利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

111 条记录 (耗时 0.023 秒)

    Conjugated ketone compounds in preventing platelet thrombosis
    1.
    发明授权
    Conjugated ketone compounds in preventing platelet thrombosis 失效
    共轭酮化合物预防血小板血栓形成

    公开(公告)号：US4418079A

    公开(公告)日：1983-11-29

    申请号：US335522

    申请日：1981-12-29

    申请人： Atsuyuki Kojima ,  Tsunemasa Irie ,  Shuichi Harada ,  Yoshito Kameno ,  Junki Katsube ,  Hisao Yamamoto

    发明人： Atsuyuki Kojima ,  Tsunemasa Irie ,  Shuichi Harada ,  Yoshito Kameno ,  Junki Katsube ,  Hisao Yamamoto

    IPC分类号： C07C29/42 ,  C07D209/44 ,  C07D295/108 ,  C07D307/52 ,  C07D317/58 ,  C07D333/22 ,  A61K27/00 ,  A61K31/135 ,  A61K31/34 ,  A61K31/36 ,  A61K31/38 ,  A61K31/40 ,  A61K31/44 ,  A61K31/445

    CPC分类号： C07D295/108 ,  C07C29/42 ,  C07D209/44 ,  C07D307/52 ,  C07D317/58 ,  C07D333/22

    摘要： Conjugated ketone compounds of the formula: ##STR1## wherein Ar is naphthyl, furyl, thienyl, or phenyl optionally bearing one or more substituents selected from the group consisting of chlorine, bromine, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, trifluoromethyl and methylenedioxy, R.sub.1 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.5 alkenyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.7 -C.sub.8 aralkyl or adamantyl, R.sub.2 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.5 alkenyl or C.sub.3 -C.sub.6 cycloalkyl, or when R.sub.1 and R.sub.2 are taken together with the nitrogen atom to which they are attached, they form a heterocyclic amino group containing up to 8 carbon atoms, A is straight or branched C.sub.1 -C.sub.3 alkylene, N-[4-(p-chlorophenyl)-4-oxo-2-trans-butenyl]morpholine and N-[4-(p-methoxyphenyl)-4-oxo-2-trans-butenyl]piperidine being excluded, and their non-toxic salts, which are useful as blood platelet anti-aggregative agents.

    摘要翻译： 具有下式的共轭酮化合物：其中Ar是萘基，呋喃基，噻吩基或任选具有一个或多个选自氯，溴，C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4 烷基硫基，三氟甲基和亚甲二氧基，R 1是C 1 -C 6烷基，C 3 -C 5烯基，C 3 -C 6环烷基，C 7 -C 8芳烷基或金刚烷基，R 2是C 1 -C 6烷基，C 3 -C 5链烯基或C 3 -C 6环烷基， 并且R 2与它们所连接的氮原子一起形成含有至多8个碳原子的杂环氨基，A是直链或支链C1-C3亚烷基，N- [4-（对氯苯基）-4 - 氧代-2-反式 - 丁烯基]吗啉和N- [4-（对甲氧基苯基）-4-氧代-2-反式 - 丁烯基]哌啶，以及它们的无毒盐，其可用作血小板抗体 聚集代理。

    Novel cyclopropylmethylamine derivatives
    2.
    发明授权
    Novel cyclopropylmethylamine derivatives 失效
    新型环丙基甲胺衍生物

    公开(公告)号：US4103030A

    公开(公告)日：1978-07-25

    申请号：US635331

    申请日：1975-11-26

    申请人： Atsuyuki Kojima ,  Yoshito Kameno ,  Junki Katsube ,  Shigeho Inaba ,  Hisao Yamamoto

    发明人： Atsuyuki Kojima ,  Yoshito Kameno ,  Junki Katsube ,  Shigeho Inaba ,  Hisao Yamamoto

