公开(公告)号：US20170312434A1

公开(公告)日：2017-11-02

申请号：US15652214

申请日：2017-07-17

Applicant: Battelle Memorial Institute

Inventor： Eric C. Scribben ,  Steven M. Risser ,  Amy M. Heintz ,  Jeffrey L. Ellis ,  John D. Clay ,  Timothy M. Blum

IPC: A61M5/20 ,  A61M5/19 ,  A61M5/28 ,  A61M5/31 ,  A61M5/315 ,  A61M5/24

CPC classification number: A61M5/20 ,  A61M5/19 ,  A61M5/204 ,  A61M5/2448 ,  A61M5/284 ,  A61M5/286 ,  A61M5/3134 ,  A61M5/31596 ,  A61M2005/247 ,  A61M2005/3128 ,  A61M2005/31598 ,  A61M2202/07 ,  A61M2206/18

Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.

公开(公告)号：US09737662B2

公开(公告)日：2017-08-22

申请号：US14356859

申请日：2012-11-07

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： Eric C. Scribben ,  John D. Clay ,  Jeffrey L. Ellis ,  Amy M. Heintz ,  Steven M. Risser ,  Timothy M. Blum

IPC: A61M5/20 ,  A61M5/19 ,  A61M5/28 ,  A61M5/24 ,  A61M5/31 ,  A61M5/315

CPC classification number: A61M5/20 ,  A61M5/19 ,  A61M5/204 ,  A61M5/2448 ,  A61M5/284 ,  A61M5/286 ,  A61M5/3134 ,  A61M5/31596 ,  A61M2005/247 ,  A61M2005/3128 ,  A61M2005/31598 ,  A61M2202/07 ,  A61M2206/18

Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.

公开(公告)号：US20200054831A1

公开(公告)日：2020-02-20

申请号：US16659592

申请日：2019-10-22

Applicant: Battelle Memorial Institute

Inventor： Eric C. Scribben ,  Steven M. Risser ,  Amy M. Heintz ,  Jeffrey L. Ellis ,  John D. Clay ,  Timothy M. Blum

IPC: A61M5/20 ,  A61M5/28 ,  A61M5/19

Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.

公开(公告)号：US11590285B2

公开(公告)日：2023-02-28

申请号：US16659592

申请日：2019-10-22

Applicant: Battelle Memorial Institute

Inventor： Eric C. Scribben ,  Steven M. Risser ,  Amy M. Heintz ,  Jeffrey L. Ellis ,  John D. Clay ,  Timothy M. Blum

IPC: A61M5/20 ,  A61M5/19 ,  A61M5/28 ,  A61M5/24 ,  A61M5/31 ,  A61M5/315

Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.

公开(公告)号：US20140324022A1

公开(公告)日：2014-10-30

申请号：US14356859

申请日：2012-11-07

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： Eric C. Scribben ,  Steven M. Risser ,  Amy M. Heintz ,  Jeffrey L. Ellis ,  John D. Clay ,  Timothy M. Blum

IPC: A61M5/20

CPC classification number: A61M5/20 ,  A61M5/19 ,  A61M5/204 ,  A61M5/2448 ,  A61M5/284 ,  A61M5/286 ,  A61M5/3134 ,  A61M5/31596 ,  A61M2005/247 ,  A61M2005/3128 ,  A61M2005/31598 ,  A61M2202/07 ,  A61M2206/18

Abstract: Core annular flow is used to enable the subcutaneous delivery of a viscous fluid such as a protein therapeutic formulation. The high-viscosity fluid is surrounded by a low-viscosity fluid, and the low-viscosity fluid lubricates the passage of the high-viscosity fluid. This allows the use of protein formulations that have a higher concentration and a higher viscosity at comparatively reduced injection forces and reduced injection times. Several different embodiments of injection devices that provide core annular flow are described herein.

Abstract translation: 核心环形流动用于使皮下递送粘性流体，例如蛋白质治疗剂型。 高粘度流体被低粘度流体包围，低粘度流体润滑高粘度流体的通道。 这允许使用在相对减少的注射力下降低注射时间的具有较高浓度和较高粘度的蛋白质制剂。 这里描述了提供芯环形流的注射装置的几个不同实施例。