-
1.发明授权Transgenic mammals having human Ig loci including plural VH and Vκ regions and antibodies produced therefrom 有权具有人Ig位点的转基因哺乳动物包括多个VH和V＆Kgr; 区域和抗体公开(公告)号：US08809051B2
公开(公告)日：2014-08-19
申请号：US11894779
申请日：2007-08-20
IPC分类号： C12N5/0735 , C12N5/0781 , C12N5/10 , A01K67/027
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A61K39/00 , C07K14/415 , C07K16/00 , C07K16/005 , C07K16/241 , C07K16/244 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/73 , C07K2317/92 , C12N15/8509 , C12N2800/206
摘要： The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VH and Vκ) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.
摘要翻译： 本发明涉及被工程化以含有人免疫球蛋白基因座的转基因非人动物。 特别地，根据本发明的动物具有包含多个可变（VH和V＆Kgr。）基因区的人Ig基因座。 有利地，包含多个可变区基因增强了由动物产生的人抗体的特异性和多样性。 此外，这些区域的包含增强和重建动物的B细胞发育，使得动物具有丰富的分泌极高亲和力抗体的成熟B细胞。
-
2.发明授权Transgenic mammals having human Ig loci including plural VH and VK regions and antibodies produced therefrom 失效具有人Ig基因座的转基因哺乳动物包括多个VH和VK区以及由其产生的抗体公开(公告)号：US07064244B2
公开(公告)日：2006-06-20
申请号：US10078958
申请日：2002-02-19
IPC分类号： A01K67/027 , A01K67/033 , C12P21/00
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A61K39/00 , C07K14/415 , C07K16/00 , C07K16/005 , C07K16/241 , C07K16/244 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/73 , C07K2317/92 , C12N15/8509 , C12N2800/206
摘要： The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VH and Vκ) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.
摘要翻译： 本发明涉及被工程化以含有人免疫球蛋白基因座的转基因非人动物。 特别地，根据本发明的动物具有包含多个可变（V H H P和V kappa）基因区的人Ig位点。 有利地，包含多个可变区基因增强了由动物产生的人抗体的特异性和多样性。 此外，这些区域的包含增强和重建动物的B细胞发育，使得动物具有丰富的分泌极高亲和力抗体的成熟B细胞。
-
搜索结果
2 条记录 (耗时 0.053 秒)
