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13 条记录 (耗时 0.022 秒)

    Analgesic benzomorphan derivatives
    1.
    发明授权
    Analgesic benzomorphan derivatives 失效
    镇痛苯并吗啉衍生物

    公开(公告)号：US4241070A

    公开(公告)日：1980-12-23

    申请号：US736072

    申请日：1976-10-27

    申请人： Junki Katsube ,  Hiroyuki Mizote ,  Shuichi Harada ,  Hisao Yamamoto

    发明人： Junki Katsube ,  Hiroyuki Mizote ,  Shuichi Harada ,  Hisao Yamamoto

    IPC分类号： A61K31/435 ,  A61P25/04 ,  C07D221/26 ,  A61K31/445

    CPC分类号： C07D221/26 ,  Y02P20/55

    摘要： 2-Substituted-2'-methyl-6,7-benzomorphan derivatives of the formula: ##STR1## wherein R.sub.1 and R.sub.2 are each hydrogen or C.sub.1 -C.sub.3 alkyl; and R.sub.3 is hydrogen, halogen or C.sub.1 -C.sub.3 alkyl, and pharmaceutically acceptable salts thereof, which are useful as non-addicting analgesics with sedative effects, are prepared by the reaction of a 6,7-benzomorphan derivative of the formula: ##STR2## wherein R.sub.1 and R.sub.2 are as defined above, with a reactive derivative of an alcohol compound of the formula: ##STR3## wherein X is an optionally protected carbonyl group; and R.sub.3 is as defined above, optionally followed by the elimination of the protective group of the carbonyl group, or by the oxidation of a 6,7-benzomorphan derivative of the formula: ##STR4## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined above.

    摘要翻译： 具有下式的2-取代的-2'-甲基-6,7-苯并吗啉衍生物：其中R 1和R 2各自为氢或C 1 -C 3烷基; 并且R3是氢，卤素或C1-C3烷基及其药学上可接受的盐，其可用作具有镇静作用的非上瘾止痛剂，通过下式的6,7-苯并吗啉衍生物的反应制备： [II]其中R1和R2如上所定义，与下式的醇化合物的反应性衍生物：其中X是任选被保护的羰基; 并且R 3如上所定义，任选地随后消除羰基的保护基，或通过下式的6,7-苯并吗啉衍生物的氧化：其中R 1，R 2和R 3是 如上所述。

    Conjugated ketone compounds in preventing platelet thrombosis
    2.
    发明授权
    Conjugated ketone compounds in preventing platelet thrombosis 失效
    共轭酮化合物预防血小板血栓形成

    公开(公告)号：US4418079A

    公开(公告)日：1983-11-29

    申请号：US335522

    申请日：1981-12-29

    申请人： Atsuyuki Kojima ,  Tsunemasa Irie ,  Shuichi Harada ,  Yoshito Kameno ,  Junki Katsube ,  Hisao Yamamoto

    发明人： Atsuyuki Kojima ,  Tsunemasa Irie ,  Shuichi Harada ,  Yoshito Kameno ,  Junki Katsube ,  Hisao Yamamoto

    IPC分类号： C07C29/42 ,  C07D209/44 ,  C07D295/108 ,  C07D307/52 ,  C07D317/58 ,  C07D333/22 ,  A61K27/00 ,  A61K31/135 ,  A61K31/34 ,  A61K31/36 ,  A61K31/38 ,  A61K31/40 ,  A61K31/44 ,  A61K31/445

    CPC分类号： C07D295/108 ,  C07C29/42 ,  C07D209/44 ,  C07D307/52 ,  C07D317/58 ,  C07D333/22

    摘要： Conjugated ketone compounds of the formula: ##STR1## wherein Ar is naphthyl, furyl, thienyl, or phenyl optionally bearing one or more substituents selected from the group consisting of chlorine, bromine, C.sub.1 -C.sub.4 alkyl, C.sub.1 -C.sub.4 alkoxy, C.sub.1 -C.sub.4 alkylthio, trifluoromethyl and methylenedioxy, R.sub.1 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.5 alkenyl, C.sub.3 -C.sub.6 cycloalkyl, C.sub.7 -C.sub.8 aralkyl or adamantyl, R.sub.2 is C.sub.1 -C.sub.6 alkyl, C.sub.3 -C.sub.5 alkenyl or C.sub.3 -C.sub.6 cycloalkyl, or when R.sub.1 and R.sub.2 are taken together with the nitrogen atom to which they are attached, they form a heterocyclic amino group containing up to 8 carbon atoms, A is straight or branched C.sub.1 -C.sub.3 alkylene, N-[4-(p-chlorophenyl)-4-oxo-2-trans-butenyl]morpholine and N-[4-(p-methoxyphenyl)-4-oxo-2-trans-butenyl]piperidine being excluded, and their non-toxic salts, which are useful as blood platelet anti-aggregative agents.