    IPC分类号： A61K31/13 ,  A61K31/135 ,  A01N9/20 ,  A01N9/24 ,  C07C91/16 ,  C07C91/28

    摘要： Novel cyclopropylmethylamine compounds of the formula: ##STR1## wherein Ar.sup.1 represents a phenyl group having one or more substituents selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy and trifluoromethyl, of which at least one is present at the o- or m-position, Ar.sup.2 represents an unsubstituted phenyl group or a phenyl group substituted with one or more substituents selected from the group consisting of halogen and C.sub.1 -C.sub.4 alkyl, R represents hydrogen, C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.4 hydroxyalkyl and R' represents C.sub.1 -C.sub.4 alkyl or C.sub.2 -C.sub.4 hydroxyalkyl, and their non-toxic salts, which possess various useful pharmacological activities and can be produced by reduction of the corresponding compounds of the formula: ##STR2## wherein Ar.sup.1, Ar.sup.2, R and R' are each as defined above or by condensation of the corresponding compounds of the formula: ##STR3## wherein Ar.sup.1 and Ar.sup.2 are each as defined above and X is a conventional leaving (removable) group with amines of the formula: ##STR4## wherein R and R' are each as defined above.

    摘要翻译： 新的下式的环丙基甲胺化合物：其中Ar 1表示具有一个或多个选自卤素，C 1 -C 4烷基，C 1 -C 4烷氧基和三氟甲基的取代基的苯基，其中至少一个存在于 或位置，Ar 2表示未取代的苯基或被一个或多个选自卤素和C 1 -C 4烷基的取代基取代的苯基，R表示氢，C 1 -C 4烷基或C 2 -C 4羟烷基， R'表示C1-C4烷基或C2-C4羟基烷基及其无毒盐，它们具有各种有用的药理活性，可以通过还原相应的下式化合物来制备：其中Ar1，Ar2，R和 R'各自如上所定义，或通过下式的相应化合物的缩合：其中Ar 1和Ar 2各自如上所定义，X是具有下式的胺的常规离去（可除去）基团：其中 R和R'各自如上所定义。

    Cyclopropylmethylamine derivatives
    3.
    发明授权
    Cyclopropylmethylamine derivatives 失效
    环丙基甲胺衍生物

    公开(公告)号：US4110376A

    公开(公告)日：1978-08-29

    申请号：US605012

    申请日：1975-08-15

    申请人： Atsuyuki Kojima ,  Junki Katsube ,  Yoshito Kameno ,  Shigeho Inaba ,  Hisao Yamamoto

    发明人： Atsuyuki Kojima ,  Junki Katsube ,  Yoshito Kameno ,  Shigeho Inaba ,  Hisao Yamamoto

    IPC分类号： A61K31/135 ,  A61K31/13 ,  C07C20060101 ,  C07C67/00 ,  C07C209/00 ,  C07C209/50 ,  C07C211/26 ,  C07C87/32

    CPC分类号： C07D401/12

    摘要： Novel cyclopropylmethylamine compounds of the formula: ##STR1## wherein R.sup.1 and R.sup.2 are each hydrogen or halogen and R.sup.3 is hydrogen or methyl, and their non-toxic salts, which possess various useful pharmacological activities and can be produced by reduction of the corresponding compounds of the formula: ##STR2## wherein R.sup.1, R.sup.2 and R.sup.3 are each as defined above or their non-toxic salts, or by condensation of the corresponding compounds of the formula: ##STR3## wherein R.sup.1 and R.sup.2 are each defined above, and X is a conventional interchangeable group such as halogen or sulfonyloxy with methylamine or dimethylamine.

    摘要翻译： 下式的新型环丙基甲胺化合物：其中R 1和R 2各自为氢或卤素，R 3为氢或甲基，及其无毒盐，其具有各种有用的药理活性，可通过还原相应化合物 其中R 1，R 2和R 3各自如上所定义，或其无毒盐，或通过下式的相应化合物的缩合：其中R 1和R 2各自如上所定义，X为 常规的可互换基团如卤素或磺酰氧基与甲胺或二甲胺。

    Novel morpholine derivatives and the treatment of mental depression
    4.
    发明授权
    Novel morpholine derivatives and the treatment of mental depression 失效
    新型吗啉衍生物和精神抑郁症的治疗

    公开(公告)号：US4085210A

    公开(公告)日：1978-04-18

    申请号：US646908

    申请日：1976-01-06

    申请人： Junki Katsube ,  Atsuyuki Kojima ,  Makoto Sunagawa ,  Yoshinori Takashima ,  Yoshito Kameno ,  Hisao Yamamoto

