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公开(公告)号：US07419663B2
公开(公告)日：2008-09-02
申请号：US10964263
申请日：2004-10-12
申请人： Avi Ashkenazi , Karim Yussef Helmy , Sherman Fong , Audrey Goddard , Austin L. Gurney , Kenneth James Katschke, Jr. , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
发明人： Avi Ashkenazi , Karim Yussef Helmy , Sherman Fong , Audrey Goddard , Austin L. Gurney , Kenneth James Katschke, Jr. , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K14/70503 , A61K2039/505 , C07K16/2803 , C07K2317/76 , C07K2319/30 , Y10S424/809 , Y10S424/81
摘要： The present invention concerns a recently discovered macrophage specific receptor, STIgMA, and its use in the treatment of complement-associated disorders.
摘要翻译： 本发明涉及最近发现的巨噬细胞特异性受体STIgMA及其在补体相关疾病的治疗中的应用。
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公开(公告)号：US20120189626A1
公开(公告)日：2012-07-26
申请号：US13327523
申请日：2011-12-15
申请人： Avi Ashkenazi , Karim Yussef Helmy , Sherman Fong , Audrey Goddard , Austin L. Gurney , Kenneth James Katschke, JR. , Menno Van Lookeren , William I. Wood
发明人： Avi Ashkenazi , Karim Yussef Helmy , Sherman Fong , Audrey Goddard , Austin L. Gurney , Kenneth James Katschke, JR. , Menno Van Lookeren , William I. Wood
IPC分类号： A61K39/395 , A61P17/00 , A61P17/06 , A61P37/08 , A61P41/00 , A61P27/02 , A61P13/12 , A61P11/06 , A61P3/10 , A61P29/00 , A61P1/00 , A61P37/02 , A61P7/06 , A61P25/00 , A61P31/14 , A61P31/12 , A61P11/00 , A61P9/00 , A61P19/02
CPC分类号： A61K38/177 , A61K38/17 , A61K38/1709 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2317/77 , C07K2319/30 , Y02A50/463 , A61K2300/00
摘要： The present invention concerns a recently discovered macrophage specific receptor, CRIg, and its use in the treatment of complement-associated disorders.
摘要翻译： 本发明涉及最近发现的巨噬细胞特异性受体CRIg及其在补体相关疾病的治疗中的应用。
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公开(公告)号：US08088386B2
公开(公告)日：2012-01-03
申请号：US11159919
申请日：2005-06-22
申请人： Avi Ashkenazi , Karim Yussef Helmy , Sherman Fong , Audrey Goddard , Austin L. Gurney , Kenneth James Katschke, Jr. , Menno Van Lookeren , William I. Wood
发明人： Avi Ashkenazi , Karim Yussef Helmy , Sherman Fong , Audrey Goddard , Austin L. Gurney , Kenneth James Katschke, Jr. , Menno Van Lookeren , William I. Wood
IPC分类号： A61K39/395
CPC分类号： A61K38/177 , A61K38/17 , A61K38/1709 , A61K2039/505 , C07K14/705 , C07K16/28 , C07K2317/77 , C07K2319/30 , Y02A50/463 , A61K2300/00
摘要： The present invention concerns a recently discovered macrophage specific receptor, CRIg, and its use in the treatment of complement-associated disorders.
摘要翻译： 本发明涉及最近发现的巨噬细胞特异性受体CRIg及其在补体相关疾病的治疗中的应用。
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公开(公告)号：US08007798B2
公开(公告)日：2011-08-30
申请号：US11249825
申请日：2005-10-12
申请人： Avi Ashkenazi , Karim Yussef Helmy , Sherman Fong , Audrey Goddard , Austin L. Gurney , Kenneth James Katschke, Jr. , Menno Van Lookeren , William I. Wood
发明人： Avi Ashkenazi , Karim Yussef Helmy , Sherman Fong , Audrey Goddard , Austin L. Gurney , Kenneth James Katschke, Jr. , Menno Van Lookeren , William I. Wood
IPC分类号： A61K39/395
CPC分类号： G01N33/57484 , A61K38/00 , C07K14/705 , C07K16/28 , C07K2317/24 , C07K2319/30 , G01N33/6893
摘要： The present invention concerns a recently discovered macrophage specific receptor, CRIg, and its use in the prevention and treatment of complement-associated disorders, including complement-associated eye conditions, such as age-related macular degeneration (AMD) and choroidal neovascularization (CNV).
摘要翻译： 本发明涉及最近发现的巨噬细胞特异性受体CRIg及其在预防和治疗补体相关疾病（包括补体相关性眼病）如年龄相关性黄斑变性（AMD）和脉络膜新生血管形成（CNV）中的用途。 。
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公开(公告)号：US20090275738A1
公开(公告)日：2009-11-05
申请号：US11725063
申请日：2007-03-15
申请人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
发明人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
IPC分类号： C07K19/00 , C07K14/435
CPC分类号： C07K14/705 , A61K2039/505 , C07K16/28 , C07K16/2803 , C07K2317/56 , C07K2319/30 , C12Q1/6883 , C12Q2600/158 , G01N33/564 , G01N33/566 , G01N33/574 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/705 , G01N2800/065 , G01N2800/102 , G01N2800/122 , G01N2800/127 , G01N2800/24
摘要： The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.
摘要翻译： 本发明涉及治疗和诊断疾病的组合物和方法，其特征在于与炎性疾病和/或癌症相关的抗原的存在。
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公开(公告)号：US20080312421A1
公开(公告)日：2008-12-18
申请号：US11725027
申请日：2007-03-15
申请人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
发明人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
CPC分类号： C07K14/705 , A61K2039/505 , C07K16/28 , C07K16/2803 , C07K2317/56 , C07K2319/30 , C12Q1/6883 , C12Q2600/158 , G01N33/564 , G01N33/566 , G01N33/574 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/705 , G01N2800/065 , G01N2800/102 , G01N2800/122 , G01N2800/127 , G01N2800/24
摘要： The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.
