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公开(公告)号:US20140364623A1
公开(公告)日:2014-12-11
申请号:US14371755
申请日:2012-12-13
Applicant: BASF SE
Inventor: Michael Keil , Wolfgang Reichert , Christopher Koradin , Yüksel Battal
IPC: C07D231/12 , C07C211/48
CPC classification number: C07D231/12 , C07C211/48
Abstract: The present invention relates to a novel process for preparing acetanilides of the formula (I) by reacting a 2-halo-N-halomethylacetanilide of the formula (II) with an azole of the formula (III) H-A (III) wherein the substituents R, R1, R2, R3, R4, A, X and X1 in the formulae (I), (II) and (III) have the meanings as indicated in the description.
Abstract translation: 本发明涉及一种通过使式(II)的2-卤代-N-卤代甲基乙酰苯胺与式(III)的唑(III)的反应制备式(I)的乙酰苯胺的新方法,其中取代基R 式(I),(II)和(III)中的R 1,R 2,R 3,R 4,A,X和X 1具有如说明书中所示的含义。
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公开(公告)号:US09598428B2
公开(公告)日:2017-03-21
申请号:US14760302
申请日:2014-01-15
Applicant: BASF SE
Inventor: Melanie Bonnekessel , Wolfgang Reichert , Ralf Hoock , Thomas Kaeding , Christopher Koradin , Andreas Pletsch , Manfred Ehresmann , Hartwig Schroeder
IPC: A01N43/90 , A01N53/00 , C07D493/04
CPC classification number: C07D493/04 , A01N43/90 , A01N53/00
Abstract: The present invention relates to a method for preparing the pyripyropene compound of the formula (I) which method comprises the following steps: i) subjecting a pyripyropene compound of formula Pyripyropene A to an alkaline hydrolysis to yield a 1,7,11 -trideacetylpyripyropene A, ii) reacting 1,7,11-trideacetylpyripyropene A obtained in step i) with cyclopropane carbonyl chloride to yield a raw product containing the pyripyropene compound of formula (I); iii) subjecting the raw product of step ii) to crystallization to yield a crystalline pyripyropene compound of formula (I) and a mother liquor; and iv) recycling the mother liquor or a pyripyropene compound containing fraction thereof to the alkaline hydrolysis of step i).
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