公开(公告)号：US20040006306A1

公开(公告)日：2004-01-08

申请号：US10438266

申请日：2003-05-13

申请人： BACCHUS VASCULAR INC.

发明人： Michael A. Evans ,  Denise Demarais ,  Alexander Khairkhahan ,  Dino Decicco

IPC分类号： A61M029/00

CPC分类号： A61M25/1011 ,  A61B17/22 ,  A61B17/3207 ,  A61B17/320708 ,  A61B17/320725 ,  A61B2017/22038 ,  A61B2017/22039 ,  A61B2017/22042 ,  A61B2017/22061 ,  A61B2017/22067 ,  A61B2017/22084 ,  A61B2017/320733 ,  A61B2217/005 ,  A61M25/007 ,  A61M25/1002 ,  A61M2025/018 ,  A61M2025/1052

摘要： An apparatus for treating an occlusive region of a blood vessel includes a catheter including a first lumen extending from an end port to a first side port, and a second lumen extending from a proximal end of the catheter to a second side port. A balloon is mounted on the catheter between the first and second side ports. During use, a guidewire is placed into an occlusive region, and the guidewire is backloaded through the first and second lumens. The catheter is advanced over the guidewire, and the balloon is expanded to isolate the occlusive region. The guidewire is removed, and an agitator is advanced through the second lumen. After the agitator is agitated to dislodge occlusive material from the occlusive region, the agitator is removed, and the loose occlusive material is aspirated via the second side port.

摘要翻译： 用于治疗血管闭塞区域的装置包括导管，其包括从端口延伸到第一侧端口的第一腔，以及从导管的近端延伸到第二侧端口的第二腔。 气囊安装在第一和第二侧面之间的导管上。 在使用期间，将导丝放置在闭塞区域中，并且导丝通过第一和第二腔管被后加载。 导管在导线上前进，并且气囊膨胀以隔离闭塞区域。 引导线被移除，并且搅拌器前进通过第二管腔。 在搅动器搅动以从闭塞区域移除闭塞性材料之后，移除搅拌器，经由第二侧端口吸出松弛的封闭材料。

公开(公告)号：US20030139751A1

公开(公告)日：2003-07-24

申请号：US10278735

申请日：2002-10-21

申请人： BACCHUS VASCULAR INC.

发明人： Michael A. Evans ,  Denise Demarais ,  Dino De Cicco ,  Kelvin Ning ,  Alexander Khairkhahan ,  Tyler Jon Strang ,  Jody Maria Cimbalo ,  Stephen Leeflang

IPC分类号： A61B017/22

CPC分类号： A61B17/320758 ,  A61B17/22 ,  A61B17/22004 ,  A61B2017/00685 ,  A61B2017/22054 ,  A61B2017/22067 ,  A61B2017/22084 ,  A61B2017/320716 ,  A61B2017/320766 ,  A61M25/0021 ,  A61M25/007 ,  A61M25/0075 ,  A61M25/0105 ,  A61M39/22 ,  A61M2025/1052

摘要： Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, agitate the clot and agent, and aspirate broken-up clot from the blood vessel. A flow resistor in the catheter provides for infusion and/or aspiration to be concentrated primarily at a clot treatment area in a blood vessel while also providing optional infusion and/or aspiration distal to the treatment area. In some embodiments, infusion, aspiration and guidewire passage occur through a common lumen. The thrombolytic agent, such as tPA, streptokinase, or urokinase, is directly released into the clot at the point where the agitator is engaging the clot. In this way, the thrombolytic activity of the agent is enhanced and the dissolution of the clot is improved.

摘要翻译： 使用具有注入溶栓剂，搅动凝块和药剂的能力的导管，以及从血管中抽出破碎的凝块来实现凝块破裂和溶解。 导管中的流阻器提供输注和/或抽吸主要集中在血管中的凝块治疗区域，同时还提供可选的输液和/或远离治疗区域的抽吸。 在一些实施例中，输注，抽吸和导丝通过共同内腔。 血栓溶解剂如tPA，链激酶或尿激酶在搅拌器与凝块接合的位置处直接释放到凝块中。 以这种方式，药剂的溶栓活性增强，并且凝块的溶解得到改善。

公开(公告)号：US20020188276A1

公开(公告)日：2002-12-12

申请号：US10142005

申请日：2002-05-08

申请人： BACCHUS VASCULAR, INC.

发明人： Michael A. Evans ,  Denise Demarais ,  Dino De Cicco ,  Kelvin Ning ,  Alexander Khairkhahan ,  Tyler Jon Strang

IPC分类号： A61M029/00

CPC分类号： A61M25/0021 ,  A61B17/22 ,  A61B17/320725 ,  A61B17/320758 ,  A61B2017/22067 ,  A61B2017/22084 ,  A61M25/007 ,  A61M25/0105

摘要： Clot disruption and dissolution are achieved using a catheter having the ability to infuse a thrombolytic agent, aspirate clot and fluid, and allow passage of a guidewire. Optionally, the catheter may also include a mechanical agitator for further disrupt clot in the presence of the thrombolytic agent. A flow resistor in the catheter provides for infusion and/or aspiration to be concentrated primarily at a clot treatment area in a blood vessel while also providing optional infusion and/or aspiration distal to the treatment area. In some embodiments, infusion, aspiration and guidewire passage occur through a common lumen. The thrombolytic agent, such as tPA, streptokinase, or urokinase, is directly released into the clot at the point where the agitator is engaging the clot. In this way, the thrombolytic activity of the agent is enhanced and the dissolution of the clot is improved.

摘要翻译： 使用具有注入溶栓剂，抽吸凝块和流体并允许导丝通过的能力的导管实现凝块破裂和溶解。 任选地，导管还可以包括用于在溶栓剂存在下进一步破坏凝块的机械搅拌器。 导管中的流阻器提供输注和/或抽吸主要集中在血管中的凝块治疗区域，同时还提供可选的输液和/或远离治疗区域的抽吸。 在一些实施例中，输注，抽吸和导丝通过共同内腔。 血栓溶解剂如tPA，链激酶或尿激酶在搅拌器与凝块接合的位置处直接释放到凝块中。 以这种方式，药剂的溶栓活性增强，并且凝块的溶解得到改善。