公开(公告)号：US20220370993A1

公开(公告)日：2022-11-24

申请号：US17759397

申请日：2021-01-25

Applicant: BASF SE ,  THE REGENTS OF THE UNIVERSITY OF CALIFORNIA

Inventor： Omar M. Yaghi ,  Sonja Kuebelbeck ,  Grit Baier ,  Joshua C. Speros ,  Zhe Ji ,  Bing Zhang ,  Benjamin Breiten

IPC: B01J31/16 ,  B01J31/00 ,  C12N9/48 ,  C12N9/20 ,  C11D3/386

Abstract: Provided are compositions that include a metal-organic framework (MOF) including a framework defining an internal volume, an enzyme disposed within the internal volume, and a surfactant. Also provided are methods of making the compositions and their use.

公开(公告)号：US20210395650A1

公开(公告)日：2021-12-23

申请号：US17281496

申请日：2019-09-24

Applicant: BASF SE

Inventor： Stephan Hueffer ,  OLiver Spangenberg ,  Grit Baier ,  Alejandra Garcia Marcos ,  Claudia Esper

IPC: C11D3/386 ,  C12N9/96 ,  C12N9/64

Abstract: Described herein is an enzyme preparation including component (a): at least one compound according to general formula (I) wherein R1 is; R2, R3, R4 are independently from each other selected from the group consisting of H, linear C1-C8 alkyl, and branched C3-C8 alkyl, C6-C10-aryl, non-substituted or substituted with one or more carboxylate or hydroxyl groups, and C6-C10-aryl-alkyl, wherein an alkyl of the C6-C10-aryl-alkyl is selected from the group consisting of linear C1-C8 alkyl and branched C3-C8 alkyl, wherein at least one of R2, R3, and R4 is not H, component (b): at least one enzyme selected from the group consisting of hydrolases (EC 3); and optionally component (c): at least one compound selected from the group consisting of solvents, enzyme stabilizers different from component (a), and compounds stabilizing the enzyme preparation.

公开(公告)号：US20220284391A1

公开(公告)日：2022-09-08

申请号：US17632609

申请日：2020-09-10

Applicant: BASF SE

Inventor： Stefan Fischer ,  Jesper Nielsen ,  Simeon Sauer ,  Grit Baier

IPC: G06Q10/08 ,  G06Q50/28 ,  G01K3/04

Abstract: The present invention relates to a computer-implemented method for activity based enzyme formulation management of an enzyme formulation comprising (i) receiving input data, preferably via an input unit (10), of at least one storage segment data defined by at least temperature and storage duration and an initial enzyme activity value of said enzyme Predicted degradation formulation; (ii) determining, specifically calculating, a remaining activity value of the enzyme formulation based on the storage segment data and the initial enzyme activity value via a processing unit (20); (iii) providing a remaining activity value for the enzyme formulation, preferably via an output unit (30), and (iv) managing said enzyme formulation based on the remaining activity value of step (iii), said managing preferably comprising at least one of—providing a dosage recommendation based on the remaining activity value of the enzyme formulation, preferably via an output unit (30);—providing a residual shelf life indicator for said enzyme formulation based on the remaining activity value of the enzyme formulation; —automated adjustment of a dosage of the enzyme formulation by controlling of a dosing equipment; and/or—eliciting an order of a batch of enzyme formulation if the remaining activity value is indicative of the total enzyme activity in the enzyme formulation being below a pre- determined threshold value. The present invention also relates to an apparatus for activity based enzyme formulation management of an enzyme formulation, comprising: —an input unit (10) configured to receive a data input, preferably a user interface, wherein the data input comprises storage segment data defined by at least temperature and duration and an initial enzyme activity value of said enzyme formulation; —a processing unit (20), preferably a processing unit comprising at least one processor, configured, specifically by programming, to determine, specifically to calculate, a remaining activity value of the enzyme formulation based on the storage segment data and the initial enzyme activity value; and—an output unit (30) configured to output the remaining activity value for the enzyme formulation to the user and/or to a data interface.; and to a system comprising said apparatus. The present invention further relates to methods, computer programs, data carriers, and uses related to the aforesaid method, apparatus, and system.

公开(公告)号：US20210395651A1

公开(公告)日：2021-12-23

申请号：US17281803

申请日：2019-09-24

Applicant: BASF SE

Inventor： Stephan Hueffer ,  Alejandra Garcia Marcos ,  Sonja Kuebelbeck ,  Grit Baier ,  Oliver Spangenberg

IPC: C11D3/386 ,  C11D3/20 ,  C12N9/96 ,  C12N9/20

Abstract: Described herein is an enzyme preparation including component (a): at least one compound according to general formula (I) wherein R1 is H; R2, R3, R4 are independently from each other selected from the group consisting of H, linear C1-C8 alkyl, and branched C3-C8 alkyl, C6-C10-aryl, non-substituted or substituted with one or more carboxylate or hydroxyl groups, and C6-C10-aryl-alkyl, wherein an alkyl of the C6-C10-aryl-alkyl is selected from the group consisting of linear C1-C8 alkyl and branched C3-C8 alkyl, wherein at least one of R2, R3, and R4 is not H; component (b): at least one enzyme selected from the group consisting of hydrolases (EC 3); and optionally component (c): at least one compound selected from the group consisting of solvents, enzyme stabilizers different from component (a), and compounds stabilizing the enzyme preparation.