公开(公告)号：US20240074981A1

公开(公告)日：2024-03-07

申请号：US18332101

申请日：2023-06-09

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： Cherry Gupta ,  Julianne N.P. Smith ,  Miguel D. Pedrozo ,  Nickolas R. Andrioff ,  Morris O. Makobongo ,  Anthony D. Duong ,  Michael S. Koeris

IPC: A61K9/50 ,  A61K31/69 ,  A61K47/54 ,  A61P35/00

CPC classification number: A61K9/5031 ,  A61K31/69 ,  A61K47/549 ,  A61P35/00

Abstract: The invention relates to nucleic acid nanostructure delivery compositions for non-viral delivery, and methods therefor. More particularly, the invention relates to nucleic acid nanostructure delivery compositions, such as DNA origami compositions, for the delivery, for example, of small molecule therapeutics, and methods therefor.

公开(公告)号：US12109223B2

公开(公告)日：2024-10-08

申请号：US18444146

申请日：2024-02-16

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： Anthony D. Duong ,  Cherry Gupta ,  Kenneth R. Sims, Jr. ,  Danielle Huk ,  Jacob Lilly ,  Stephanie M. Kute ,  Mike Koeris

IPC: A61K47/60 ,  A61K31/7088 ,  A61K47/69 ,  C08F293/00 ,  C12N15/113 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00

CPC classification number: A61K31/7088 ,  A61K47/60 ,  A61K47/6935 ,  C08F293/005 ,  C12N15/113 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y35/00 ,  B82Y40/00 ,  C08F2438/03 ,  C12N2310/11 ,  C12N2310/531

Abstract: The invention relates to polymer nanoparticle and DNA nanostructure delivery compositions for non-viral delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticle delivery compositions, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, and DNA nanostructure delivery compositions, such as DNA origami compositions, for the delivery of more than one payload, or for the delivery of a nucleic acid construct payload of 3 kB or more, and methods therefor.

公开(公告)号：US12031128B2

公开(公告)日：2024-07-09

申请号：US17715784

申请日：2022-04-07

Applicant: BATTELLE MEMORIAL INSTITUTE

Inventor： Anthony D. Duong ,  Danielle J. Huk ,  Cherry Gupta ,  Kenneth R. Sims, Jr. ,  Michael S. Koeris ,  Zachary R. Shank ,  Ashlee J. Colbert ,  Andrea D. McCue ,  Emma K. Schmitz ,  Caleb T. Hillrich ,  Shannon D. Miller ,  Joanna L. Hoy

IPC: C12N15/10 ,  A61K48/00 ,  C12N15/88 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/682 ,  G01N33/53

CPC classification number: C12N15/1065 ,  A61K48/0041 ,  A61K48/0091 ,  C12N15/88 ,  C12Q1/6804 ,  C12Q1/6816 ,  C12Q1/682 ,  C12Q2525/301 ,  C12Q2525/313 ,  G01N33/5308

Abstract: The disclosure relates to barcoded polymer nanoparticles for in vivo screening and for in vivo therapeutic delivery, and methods therefor. More particularly, the invention relates to polymer nanoparticles, such as reversible addition-fragmentation chain transfer (RAFT) polymer compositions, associated with polynucleotide barcodes, for therapeutic delivery, and for high throughput in vivo screening of drug delivery nanoparticles.