公开(公告)号：US12109223B2

公开(公告)日：2024-10-08

申请号：US18444146

申请日：2024-02-16

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： Anthony D. Duong ,  Cherry Gupta ,  Kenneth R. Sims, Jr. ,  Danielle Huk ,  Jacob Lilly ,  Stephanie M. Kute ,  Mike Koeris

IPC: A61K47/60 ,  A61K31/7088 ,  A61K47/69 ,  C08F293/00 ,  C12N15/113 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00

CPC classification number: A61K31/7088 ,  A61K47/60 ,  A61K47/6935 ,  C08F293/005 ,  C12N15/113 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00 ,  C08F2438/03 ,  C12N2310/11 ,  C12N2310/531

Abstract: The invention relates to polymer nanoparticle and DNA nanostructure delivery compositions for non-viral delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticle delivery compositions, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, and DNA nanostructure delivery compositions, such as DNA origami compositions, for the delivery of more than one payload, or for the delivery of a nucleic acid construct payload of 3 kB or more, and methods therefor.