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公开(公告)号：US20050208039A1
公开(公告)日：2005-09-22
申请号：US10776773
申请日：2004-02-10
申请人： Aya Jakobovits , Robert Morrison , Arthur Raitano , Pia Challita-Eid , Juan Perez-Villar , Karen Morrison , Mary Faris , Wangmao Ge , Jean Gudas , Steven Kanner
发明人： Aya Jakobovits , Robert Morrison , Arthur Raitano , Pia Challita-Eid , Juan Perez-Villar , Karen Morrison , Mary Faris , Wangmao Ge , Jean Gudas , Steven Kanner
CPC分类号： C07K16/18 , A61K38/00 , A61K47/646 , A61K47/6813 , A61K51/1093 , C07K14/47 , C07K16/30 , C07K16/3038 , C07K2317/54 , C07K2317/55 , C07K2317/622 , G01N33/57484 , Y10T436/25
摘要： A novel gene (designated 158P1D7) and its encoded protein are described. While 158P1D7 exhibits tissue specific expression in normal adult tissue, it is aberrantly expressed in multiple cancers including set forth in Table 1. Consequently, 158P1D7 provides a diagnostic and/or therapeutic target for cancers. The 158P1D7 gene or fragment thereof, or its encoded protein or a fragment thereof, can be used to elicit an immune response.
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公开(公告)号：US20060275211A1
公开(公告)日：2006-12-07
申请号：US11396178
申请日：2006-03-31
申请人： Aya Jakobovits , Steven Kanner , Pia Challita-Eid , Juan Perez-Villar , Daulet Satpaev , Arthur Raitano , Robert Morrison , Karen Morrison , Xiao-Chi Jia , Jean Gudas
发明人： Aya Jakobovits , Steven Kanner , Pia Challita-Eid , Juan Perez-Villar , Daulet Satpaev , Arthur Raitano , Robert Morrison , Karen Morrison , Xiao-Chi Jia , Jean Gudas
IPC分类号： A61K51/00 , C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , A61K39/395 , C07K14/82 , C07K16/30 , C07K16/46
CPC分类号： C07K16/30 , A61K31/7088 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3061 , C07K16/3069 , C07K16/40 , C07K2317/20 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2319/30 , C12N9/16 , C12Q1/6886 , C12Q2600/158 , G01N33/57492 , Y02A50/466
摘要： Antibodies and molecules derived therefrom that bind to 161P2F10B protein and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
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3.发明申请公开(公告)号：US20070160530A1
公开(公告)日：2007-07-12
申请号：US11584413
申请日：2006-10-19
申请人： Aya Jakobovits , Soudabeh Etessami , Pia Challita-Eid , Juan Perez-Villar , Karen Morrison , Xiao-Chi Jia , Mary Faris , Jean Gudas , Arthur Raitano
发明人： Aya Jakobovits , Soudabeh Etessami , Pia Challita-Eid , Juan Perez-Villar , Karen Morrison , Xiao-Chi Jia , Mary Faris , Jean Gudas , Arthur Raitano
IPC分类号： A61K51/00 , C07H21/04 , C12P21/06 , A61K39/395 , A01K67/027
CPC分类号： C07K14/4748 , A01K67/0271 , A61K38/00 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/705 , C07K14/723 , C07K16/30 , C07K2317/34 , C07K2317/77 , C07K2319/00 , C12N9/0091 , G01N33/57484
摘要： Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits issue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.
摘要翻译： 其中描述了结合新型STEAP-1蛋白的抗体及其衍生物及其变体，其中STEAP-1在正常成人组织中表现出特异性表达，并且在表I中列出的癌症中异常表达。因此，STEAP-1 提供癌症的诊断，预后，预防和/或治疗靶标。 STEAP-1基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与STEAP-1反应的抗体或T细胞可用于主动或被动免疫。
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4.发明申请Nucleic acid and corresponding protein entitled 98P4B6 useful in treatment and detection of cancer 有权核酸和相应的蛋白质98P4B6可用于治疗和检测癌症公开(公告)号：US20050086707A1
公开(公告)日：2005-04-21
申请号：US10861662
申请日：2004-06-04
申请人： Aya Jakobovits , Soudabeh Etessami , Pia Challita-Eid , Juan Perez-Villar , Karen Morrison , Xiao-Chi Jia , Mary Faris , Jean Gudas , Arthur Raitano
发明人： Aya Jakobovits , Soudabeh Etessami , Pia Challita-Eid , Juan Perez-Villar , Karen Morrison , Xiao-Chi Jia , Mary Faris , Jean Gudas , Arthur Raitano
IPC分类号： A61K38/00 , A61K39/00 , C07K14/47 , C07K14/705 , C07K14/72 , C07K16/30 , G01N33/574 , C12Q1/68 , A01K67/027 , C07H21/04 , C12N9/64 , C12P21/04
CPC分类号： C07K14/4748 , A01K67/0271 , A61K38/00 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/705 , C07K14/723 , C07K16/30 , C07K2317/34 , C07K2317/77 , C07K2319/00 , C12N9/0091 , G01N33/57484
摘要： Antibodies and molecules derived therefrom that bind to novel STEAP-1 protein, and variants thereof, are described wherein STEAP-1 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, STEAP-1 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The STEAP-1 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with STEAP-1 can be used in active or passive immunization.
