公开(公告)号：US3821277A

公开(公告)日：1974-06-28

申请号：US86377069

申请日：1969-10-02

Applicant: BASF AG

Inventor： KOENIG H ,  METZGER H ,  WERNER R

IPC: C07C45/45 ,  C07C45/67 ,  C07C45/68 ,  C07C45/72 ,  C07C49/813 ,  C07C49/84 ,  C07C205/45 ,  C07C317/24 ,  C07C317/44 ,  C07C323/22 ,  C07C323/52 ,  C07C323/56 ,  C07C331/04 ,  C07D213/50 ,  C08G63/12 ,  C07C121/78

CPC classification number: C07C205/51 ,  C07C45/70 ,  C07C247/00 ,  C07C255/00 ,  C07C317/24 ,  C07C317/44 ,  C07C323/22 ,  C07C323/52 ,  C07C323/56 ,  C07C331/04 ,  C07D213/50 ,  C08G63/12 ,  C07C49/84

Abstract: Production of carbonyl compounds substituted in the Alpha position and having the formula

WHEREIN R1 is alkyl, aralkyl, phenyl, toluyl, naphthyl, alkoxy or amino; R2 is hydrogen,

A is hydrogen, alkyl, halo or

R6 is hydrogen or methyl; and R11 is alkyl, wherein said compounds are formed by reacting a sulfur ylide having the formula

WHEREIN Y is the radical

AND R9 and R10 are alkyl or phenyl, with a solution containing both an electrophilic agent A1 that is converted into the radical A and a nucleophilic agent B1 that is converted into the radical B; and said carbonyl compounds having the formula

WHEREIN Z is nitrile, carboxyl, or carboxyl esterified with an alkanol.

公开(公告)号：US3806509A

公开(公告)日：1974-04-23

申请号：US25136572

申请日：1972-05-08

Applicant: BASF AG

Inventor： SCHUSTER J ,  AMANN A ,  GIERTZ H ,  LEBKUECHER R ,  KOENIG H

IPC: A61K31/50 ,  C07D237/04 ,  C07D295/14 ,  C07D401/12 ,  C07D403/12 ,  C07D413/12 ,  C07D51/04

CPC classification number: C07D237/14

Abstract: NEW 6-ACYLAMINOPHENYL-4,5-DIHYDROPYRIDAZONES BEARING A SUBSTITUENT IN THE ACYL RADICAL, METHODS FOR THEIR PRODUCTION AND THEIR USE AS MEDICAMENTS, WHICH HAVE THE EFFECT OFLOWERING BLOOD PRESSURE, DILATING THE CARONARY ARTERIES AND COMBATTING INFLAMMATION.

公开(公告)号：US3843499A

公开(公告)日：1974-10-22

申请号：US33156073

申请日：1973-02-12

Applicant: BASF AG

Inventor： GIESE B ,  JAEGER P ,  KOENIG H ,  BRENNER K

IPC: C25B3/04 ,  B01J23/00 ,  C07B61/00 ,  C07C67/00 ,  C07C209/00 ,  C07C209/30 ,  C07C209/40 ,  C07C209/52 ,  C07C211/38 ,  C07B29/06 ,  C07C87/40

CPC classification number: C25B3/00

Abstract: 1. A PROCESS FOR THE PRODUCTION OF STERICALLY UNIFORM 4-ENDOTRICYCLO(5,2,10**2,6-ENDO)-DECYLAMINE WHICH COMPRISES: ELECTROCHEMICALLY REDUCING A COMPOUND OF THE FORMULA

2-(X-NH-)-PERHYDRO-4,7-METHANOINDENE

WHEREIN X IS HYDROGEN, HYDROXY OR -OCOR IN WHICH R IS LOWER ALKYL OF 1 TO 4 CARBON ATOMS, SAID REDUCTION BEING CARRIED OUT IN A LIQUID SOLVENT SELECTED FROM THE GROUP CONSISTING OF AN ORGANIC SOLVENT AND AN AQUEOUS ORGANIC SOLVENT REACTION MEDIUM AT A MERCURY, LEAD OR AMALGAM ELECTRODE AT A CURRENT DENSITY OF ABOUT 1 TO 20 AMPS/DM.2 AT A TEMPERATURE OF FROM -20*C. TO 40*C. AND A PH OF ABOUT 5 OR LESS; AND SEPARATING THE SUBSTANTIALLY STERICALLY UNIFORM AMINE PRODUCT FROM THE REACTION MEDIUM.

公开(公告)号：US3845050A

公开(公告)日：1974-10-29

申请号：US29595872

申请日：1972-10-10

Applicant: BASF AG

Inventor： SCHUSTER J ,  AMANN A ,  GIERTZ H ,  LEBKUECHER R ,  KOENIG H

IPC: C07D403/10 ,  A61K20060101 ,  C07D20060101 ,  C07D401/10 ,  C07D51/04

CPC classification number: C07D401/14

Abstract: 1. A COMPOUND OF THE FORMULA

1-R,3-((6-(O=)-1,4,5,6-TETRAHYDRO-PYRIDAZIN-3-YL)-(1,4-

PHENYLENE)-),4-(O=)-IMIDAZOLIDINE

IN WHICH R IS ALKYL OF 1 TO 8 CARBON ATOMS OR SAID ALKYL MONO SUBSTITUTED BY PHENYL, METHOXY, ETHOXY OR HYDROXY; CYCLOALKYL OF 5 TO 8 CARBON ATOMS; ALLYL; OR BUTYNYL; AND THE PHARMACEUTICALLY COMPATIBLE ACID ADDITION SALTS OF SAID COMPOUND.