摘要翻译： 本发明涉及治疗和诊断疾病的组合物和方法，其特征在于与炎症性疾病和/或癌症相关的抗原的存在。
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公开(公告)号：US07741056B2
公开(公告)日：2010-06-22
申请号：US11725063
申请日：2007-03-15
申请人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
发明人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
CPC分类号： C07K14/705 , A61K2039/505 , C07K16/28 , C07K16/2803 , C07K2317/56 , C07K2319/30 , C12Q1/6883 , C12Q2600/158 , G01N33/564 , G01N33/566 , G01N33/574 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/705 , G01N2800/065 , G01N2800/102 , G01N2800/122 , G01N2800/127 , G01N2800/24
摘要： The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.
摘要翻译： 本发明涉及治疗和诊断疾病的组合物和方法，其特征在于与炎性疾病和/或癌症相关的抗原的存在。
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公开(公告)号：US07192589B2
公开(公告)日：2007-03-20
申请号：US10633008
申请日：2003-07-31
申请人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
发明人： Avi Ashkenazi , Sherman Fong , Audrey Goddard , Austin L. Gurney , Mary A. Napier , Daniel Tumas , Menno Van Lookeren , William I. Wood
CPC分类号： C07K14/705 , A61K2039/505 , C07K16/28 , C07K16/2803 , C07K2317/56 , C07K2319/30 , C12Q1/6883 , C12Q2600/158 , G01N33/564 , G01N33/566 , G01N33/574 , G01N33/57407 , G01N33/57492 , G01N33/6893 , G01N2333/705 , G01N2800/065 , G01N2800/102 , G01N2800/122 , G01N2800/127 , G01N2800/24
摘要： The present invention relates to compositions and methods of treating and diagnosing disorders characterized the by the presence of antigens associated with inflammatory diseases and/or cancer.
摘要翻译： 本发明涉及治疗和诊断疾病的组合物和方法，其特征在于与炎性疾病和/或癌症相关的抗原的存在。
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9.发明授权Pharmaceutical compositions, kits, and therapeutic uses of antagonist antibodies to IL-17E 有权IL-17E拮抗剂抗体的药物组合物，试剂盒和治疗用途公开(公告)号：US08034342B2
公开(公告)日：2011-10-11
申请号：US12549497
申请日：2009-08-28
申请人： Jian Chen , Ellen Filvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Sarah G. Hymowitz , Hanzhong Li , James Pan , Melissa A. Starovasnik , Daniel Tumas , Menno Van Lookeren , Richard Vandlen , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Daniel G. Yansura
发明人： Jian Chen , Ellen Filvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Sarah G. Hymowitz , Hanzhong Li , James Pan , Melissa A. Starovasnik , Daniel Tumas , Menno Van Lookeren , Richard Vandlen , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Daniel G. Yansura
IPC分类号： A61K39/00 , A61K39/395
CPC分类号： C07K16/244 , A61K38/00 , C07H21/04 , C07K14/54 , C07K14/7155 , C07K2317/21 , C07K2317/24 , C07K2317/35 , C07K2317/54 , C07K2317/55 , C07K2317/62 , G01N33/505 , G01N33/564 , G01N33/574 , G01N33/57407 , G01N33/57423 , G01N33/57438 , G01N33/57492 , G01N2333/54 , G01N2333/7155
摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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公开(公告)号：US20120064073A1
公开(公告)日：2012-03-15
申请号：US13270006
申请日：2011-10-10
申请人： Jian Chen , Ellen Fllvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Sarah G. Hymowitz , Hanzhong Li , James Pan , Melissa A. Starovasnik , Daniel Tumas , Menno Van Lookeren , Richard Vandlen , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Daniel G. Yansura
发明人： Jian Chen , Ellen Fllvaroff , Sherman Fong , Dorothy French , Audrey Goddard , Paul J. Godowski , J. Christopher Grimaldi , Austin L. Gurney , Kenneth J. Hillan , Sarah G. Hymowitz , Hanzhong Li , James Pan , Melissa A. Starovasnik , Daniel Tumas , Menno Van Lookeren , Richard Vandlen , Colin K. Watanabe , P. Mickey Williams , William I. Wood , Daniel G. Yansura
IPC分类号： A61K39/395 , A61P19/02 , A61P11/06 , A61P17/00 , A61P17/06 , A61P37/08 , A61P29/00 , A61P1/00
CPC分类号： C07K16/244 , A61K38/00 , C07H21/04 , C07K14/54 , C07K14/7155 , C07K2317/21 , C07K2317/24 , C07K2317/35 , C07K2317/54 , C07K2317/55 , C07K2317/62 , G01N33/505 , G01N33/564 , G01N33/574 , G01N33/57407 , G01N33/57423 , G01N33/57438 , G01N33/57492 , G01N2333/54 , G01N2333/7155
摘要： The present invention is directed to novel polypeptides having sequence identity with IL-17, IL-17 receptors and to nucleic acid molecules encoding those polypeptides. Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
摘要翻译： 本发明涉及与IL-17，IL-17受体和编码那些多肽的核酸分子具有序列同一性的新型多肽。 本文还提供了包含那些核酸序列的载体和宿主细胞，包含与异源多肽序列融合的本发明的多肽的嵌合多肽分子，与本发明的多肽结合的抗体以及本发明的多肽的制备方法 发明。 本文还提供了治疗退行性软骨疾病和其它炎性疾病的方法。
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