摘要翻译： 描述了结合于新型STEAP-1蛋白质的抗体和衍生自其的变体及其变体，其中STEAP-1在正常成人组织中显示组织特异性表达，并且在表I中列出的癌症中异常表达。因此，STEAP-1 提供癌症的诊断，预后，预防和/或治疗靶标。 STEAP-1基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与STEAP-1反应的抗体或T细胞可用于主动或被动免疫。
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5.发明申请Nucleic acids and corresponding proteins entitled 158P3D2 useful in treatment and detection of cancer 失效题为158P3D2的核酸和相应的蛋白质可用于治疗和检测癌症公开(公告)号：US20050191312A1
公开(公告)日：2005-09-01
申请号：US10994106
申请日：2004-11-19
申请人： Arthur Raitano , Aya Jakobovits , Pia Challita-Eid , Steven Kanner , Wangmao Ge , Juan Perez-Villar , Robert Morrison
发明人： Arthur Raitano , Aya Jakobovits , Pia Challita-Eid , Steven Kanner , Wangmao Ge , Juan Perez-Villar , Robert Morrison
CPC分类号： C07K14/4748 , A61K39/00 , C07K16/30
摘要： A novel gene 158P3D2 and its encoded protein, and variants thereof, are described wherein 158P3D2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 158P3D2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 158P3D2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 158P3D2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因158P3D2及其编码的蛋白及其变体，其中158P3D2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，158P3D2提供诊断，预后，预防和/ 或癌症的治疗靶标。 158P3D2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与158P3D2反应的抗体或T细胞可用于主动或被动免疫。
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6.发明申请Nucleic acid and corresponding protein entitled 184P1E2 useful in treatment and detection of cancer 失效核酸和相应的题为184P1E2的蛋白质可用于治疗和检测癌症公开(公告)号：US20070054284A1
公开(公告)日：2007-03-08
申请号：US11368284
申请日：2006-03-02
申请人： Pia Challita-Eid , Arthur Raitano , Mary Faris , Rene Hubert , Karen Morrison , Robert Morrison , Wangmao Ge , Aya Jakobovits
发明人： Pia Challita-Eid , Arthur Raitano , Mary Faris , Rene Hubert , Karen Morrison , Robert Morrison , Wangmao Ge , Aya Jakobovits
CPC分类号： C07K14/47 , A61K38/00 , C12N9/78 , Y10T436/25
摘要： A novel gene (designated 184P1E2) and its encoded protein, and variants thereof, are described wherein 184P1E2 exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 184P1E2 provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 184P1E2 gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 184P1E2 can be used in active or passive immunization.
摘要翻译： 描述了一种新型基因（称为184P1E2）及其编码的蛋白及其变体，其中184P1E2在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，184P1E2提供诊断，预后， 癌症的预防和/或治疗靶标。 184P1E2基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与184P1E2反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20070041968A1
公开(公告)日：2007-02-22
申请号：US11156231
申请日：2005-06-17
申请人： Aya Jakobovits , Pia Challita-Eid , Mary Faris , Wangmao Ge , Rene Hubert , Karen Morrison , Robert Morrison , Arthur Raitano , Daniel Afar
发明人： Aya Jakobovits , Pia Challita-Eid , Mary Faris , Wangmao Ge , Rene Hubert , Karen Morrison , Robert Morrison , Arthur Raitano , Daniel Afar
IPC分类号： A61K48/00 , A61K39/395 , C12N15/861
CPC分类号： C07K14/47 , A61K47/646 , A61K47/6851 , A61K47/6901 , A61K51/1045
摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.
