-
1.发明授权Transgenic mammals having human Ig loci including plural VH and Vκ regions and antibodies produced therefrom 有权具有人Ig位点的转基因哺乳动物包括多个VH和V＆Kgr; 区域和抗体公开(公告)号：US08809051B2
公开(公告)日：2014-08-19
申请号：US11894779
申请日：2007-08-20
IPC分类号： C12N5/0735 , C12N5/0781 , C12N5/10 , A01K67/027
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A61K39/00 , C07K14/415 , C07K16/00 , C07K16/005 , C07K16/241 , C07K16/244 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/73 , C07K2317/92 , C12N15/8509 , C12N2800/206
摘要： The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VH and Vκ) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.
摘要翻译： 本发明涉及被工程化以含有人免疫球蛋白基因座的转基因非人动物。 特别地，根据本发明的动物具有包含多个可变（VH和V＆Kgr。）基因区的人Ig基因座。 有利地，包含多个可变区基因增强了由动物产生的人抗体的特异性和多样性。 此外，这些区域的包含增强和重建动物的B细胞发育，使得动物具有丰富的分泌极高亲和力抗体的成熟B细胞。
-
2.发明申请Transgenic mammals having human Ig loci including plural VH and VK regions and antibodies produced therefrom 有权具有人Ig基因座的转基因哺乳动物包括多个VH和VK区以及由其产生的抗体公开(公告)号：US20080235814A1
公开(公告)日：2008-09-25
申请号：US11250805
申请日：2005-10-14
IPC分类号： A01K67/027 , C12N5/06 , C12P21/08
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A61K39/00 , C07K14/415 , C07K16/00 , C07K16/005 , C07K16/241 , C07K16/244 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/73 , C07K2317/92 , C12N15/8509 , C12N2800/206
摘要： The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VH and Vκ) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.
摘要翻译： 本发明涉及被工程化以含有人免疫球蛋白基因座的转基因非人动物。 特别地，根据本发明的动物具有包含多个可变（V H H P和V kappa）基因区的人Ig位点。 有利地，包含多个可变区基因增强了由动物产生的人抗体的特异性和多样性。 此外，这些区域的包含增强和重建动物的B细胞发育，使得动物具有丰富的分泌极高亲和力抗体的成熟B细胞。
-
3.发明授权Transgenic mammals having human Ig loci including plural VH and VK regions and antibodies produced therefrom 失效具有人Ig基因座的转基因哺乳动物包括多个VH和VK区以及由其产生的抗体公开(公告)号：US07064244B2
公开(公告)日：2006-06-20
申请号：US10078958
申请日：2002-02-19
IPC分类号： A01K67/027 , A01K67/033 , C12P21/00
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A61K39/00 , C07K14/415 , C07K16/00 , C07K16/005 , C07K16/241 , C07K16/244 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/73 , C07K2317/92 , C12N15/8509 , C12N2800/206
摘要： The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VH and Vκ) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.
摘要翻译： 本发明涉及被工程化以含有人免疫球蛋白基因座的转基因非人动物。 特别地，根据本发明的动物具有包含多个可变（V H H P和V kappa）基因区的人Ig位点。 有利地，包含多个可变区基因增强了由动物产生的人抗体的特异性和多样性。 此外，这些区域的包含增强和重建动物的B细胞发育，使得动物具有丰富的分泌极高亲和力抗体的成熟B细胞。
-
4.发明申请Transgenic mammals having human Ig loci including plural Vh and Vk regions and antibodies produced therefrom 有权具有人Ig位点的转基因哺乳动物包括多个Vh和Vk区以及由其产生的抗体公开(公告)号：US20080098490A1
公开(公告)日：2008-04-24
申请号：US11894779
申请日：2007-08-20
IPC分类号： A01K67/00
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A61K39/00 , C07K14/415 , C07K16/00 , C07K16/005 , C07K16/241 , C07K16/244 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/73 , C07K2317/92 , C12N15/8509 , C12N2800/206
摘要： The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VH and Vκ) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.
摘要翻译： 本发明涉及被工程化以含有人免疫球蛋白基因座的转基因非人动物。 特别地，根据本发明的动物具有包含多个可变（V H H P和V kappa）基因区的人Ig位点。 有利地，包含多个可变区基因增强了由动物产生的人抗体的特异性和多样性。 此外，这些区域的包含增强和重建动物的B细胞发育，使得动物具有丰富的分泌极高亲和力抗体的成熟B细胞。
-
5.发明授权Transgenic mammals having human IG loci including plural Vh and Vk regions and antibodies produced therefrom 有权具有人IG基因座的转基因哺乳动物包括多个Vh和Vk区以及由其产生的抗体公开(公告)号：US07820877B2
公开(公告)日：2010-10-26
申请号：US11250805
申请日：2005-10-14
IPC分类号： A01K67/027 , C12P21/00
CPC分类号： A01K67/0278 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2217/075 , A01K2227/105 , A01K2267/01 , A61K39/00 , C07K14/415 , C07K16/00 , C07K16/005 , C07K16/241 , C07K16/244 , C07K16/2863 , C07K2317/21 , C07K2317/24 , C07K2317/73 , C07K2317/92 , C12N15/8509 , C12N2800/206
摘要： The present invention relates to transgenic non-human animals that are engineered to contain human immunoglobulin gene loci. In particular, animals in accordance with the invention possess human Ig loci that include plural variable (VH and Vκ) gene regions. Advantageously, the inclusion of plural variable region genes enhances the specificity and diversity of human antibodies produced by the animal. Further, the inclusion of such regions enhances and reconstitutes B-cell development to the animals, such that the animals possess abundant mature B-cells secreting extremely high affinity antibodies.
