公开(公告)号：US3630840A

公开(公告)日：1971-12-28

申请号：US3630840D

申请日：1970-03-13

Applicant: BAYER AG

Inventor： WAGNER OTTO ,  GEILHAUSEN HORST ,  BAHNEMANN HANS ,  SCHWECKENDIEK OTTO-ERICH

IPC: C12N7/00 ,  A61K39/12 ,  A61K39/135 ,  C12K7/00

CPC classification number: C12N7/00 ,  A61K39/12 ,  A61K39/135 ,  C12N2770/32134 ,  C12N2770/32151 ,  Y10S530/806 ,  Y10S530/826

Abstract: Foot-and-mouth disease virus solutions, used for the preparation of vaccines against the disease, are freed of undesirable protein contaminants accompanying the virus particles by subjecting the impure solution to fractional precipitation with polyethylene glycol solutions. The precipitate, containing the virus intigens is separated from the liquid phase which contains the proteins, preferably by centrifuging. The sediment consists of substantially purified virus antigen.