摘要翻译： 图中指定和阐述的新基因。 2及其各自编码的蛋白质及其变体，其中本发明的基因在正常成人组织中表现出组织特异性表达，并且在诸如表I所列的癌症中异常表达。因此， 基因 2提供癌症的诊断，预后，预防和/或治疗靶点。 图1的基因 2或其片段，其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与图1的基因产物反应的抗体或T细胞。 2可用于主动或被动免疫。
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8.发明申请Nucleic acid and corresponding protein entitled 161P2F10B useful in treatment and detection of cancer 有权核酸和相应的标题为161P2F10B的蛋白质可用于治疗和检测癌症公开(公告)号：US20070212299A1
公开(公告)日：2007-09-13
申请号：US11655822
申请日：2007-01-19
申请人： Aya Jakobovits , Arthur Raitano , Mary Faris , Rene Hubert , Wangmao Ge , Karen Morrison , Robert Morrison , Pia Challita-Eid
发明人： Aya Jakobovits , Arthur Raitano , Mary Faris , Rene Hubert , Wangmao Ge , Karen Morrison , Robert Morrison , Pia Challita-Eid
IPC分类号： A61K51/00 , G01N33/574 , C07H21/04 , C12P21/06 , A61K39/395 , C07K14/82 , C07K16/30 , C07K16/46
CPC分类号： C07K16/30 , A61K31/7088 , A61K39/00 , A61K51/1045 , A61K2039/505 , C07K14/47 , C07K16/18 , C07K16/3023 , C07K16/303 , C07K16/3038 , C07K16/3046 , C07K16/3061 , C07K16/3069 , C07K16/40 , C07K2317/20 , C07K2317/33 , C07K2317/34 , C07K2317/54 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2319/30 , C12N9/16 , C12Q1/6886 , C12Q2600/158 , G01N33/57492 , Y02A50/466
摘要： A novel gene 0161P2F10B (also designated 161P2F10B) and its encoded protein, and variants thereof, are described wherein 161P2F10B exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers listed in Table I. Consequently, 161P2F10B provides a diagnostic, prognostic, prophylactic and/or therapeutic target for cancer. The 161P2F10B gene or fragment thereof, or its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with 161P2F10B can be used in active or passive immunization.
摘要翻译： 描述了新颖的基因0161P2F10B（也称为161P2F10B）及其编码的蛋白质及其变体，其中161P2F10B在正常成人组织中表现出组织特异性表达，并且在表I中列出的癌症中异常表达。因此，161P2F10B提供了诊断， 癌症的预后，预防和/或治疗靶标。 161P2F10B基因或其片段或其编码的蛋白质或其变体或其片段可用于引发体液或细胞免疫应答; 与161P2F10B反应的抗体或T细胞可用于主动或被动免疫。
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公开(公告)号：US20070048299A1
公开(公告)日：2007-03-01
申请号：US11155906
申请日：2005-06-17
申请人： Aya Jakobovits , Pia Challita-Eid , Mary Faris , Wangmao Ge , Rene Hubert , Karen Morrison , Robert Morrison , Arthur Raitano , Daniel Afar
发明人： Aya Jakobovits , Pia Challita-Eid , Mary Faris , Wangmao Ge , Rene Hubert , Karen Morrison , Robert Morrison , Arthur Raitano , Daniel Afar
IPC分类号： A61K39/395 , A61K48/00 , C12N15/861
CPC分类号： C07K14/47 , A61K47/646 , A61K47/6851 , A61K47/6901 , A61K51/1045
摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.
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公开(公告)号：US20070048283A1
公开(公告)日：2007-03-01
申请号：US11154298
申请日：2005-06-15
申请人： Aya Jakobovits , Pia Challita-Eid , Mary Faris , Wangmao Ge , Rene Hubert , Karen Morrison , Robert Morrison , Arthur Raitano , Daniel Afar
发明人： Aya Jakobovits , Pia Challita-Eid , Mary Faris , Wangmao Ge , Rene Hubert , Karen Morrison , Robert Morrison , Arthur Raitano , Daniel Afar
IPC分类号： A61K39/395 , A61K48/00
CPC分类号： C07K14/47 , A61K47/646 , A61K47/6851 , A61K47/6901 , A61K51/1045
摘要： Novel genes designated and set forth in FIG. 2 and their respective encoded proteins, and variants thereof, are described wherein a gene of the invention exhibits tissue specific expression in normal adult tissue, and is aberrantly expressed in the cancers such as those listed in Table I. Consequently, of gene products of a gene of FIG. 2 provide diagnostic, prognostic, prophylactic and/or therapeutic targets for cancer. A gene of FIG. 2 or fragment thereof, its encoded protein, or variants thereof, or a fragment thereof, can be used to elicit a humoral or cellular immune response; antibodies or T cells reactive with a gene product of FIG. 2 can be used in active or passive immunization.
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