    发明人： Junki Katsube ,  Atsuyuki Kojima ,  Makoto Sunagawa ,  Yoshinori Takashima ,  Yoshito Kameno ,  Hisao Yamamoto

    IPC分类号： C07D265/30 ,  C07D267/10 ,  C07D409/06 ,  A61K31/535 ,  C07D405/06

    CPC分类号： C07D265/30 ,  C07D267/10

    摘要： Novel morpholine compounds of the formula: ##STR1## wherein R.sub.1 represents hydrogen or C.sub.1 -C.sub.4 alkyl, R.sub.2 represents hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.5 alkenyl, C.sub.3 -C.sub.5 alkynyl, aryl-(C.sub.1 -C.sub.4)alkyl, (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.4)alkyl, polyhalo(C.sub.2 -C.sub.4)alkyl or hydroxy(C.sub.2 -C.sub.4)alkyl, A represents straight or branched C.sub.2 -C.sub.4 alkylene, B represents a divalent radical selected from the group consisting of --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, ##STR2## --CH.sub.2 --O--, --CH.sub.2 --S--, --S-- and --O--, >D --E-- represents a trivalent radical selected from the group consisting of >CH--CH.sub.2 -- and >C.dbd.CH-- and C.sub.1 and C.sub.2 each represent 1,2-phenylene optionally substituted with one or more substituents selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy, and their non-toxic salts, which are useful as antidepressants and can be produced by various methods.

    摘要翻译： 式中：R1代表氢或C1-C4烷基，R2代表氢，C1-C4烷基，C3-C5烯基，C3-C5炔基，芳基 - （C1-C4）烷基，（C3 -C 6）环烷基（C 1 -C 4）烷基，多卤代（C 2 -C 4）烷基或羟基（C 2 -C 4）烷基，A表示直链或支链C 2 -C 4亚烷基，B表示选自-CH 2 -CH 2 - ， - CH = CH-， -CH 2 -O-，-CH 2 -S-，-S-和-O-，> D-E-代表选自下组的三价基团：CH -CH 2 - 和> C = CH-且C 1和C 2各自表示任选被一个或多个选自卤素，C 1 -C 4烷基和C 1 -C 4烷氧基的取代基取代的1,2-亚苯基，它们的无毒 盐，其可用作抗抑郁药并且可以通过各种方法制备。

    Novel morpholine derivatives and treating depression therewith
    5.
    发明授权
    Novel morpholine derivatives and treating depression therewith 失效
    新型吗啉衍生物和治疗抑郁症

    公开(公告)号：US4169146A

    公开(公告)日：1979-09-25

    申请号：US811944

    申请日：1977-06-30

    申请人： Junki Katsube ,  Atsuyuki Kojima ,  Makoto Sunagawa ,  Yoshinori Takashima ,  Yoshito Kameno ,  Hisao Yamamoto

    发明人： Junki Katsube ,  Atsuyuki Kojima ,  Makoto Sunagawa ,  Yoshinori Takashima ,  Yoshito Kameno ,  Hisao Yamamoto

    IPC分类号： C07D265/30 ,  C07D267/10 ,  A61K27/00

    CPC分类号： C07D265/30 ,  C07D267/10

    摘要： Novel morpholine compounds of the formula: ##STR1## wherein R.sub.1 represents hydrogen or C.sub.1 -C.sub.4 alkyl, R.sub.2 represents hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.5 alkenyl, C.sub.3 -C.sub.5 alkynyl, aryl-(C.sub.1 -C.sub.4)alkyl, (C.sub.3 -C.sub.6)cycloalkyl(C.sub.1 -C.sub.4)alkyl, polyhalo(C.sub.2 -C.sub.4) alkyl or hydroxy(C.sub.2 -C.sub.4)alkyl, A represents straight or branched C.sub.2 -C.sub.4 alkylene, B represents a divalent radical selected from the group consisting of --CH.sub.2 --CH.sub.2 --, --CH.dbd.CH--, ##STR2## --CH.sub.2 --O--, --CH.sub.2 --S--, --S-- and --O--, >D--E-- represents a trivalent radical selected from the group consisting of >CH--CH.sub.2 -- and >C.dbd.CH-- and C.sub.1 and C.sub.2 each represent 1,2-phenylene optionally substituted with one or more substituents selected from the group consisting of halogen, C.sub.1 -C.sub.4 alkyl and C.sub.1 -C.sub.4 alkoxy, and their non-toxic salts, which are useful as antidepressants and can be produced by various methods.

