公开(公告)号：US09598428B2

公开(公告)日：2017-03-21

申请号：US14760302

申请日：2014-01-15

申请人： BASF SE

发明人： Melanie Bonnekessel ,  Wolfgang Reichert ,  Ralf Hoock ,  Thomas Kaeding ,  Christopher Koradin ,  Andreas Pletsch ,  Manfred Ehresmann ,  Hartwig Schroeder

IPC分类号： A01N43/90 ,  A01N53/00 ,  C07D493/04

CPC分类号： C07D493/04 ,  A01N43/90 ,  A01N53/00

摘要： The present invention relates to a method for preparing the pyripyropene compound of the formula (I) which method comprises the following steps: i) subjecting a pyripyropene compound of formula Pyripyropene A to an alkaline hydrolysis to yield a 1,7,11 -trideacetylpyripyropene A, ii) reacting 1,7,11-trideacetylpyripyropene A obtained in step i) with cyclopropane carbonyl chloride to yield a raw product containing the pyripyropene compound of formula (I); iii) subjecting the raw product of step ii) to crystallization to yield a crystalline pyripyropene compound of formula (I) and a mother liquor; and iv) recycling the mother liquor or a pyripyropene compound containing fraction thereof to the alkaline hydrolysis of step i).