OBTAINING HIGHLY CONCENTRATED HMO SOLUTIONS BY REVERSE OSMOSIS

    公开(公告)号:US20230413838A1

    公开(公告)日:2023-12-28

    申请号:US18035307

    申请日:2021-11-05

    申请人: BASF SE

    IPC分类号: A23C9/142 C07H1/08

    CPC分类号: A23C9/142 C07H1/08

    摘要: The present invention relates to a method for concentrating aqueous solutions of human milk oligosaccharides, in which an aqueous solution comprising at least one human milk oligosaccharide is subjected to a reverse osmosis process by means of a reverse osmosis membrane and is thereby concentrated to a final osmotic pressure of at least 70 bar measured with a freezing point osmometer. Moreover, the present invention refers to an according use of a reverse osmosis membrane, a corresponding reverse osmosis system containing such a membrane and a spray-dried HMO product obtainable by the method.

    METHOD FOR OBTAINING CRYSTALLINE 2'-FUCOSYLLACTOSE

    公开(公告)号:US20210388014A1

    公开(公告)日:2021-12-16

    申请号:US17286474

    申请日:2019-10-17

    申请人: BASF SE

    IPC分类号: C07H1/08 C07H3/06

    摘要: The present invention relates to a method for obtaining crystalline 2′-fucosyllactose from a 2′-FL raw material, which contains 2′-FL as a main constituent and at least 0.5% by weight, frequently at least 1% by weight, in particular at least 2% by weight, more particularly at least 5% by weight, and especially at least 8% by weight,based on the total amount of mono-and oligosaccharides in the raw material, of one or more mono- or oligosaccharides different from 2′-FL, where the method comprises a)providing a solution of the 2′-FL raw material in water, which does not contain more than 10% by weight, preferably not more than 7% by weight, more preferably not more than 5% by weight of organic solvents, based on the total amount of water; b) effecting the crystallization of 2′-FL from the solution provided in step a) by inducing conditions of a controlled super saturation in the solution; and c) separating crystalline 2′-FL from the mother liquor, and where during controlled supersaturation in step b) not more than 10% by weight, preferably not more than 7% by weight, more preferably not more than 5% by weight of organic solvents are present, based on the total amount of water present during step b).