    摘要翻译： 式中：R1代表氢或C1-C4烷基，R2代表氢，C1-C4烷基，C3-C5烯基，C3-C5炔基，芳基 - （C1-C4）烷基，（C3 -C 6）环烷基（C 1 -C 4）烷基，多卤代（C 2 -C 4）烷基或羟基（C 2 -C 4）烷基，A表示直链或支链C 2 -C 4亚烷基，B表示选自-CH 2 -CH 2 - ， - CH = CH-， -CH 2 -O-，-CH 2 -S-，-S-和-O-，> DE-表示选自下组的三价基团：CH-CH 2 - 和> C = CH-和C1和C2各自表示任选被一个或多个选自卤素，C 1 -C 4烷基和C 1 -C 4烷氧基的取代基取代的1,2-亚苯基及其无毒盐， 其可用作抗抑郁药并且可以通过各种方法制备。

    Analgesic benzomorphan derivatives
    6.
    发明授权
    Analgesic benzomorphan derivatives 失效
    镇痛苯并吗啉衍生物

    公开(公告)号：US4241070A

    公开(公告)日：1980-12-23

    申请号：US736072

    申请日：1976-10-27

    申请人： Junki Katsube ,  Hiroyuki Mizote ,  Shuichi Harada ,  Hisao Yamamoto

    发明人： Junki Katsube ,  Hiroyuki Mizote ,  Shuichi Harada ,  Hisao Yamamoto

    IPC分类号： A61K31/435 ,  A61P25/04 ,  C07D221/26 ,  A61K31/445

    CPC分类号： C07D221/26 ,  Y02P20/55

    摘要： 2-Substituted-2'-methyl-6,7-benzomorphan derivatives of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen or C.sub.1 -C.sub.3 alkyl; and R.sub.3 is hydrogen, halogen or C.sub.1 -C.sub.3 alkyl, and pharmaceutically acceptable salts thereof, which are useful as non-addicting analgesics with sedative effects, are prepared by the reaction of a 6,7-benzomorphan derivative of the formula: ##STR2## wherein R.sub.1 and R.sub.2 are as defined above, with a reactive derivative of an alcohol compound of the formula: ##STR3## wherein X is an optionally protected carbonyl group; and R.sub.3 is as defined above, optionally followed by the elimination of the protective group of the carbonyl group, or by the oxidation of a 6,7-benzomorphan derivative of the formula: ##STR4## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined above.

    摘要翻译： 具有下式的2-取代的-2'-甲基-6,7-苯并吗啉衍生物：其中R 1和R 2各自为氢或C 1 -C 3烷基; 并且R3是氢，卤素或C1-C3烷基及其药学上可接受的盐，其可用作具有镇静作用的非上瘾止痛剂，通过下式的6,7-苯并吗啉衍生物的反应制备： [II]其中R1和R2如上所定义，与下式的醇化合物的反应性衍生物：其中X是任选被保护的羰基; 并且R 3如上所定义，任选地随后消除羰基的保护基，或通过下式的6,7-苯并吗啉衍生物的氧化：其中R 1，R 2和R 3是 如上所述。

    Benzisoxazole derivatives
    7.
    发明授权
    Benzisoxazole derivatives 失效
    苯并异恶唑衍生物

    公开(公告)号：US4217349A

    公开(公告)日：1980-08-12

    申请号：US919221

    申请日：1978-06-26

    申请人： Junki Katsube ,  Tsuyoshi Kobayashi ,  Katsumi Tamoto ,  Yoshiaki Takebayashi ,  Kikuo Sasajima ,  Shigeho Inaba ,  Hisao Yamamoto

    发明人： Junki Katsube ,  Tsuyoshi Kobayashi ,  Katsumi Tamoto ,  Yoshiaki Takebayashi ,  Kikuo Sasajima ,  Shigeho Inaba ,  Hisao Yamamoto