    摘要翻译： 具有下式的共轭酮化合物：其中Ar是萘基，呋喃基，噻吩基或任选具有一个或多个选自氯，溴，C 1 -C 4烷基，C 1 -C 4烷氧基，C 1 -C 4 烷基硫基，三氟甲基和亚甲二氧基，R 1是C 1 -C 6烷基，C 3 -C 5烯基，C 3 -C 6环烷基，C 7 -C 8芳烷基或金刚烷基，R 2是C 1 -C 6烷基，C 3 -C 5链烯基或C 3 -C 6环烷基， 并且R 2与它们所连接的氮原子一起形成含有至多8个碳原子的杂环氨基，A是直链或支链C1-C3亚烷基，N- [4-（对氯苯基）-4 - 氧代-2-反式 - 丁烯基]吗啉和N- [4-（对甲氧基苯基）-4-氧代-2-反式 - 丁烯基]哌啶，以及它们的无毒盐，其可用作血小板抗体 聚集代理。

    Method and apparatus for deodorizing the dipping up system of a lavatory
    3.
    发明授权
    Method and apparatus for deodorizing the dipping up system of a lavatory 失效
    盥洗室浸渍系统除臭方法和设备

    公开(公告)号：US3943578A

    公开(公告)日：1976-03-16

    申请号：US497352

    申请日：1974-08-14

    申请人： Masami Miya ,  Masao Nagasaki ,  Shuichi Harada

    发明人： Masami Miya ,  Masao Nagasaki ,  Shuichi Harada

    IPC分类号： A47K11/02

    CPC分类号： A47K11/026

    摘要： The apparatus comprises a throttle valve comprising an upper cylindrical resilient deformable membrane having an upper flange at the upper end thereof and a lower cylindrical resilient deformable membrane having a lower flange at the lower end thereof and connected at its upper end to the lower end of the upper cylindrical membrane by a central flange. The upper flange is secured to the upper wall portion of the outer wall of the apparatus and the lower flange is secured to the lower wall portion of the outer wall with either one of the upper and lower cylindrical membranes being twisted by 180.degree. about its longitudinal axis so that the twisted membrane is closed. The upper end of the throttle valve is attached to the hole discharge of the lavatory bowl while the lower end is located above the excrement reservoir. The lower membrane is closed during the use by rotating the central flange to appropriate angular position so as to temporarily hold the faeces thereon while bad odor from the reservoir is prevented from rising therethrough. After use, the central flange is rotated so as to open the lower cylindrical membrane for discharging the faeces thereon into the reservoir while the upper cylindrical membrane is closed to prevent bad odor from rising into the lavatory room and prevent the faeces to be viewed by the user. After discharge of the faeces into the reservoir, the lower cylindrical membrane is closed by rotating the central flange to be ready for the next use. Various mechanisms for rotating the central flange is provided for facilitating the opening and closing of the cylindrical membranes.

    摘要翻译： 该装置包括节流阀，该节流阀包括上圆柱形弹性可变形膜，其上端具有上凸缘，下圆柱形弹性可变形膜在其下端具有下凸缘，并在其上端连接到下端 上部圆柱形膜由中心凸缘。 上凸缘固定到设备外壁的上壁部分，下凸缘固定在外壁的下壁部分上，上下圆柱形膜中的任一个围绕其纵向方向扭转180° 轴使得扭转的膜被关闭。 节流阀的上端安装在洗手盆的孔排出口，而下端位于排泄物储存器的上方。 在使用期间，下膜通过将中心凸缘旋转到适当的角度位置而关闭，以便临时保持其上的粪便，同时防止来自储存器的臭味从其中上升通过。 使用后，中心凸缘旋转以打开下部圆柱形膜，用于将粪便排放到储存器中，同时上部圆柱形膜关闭，以防止不良气味上升进入盥洗室，并防止粪便被观察到 用户。 在将粪便排放到储存器中之后，下部圆柱形膜通过旋转中心凸缘而关闭以备下次使用。 提供了用于旋转中心凸缘的各种机构，以便于圆柱形膜的打开和关闭。

    Webbing take-up device
    4.
    发明授权
    Webbing take-up device 有权
    织带收卷装置

    公开(公告)号：US07735767B2

    公开(公告)日：2010-06-15

    申请号：US11547782

    申请日：2005-03-07

    申请人： Takuhiro Saito ,  Katsuki Asagiri ,  Shuichi Harada ,  Shinji Mori ,  Fuminori Komiya ,  Tomonori Kimura ,  Hitoshi Takamatsu ,  Tomonori Nagata ,  Kazuhiko Aihara ,  Masaki Yasuda

