公开(公告)号：US06458529B1

公开(公告)日：2002-10-01

申请号：US08459994

申请日：1995-06-02

申请人： Axel Kahn ,  Gildas Le Gal la Salle ,  Jacques Mallet ,  Michel Perricaudet ,  Marc Peschanski ,  Jean-Jacques Robert

发明人： Axel Kahn ,  Gildas Le Gal la Salle ,  Jacques Mallet ,  Michel Perricaudet ,  Marc Peschanski ,  Jean-Jacques Robert

IPC分类号： C12Q168

CPC分类号： C12N15/86 ,  A61K38/185 ,  A61K38/44 ,  A61K38/47 ,  A61K48/00 ,  C12N9/0006 ,  C12N2710/10343 ,  C12N2830/008 ,  C12Y114/16002 ,  C12Y302/01051

摘要： The invention concerns a recombinant DNA vector characterized in that it is capable of directing the expression an/or transcription of a selected nucleotide sequence in the cells of the central nervous system and in that it comprises (i) at least part of the genome of an adenovirus, including the regions required for that adenovirus to penetrate into the cells normally infectable by that adenovirus and (ii) being inserted into said part of genome of an adenovirus under the control of a promoter, either present or also inserted into said genome part and operative in said cells. This recombinant vector finds particular use in the treatment of diseases of the central nervous system, also in gene therapy.

摘要翻译： 本发明涉及一种重组DNA载体，其特征在于其能够指导所选择的核苷酸序列在中枢神经系统的细胞中的表达/转录，并且其包含（i）至少部分基因组 腺病毒，其包括该腺病毒所需的区域穿透通常可被该腺病毒感染的细胞，和（ii）插入在启动子控制下的，存在于或也插入到所述基因组部分中的腺病毒的基因组的所述部分基因组中， 在所述细胞中起作用。 该重组载体特别用于治疗中枢神经系统疾病，也用于基因治疗。