C07D403/14 ,  C07D403/12 ,  A61P37/02 ,  A61P37/08

CPC分类号： C07D403/14 ,  A61P37/02 ,  A61P37/08 ,  C07D211/40 ,  C07D403/12

摘要： The present application is directed to biaryl piperidine amide compounds, or pharmaceutically acceptable salts, solvates, and prodrugs thereof, and methods of use thereof.

公开(公告)号：US20180042934A1

公开(公告)日：2018-02-15

申请号：US15676203

申请日：2017-08-14

申请人： Athenex, Inc.

发明人： Michael P. SMOLINSKI ,  Nader N. NASIEF ABDEL-SAYED ,  David G. HANGAUER, JR.

IPC分类号： A61K31/5377 ,  A61K9/00 ,  C07C233/13 ,  C07D213/56 ,  C07D213/74 ,  C07D401/12 ,  C07D403/04 ,  C07C233/22 ,  C07D213/64 ,  A61K31/496 ,  C07D239/34

CPC分类号： A61K31/5377 ,  A61K9/0019 ,  A61K9/0053 ,  A61K9/0085 ,  A61K31/496 ,  C07C233/13 ,  C07C233/22 ,  C07D213/56 ,  C07D213/64 ,  C07D213/74 ,  C07D239/34 ,  C07D401/12 ,  C07D403/04 ,  C07D413/10 ,  C07D413/14

摘要： The application relates to biaryl compounds, pharmaceutical compositions comprising the compounds, and methods of use the compounds for treating cell proliferation disorders.

公开(公告)号：US20200071305A1

公开(公告)日：2020-03-05

申请号：US16567300

申请日：2019-09-11

申请人： Athenex, Inc.

发明人： Michael P. SMOLINSKI ,  Sameer URGAONKAR ,  James Lindsay CLEMENTS ,  David G. HANGAUER, JR.

IPC分类号： C07D403/14 ,  A61P37/02 ,  A61P37/08 ,  C07D403/12

摘要： The present application is directed to biaryl piperidine amide compounds, or pharmaceutically acceptable salts, solvates, and prodrugs thereof, and methods of use thereof.

公开(公告)号：US20190256468A1

公开(公告)日：2019-08-22

申请号：US16398420

申请日：2019-04-30

申请人： Athenex, Inc.

发明人： David G. HANGAUER, JR. ,  Debasis PATRA ,  Jeremy A. CODY ,  Grant J. PALMER ,  Paul K. ISBESTER ,  Jonathon SALSBURY

IPC分类号： C07D213/56 ,  C07D213/59 ,  C07D413/12

摘要： The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl) pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning calorimetry profile, as well as a unique crystalline structure.

公开(公告)号：US20170101378A1

公开(公告)日：2017-04-13

申请号：US15387322

申请日：2016-12-21

申请人： Athenex, Inc.

发明人： David G. HANGAUER, JR. ,  Debasis PATRA ,  Jeremy A. CODY ,  Grant J. PALMER ,  Paul K. ISBESTER ,  Jonathon SALSBURY

IPC分类号： C07D213/56

CPC分类号： C07D213/56 ,  A61K31/44 ,  C07B2200/13 ,  C07D213/59 ,  C07D413/12

摘要： The invention relates to compositions comprising 2-(5-(4-(2-morpholinoethoxy)phenyl) pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts. The invention provides an efficient process for the synthesis of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide and its mesylate and dihydrochloride salts and methods for modulating one or more components of a kinase cascade using the compositions of the invention. The present invention also provides a novel polymorph of the mesylate salt of 2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)-N-benzylacetamide (Form A), characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure.

公开(公告)号：US20210252008A1

公开(公告)日：2021-08-19

申请号：US17151835

申请日：2021-01-19

申请人： Athenex, Inc.

发明人： David G. HANGAUER, JR.

IPC分类号： A61K31/5377 ,  C07C233/13 ,  C07D239/26 ,  C07D239/34 ,  C07D401/12 ,  C07D403/04 ,  C07D213/56 ,  C07D213/89 ,  A61K9/00 ,  A61K31/495

摘要： The invention relates to compounds and methods for modulating one or more components of a kinase cascade.

公开(公告)号：US20190125754A1

公开(公告)日：2019-05-02

申请号：US16232229

申请日：2018-12-26

申请人： Athenex, Inc.

发明人： Michael P. SMOLINSKI ,  Nader N. NASIEF ABDEL-SAYED ,  David G. HANGAUER, JR.

IPC分类号： A61K31/5377 ,  C07C233/22 ,  C07D413/14 ,  C07D401/12 ,  C07D213/56 ,  A61K31/496 ,  C07C233/13 ,  C07D413/10 ,  C07D403/04 ,  C07D213/64 ,  C07D213/74 ,  C07D239/34 ,  A61K9/00

摘要： The application relates to biaryl compounds, pharmaceutical compositions comprising the compounds, and methods of use the compounds for treating cell proliferation disorders.

公开(公告)号：US20180170875A1

公开(公告)日：2018-06-21

申请号：US15895244

申请日：2018-02-13

申请人： Athenex, Inc.

发明人： David G. HANGAUER, JR.

IPC分类号： C07D213/56 ,  C07C303/32 ,  C07C309/29

CPC分类号： C07D213/56 ,  C07C303/32 ,  C07C309/29

摘要： The invention relates to compounds and methods for modulating one or more components of a kinase cascade. The invention also relates to substantially pure compound 1 and substantially pure compound 1 salt (e.g., compound 1 hydrochloride salt and compound 1 benzenesulfonate salt). The invention further relates to methods of preparing substantially pure compound 1 and compound 1 salts.

公开(公告)号：US20170196874A1

公开(公告)日：2017-07-13

申请号：US15408098

申请日：2017-01-17

申请人： Athenex, Inc.

发明人： David G. HANGAUER, JR.

IPC分类号： A61K31/5377 ,  A61K31/495 ,  A61K9/00

CPC分类号： A61K31/5377 ,  A61K9/0053 ,  A61K31/495 ,  C07C233/13 ,  C07C233/22 ,  C07D213/56 ,  C07D213/64 ,  C07D213/74 ,  C07D213/89 ,  C07D239/26 ,  C07D239/34 ,  C07D401/12 ,  C07D403/04

摘要： The invention relates to compounds and methods for modulating one or more components of a kinase cascade.

公开(公告)号：US20220119347A1

公开(公告)日：2022-04-21

申请号：US17462155

申请日：2021-08-31

申请人： Athenex, Inc.

发明人： David G. HANGAUER, JR.

IPC分类号： C07D213/56 ,  C07D213/52 ,  C07D213/89 ,  C07D401/04 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12

摘要： The invention relates to compounds and methods for modulating one or more components of a kinase cascade.