    发明人： Takuhiro Saito ,  Katsuki Asagiri ,  Shuichi Harada ,  Shinji Mori ,  Fuminori Komiya ,  Tomonori Kimura ,  Hitoshi Takamatsu ,  Tomonori Nagata ,  Kazuhiko Aihara ,  Masaki Yasuda

    IPC分类号： B60R22/46

    CPC分类号： B60R22/44 ,  B60R22/4633 ,  B60R2022/4473

    摘要： A webbing take-up device (10, 100) is disclosed, wherein a motor (44) is provided directly below a take-up shaft (20) between a pair of leg plates (16, 18) with a rotary shaft (50) of the motor (44) disposed perpendicularly to the take-up shaft (20), and a clutch (26) is provided at one side of one leg plate (16). Further, a gear (76) of a motor gear portion (46) is removably connected to a worm gear (34) in a clutch gear portion (28), and a mounting stay (84) is detachably attached to a case (30) with screws (86), so that the motor (44) and the motor gear portion (46) can be detached independently of the case (30) while still being assembled together. Still further, a pretensioner mechanism (156) and a sensor mechanism (182) are provided at one end side of a spool (118), and an urging mechanism (136) is disposed at the other end side thereof.

    摘要翻译： 公开了一种织带卷绕装置（10,100），其中马达（44）直接设置在带有旋转轴（50）的一对腿板（16,18）之间的卷取轴（20）的正下方， 的电动机（44）垂直于卷取轴（20）设置，离合器（26）设置在一个支脚板（16）的一侧。 此外，马达齿轮部分（46）的齿轮（76）可拆卸地连接到离合器齿轮部分（28）中的蜗轮（34），并且安装支架（84）可拆卸地附接到壳体（30） 通过螺钉（86），使得马达（44）和马达齿轮部分（46）可以在仍被组装在一起的状态下独立于壳体（30）拆卸。 此外，在卷轴（118）的一端侧设置有预张紧机构（156）和传感器机构（182），并且在其另一端侧配置有推压机构（136）。

    Webbing Take-Up Device
    7.
    发明申请
    Webbing Take-Up Device 有权
    卷绕装置

    公开(公告)号：US20070278338A1

    公开(公告)日：2007-12-06

    申请号：US11547782

    申请日：2005-03-07

    申请人： Takuhiro Saito ,  Katsuki Asagiri ,  Shuichi Harada ,  Shinji Mori ,  Fuminori Komiya ,  Tomonori Kimura ,  Hitoshi Takamatsu ,  Tomonori Nagata ,  Kazuhiko Aihara ,  Masaki Yasuda

    发明人： Takuhiro Saito ,  Katsuki Asagiri ,  Shuichi Harada ,  Shinji Mori ,  Fuminori Komiya ,  Tomonori Kimura ,  Hitoshi Takamatsu ,  Tomonori Nagata ,  Kazuhiko Aihara ,  Masaki Yasuda

    IPC分类号： B60R22/44

    CPC分类号： B60R22/44 ,  B60R22/4633 ,  B60R2022/4473

    摘要： A webbing take-up device (10, 100) is disclosed, wherein a motor (44) is provided directly below a take-up shaft (20) between a pair of leg plates (16, 18) with a rotary shaft (50) of the motor (44) disposed perpendicularly to the take-up shaft (20), and a clutch (26) is provided at one side of one leg plate (16). Further, a gear (76) of a motor gear portion (46) is removably connected to a worm gear (34) in a clutch gear portion (28), and a mounting stay (84) is detachably attached to a case (30) with screws (86), so that the motor (44) and the motor gear portion (46) can be detached independently of the case (30) while still being assembled together. Still further, a pretensioner mechanism (156) and a sensor mechanism (182) are provided at one end side of a spool (118), and an urging mechanism (136) is disposed at the other end side thereof.

    摘要翻译： 公开了一种织带卷绕装置（10,100），其中马达（44）直接设置在带有旋转轴（50）的一对腿板（16,18）之间的卷取轴（20）的正下方， 的电动机（44）垂直于卷取轴（20）设置，离合器（26）设置在一个支脚板（16）的一侧。 此外，马达齿轮部分（46）的齿轮（76）可拆卸地连接到离合器齿轮部分（28）中的蜗轮（34），并且安装支架（84）可拆卸地附接到壳体（30） 通过螺钉（86），使得马达（44）和马达齿轮部分（46）可以在仍被组装在一起的状态下独立于壳体（30）拆卸。 此外，在卷轴（118）的一端侧设置有预张紧机构（156）和传感器机构（182），并且在其另一端侧配置有推压机构（136）。