摘要翻译： 本发明涉及被工程化以含有人免疫球蛋白基因座的转基因非人动物。 特别地，根据本发明的动物具有包含多个可变（VH和V＆Kgr。）基因区的人Ig基因座。 有利地，包含多个可变区基因增强了由动物产生的人抗体的特异性和多样性。 此外，这些区域的包含增强和重建动物的B细胞发育，使得动物具有丰富的分泌极高亲和力抗体的成熟B细胞。
-
6.发明授权公开(公告)号：US09062113B2
公开(公告)日：2015-06-23
申请号：US12268363
申请日：2008-11-10
申请人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
发明人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/77 , C07K2317/92 , Y10S435/81
摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
-
公开(公告)号：US08431130B2
公开(公告)日：2013-04-30
申请号：US12843740
申请日：2010-07-26
申请人： Tariq Ghayur , Boris Labkovsky , Jeffrey W. Voss , Larry Green , John Babcook , Xiao-chi Jia , James Wieler , Jaspal Singh Kang , Brad Hedberg
发明人： Tariq Ghayur , Boris Labkovsky , Jeffrey W. Voss , Larry Green , John Babcook , Xiao-chi Jia , James Wieler , Jaspal Singh Kang , Brad Hedberg
IPC分类号： A61K39/395 , C07K16/18 , C07K16/24 , C12P21/08
CPC分类号： C07K16/244 , A61K2039/505 , C07H21/04 , C07K2317/21
摘要： The present invention encompasses IL-18 binding proteins, particularly antibodies that bind human interleukin-18 (hIL-18). Specifically, the invention relates to antibodies that are entirely human antibodies. Preferred antibodies have high affinity for hIL-18 and/or that neutralize hIL-18 activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Method of making and method of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hIL-18 and for inhibiting hIL-18 activity, e.g., in a human subject suffering from a disorder in which hIL-18 activity is detrimental.
摘要翻译： 本发明包括IL-18结合蛋白，特别是结合人白细胞介素-18（hIL-18）的抗体。 具体地，本发明涉及完全是人抗体的抗体。 优选的抗体对hIL-18具有高亲和力和/或在体外和体内中和hIL-18活性。 本发明的抗体可以是全长抗体或其抗原结合部分。 还提供了制备方法和使用本发明抗体的方法。 本发明的抗体或抗体部分可用于检测hIL-18和抑制hIL-18活性，例如在患有hIL-18活性有害的病症的人类受试者中。
-
公开(公告)号：US07566772B2
公开(公告)日：2009-07-28
申请号：US11335907
申请日：2006-01-19
申请人： Larry Green , Raffaella Faggioni , Orit Foord , Scott L. Klakamp , Giorgio Senaldi , Amy K. Schneider
发明人： Larry Green , Raffaella Faggioni , Orit Foord , Scott L. Klakamp , Giorgio Senaldi , Amy K. Schneider
IPC分类号： C07K16/24
CPC分类号： C07K16/245 , A61K2039/505 , C07K2317/21 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92 , Y10S424/801 , Y10S530/867
摘要： Antibodies directed to the antigen IL-1β and uses of such antibodies are described. In particular, fully human monoclonal antibodies directed to the antigen IL-1β. Nucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions and/or complementarity determining regions (CDR's), specifically from FR1 through FR4 or CDR1 through CDR3. Hybridomas or other cell lines expressing such immunoglobulin molecules and monoclonal antibodies.
摘要翻译： 描述针对抗原IL-1β的抗体和这种抗体的用途。 特别是针对抗原IL-1beta的完全人单克隆抗体。 编码的核苷酸序列和包含重链和轻链免疫球蛋白分子的氨基酸序列，特别是对应于跨越框架区和/或互补决定区（CDR）的连续重链和轻链序列的序列，特别是从FR1至FR4或CDR1至CDR3 。 表达这种免疫球蛋白分子和单克隆抗体的杂交瘤或其它细胞系。
-
公开(公告)号：US20070114377A1
公开(公告)日：2007-05-24
申请号：US11598873
申请日：2006-11-14
申请人： Kuangnan Qian , William Olmstead , Jason English , Larry Green , Roland Saeger , Stephen Jaffe
发明人： Kuangnan Qian , William Olmstead , Jason English , Larry Green , Roland Saeger , Stephen Jaffe
IPC分类号： B01D59/44
CPC分类号： G01N33/28 , G01N30/7206 , G01N2030/8854
摘要： The present invention is a method to determine the composition of a hydrocarbon feedstream from a small sample of hydrocarbons including the steps analyzing the sample with a combination of chromatograph and mass spectrometer, and reconciling output from step a) with other analytical measurements to determine to determine the composition of the hydrocarbon feedstream.
摘要翻译： 本发明是一种从小型烃类样品中确定烃类进料流的组成的方法，包括用色谱仪和质谱仪的组合分析样品的步骤，以及调节步骤a）的输出与其他分析测量结果，以确定 烃进料流的组成。
-
10.发明申请公开(公告)号：US20050053608A1
公开(公告)日：2005-03-10
申请号：US10877773
申请日：2004-06-25
申请人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal Kang , Chadwick King , Scott Klakamp , Qiaojuan Su
发明人： Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal Kang , Chadwick King , Scott Klakamp , Qiaojuan Su
IPC分类号： A61K39/395 , A61K47/48 , C07K16/22 , C07K16/28 , C07K17/00 , C12N20060101 , C12N5/06 , G01N33/53
CPC分类号： C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/77 , C07K2317/92 , Y10S435/81
摘要： The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
-
-
-
-
-
-
-
-
-
搜索结果
60 条记录 (耗时 0.048 秒)