    IPC分类号： C07D261/20 ,  A61K31/535 ,  C07D413/06

    CPC分类号： C07D261/20

    摘要： Novel benzisoxazole compounds of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, ar(C.sub.1 -C.sub.3)alkoxy or halogen or, when taken together, they form C.sub.1 -C.sub.2 alkylenedioxy, Alk is C.sub.1 -C.sub.4 alkylene and A is a group of the formula: ##STR2## (wherein R.sub.3 and R.sub.4 are each C.sub.1 -C.sub.4 alkyl or, when taken together with the adjacent nitrogen atom, they represent a 5-6 membered nitrogen-containing heterocyclic ring which may contain any additional hetero atom and R.sub.5 is C.sub.1 -C.sub.4 alkyl or aryl), and non-toxic salts thereof, which possess various pharmaceutical activities.

    摘要翻译： 新的苯并恶唑化合物，其结构式如下：其中R 1和R 2各自为氢，C 1 -C 4烷基，C 1 -C 4烷氧基，芳（C 1 -C 3）烷氧基或卤素，或者一起形成C 1 -C 2亚烷基二氧基， Alk是C 1 -C 4亚烷基，A是下式的基团：其中R 3和R 4各自是C 1 -C 4烷基，或者当与相邻的氮原子一起时，它们代表5-6元含氮的 可含有任何另外的杂原子的杂环，R 5为C 1 -C 4烷基或芳基）及其无毒盐，其具有各种药物活性。

    9-Formyl-9,10-dihydro-9,10-methanoanthracene
    10.
    发明授权
    9-Formyl-9,10-dihydro-9,10-methanoanthracene 失效
    9-甲酰基-9,10-二氢-9,10-甲烷基蒽

    公开(公告)号：US4358620A

    公开(公告)日：1982-11-09

    申请号：US139740

    申请日：1980-04-14

    申请人： Makoto Sunagawa ,  Hiromi Sato ,  Junki Katsube ,  Hisao Yamamoto

    发明人： Makoto Sunagawa ,  Hiromi Sato ,  Junki Katsube ,  Hisao Yamamoto

    IPC分类号： C07C47/235 ,  C07C47/238 ,  C07C47/453 ,  C07C57/50 ,  C07C61/39 ,  C07D295/02 ,  C07D295/03 ,  C07D295/125 ,  C07C47/52

    CPC分类号： C07D295/03 ,  C07C47/235 ,  C07C47/238 ,  C07C47/453 ,  C07C57/50 ,  C07C61/39 ,  C07D295/125

    摘要： Novel 9-aminoalkyl-methanoanthracenes of the formula: ##STR1## wherein A is C.sub.1 -C.sub.4 alkylene or C.sub.3 -C.sub.4 alkenylene and R.sub.1 and R.sub.2 are each hydrogen, C.sub.1 -C.sub.4 alkyl, C.sub.3 -C.sub.4 alkenyl, C.sub.3 -C.sub.4 alkynyl, C.sub.3 -C.sub.6 cycloalkyl(C.sub.1 -C.sub.3)alkyl, ar(C.sub.1 -C.sub.3)alkyl or polyhalo(C.sub.2 -C.sub.4)alkyl or, when taken together with the adjacent nitrogen atom, they may form a 5 to 7-membered nitrogen-containing heterocyclic ring which may contain an additional hetero atom, and their non-toxic salts, which are useful as anti-anxiety, anti-depressant, major tranquilizer, anti-histamine and anti-allergy drugs and can be prepared through a novel key intermediate, i.e. 9-formyl-9,10-dihydro-9,10-methanoanthracene, by various methods.

    摘要翻译： 其中A为C 1 -C 4亚烷基或C 3 -C 4亚烯基，R 1和R 2各自为氢，C 1 -C 4烷基，C 3 -C 4烯基，C 3 -C 4炔基，C 3 -C 4炔基， C 1 -C 8环烷基（C 1 -C 3）烷基，芳（C 1 -C 3）烷基或多卤代（C 2 -C 4）烷基，或与相邻的氮原子一起形成5至7元含氮杂环， 可以含有另外的杂原子及其无毒盐，其可用作抗焦虑剂，抗抑郁剂，主要镇静剂，抗组胺和抗过敏药物，并且可以通过新的关键中间体即9- 甲酰基-9,10-二氢-9,10-甲基蒽，通过各种方法。