公开(公告)号：US11337973B2

公开(公告)日：2022-05-24

申请号：US16761713

申请日：2018-10-31

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

发明人： Nicole Biber ,  Damian Brockschnieder ,  Florian Kölling ,  Jörg Meding ,  Hideki Miyatake Ondozabal ,  Thomas Neubauer ,  Martina Schäfer ,  Dmitry Zubov ,  Carsten Terjung

IPC分类号： A61K31/4985 ,  C07D487/04 ,  A61P11/00 ,  A61K45/06

摘要： The invention relates to prolyl endopeptidase (PREP) inhibitors of formula (I) which contain a condensed 2,4-dihydro-3H-1,2,4-triazol-3-one ring system, methods for producing same, the use thereof alone or in combinations for treating and/or preventing diseases, and the use thereof for producing drugs for treating and/or preventing diseases, in particular for treating and/or preventing inflammatory lung diseases (COPD).

公开(公告)号：US10722501B2

公开(公告)日：2020-07-28

申请号：US16300480

申请日：2017-05-08

申请人： BAYER AKTIENGESELLSCHAFT ,  BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Nicole Biber ,  Damian Brockschnieder ,  Kersten Matthias Gericke ,  Florian Kölling ,  Klemens Lustig ,  Jörg Meding ,  Heinrich Meier ,  Thomas Neubauer ,  Martina Schäfer ,  Andreas Timmermann ,  Dmitry Zubov ,  Carsten Terjung ,  Niels Lindner ,  Volker Badock ,  Dieter Moosmayer ,  Hideki Miyatake Ondozabal ,  Stephen Moore ,  Alexander Schulz

IPC分类号： A61K31/437 ,  A61K31/506 ,  C07D471/04 ,  A61K31/4375 ,  A61K31/4709 ,  A61K31/497 ,  C07D519/00 ,  A61K45/06 ,  A61K31/444 ,  A61P11/00 ,  A61P29/00

摘要： The present application relates to novel substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones of formula (I), to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of lung inflammation disorders.

公开(公告)号：US09771352B2

公开(公告)日：2017-09-26

申请号：US14930157

申请日：2015-11-02

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Carsten Schmeck ,  Michael Gerisch ,  Nils Griebenow ,  Peter Kolkhof ,  Florian Kölling ,  Anna Engelen ,  Axel Kretschmer ,  Dieter Lang ,  Klemens Lustig ,  Thomas Mondritzki ,  Elisabeth Pook ,  Hartmut Beck ,  Frank Süβmeier ,  Sonja Vollmer ,  Pierre Wasnaire

IPC分类号： C07D403/06 ,  A61K31/4196 ,  A61K45/06

CPC分类号： C07D249/12 ,  A61K31/4196 ,  A61K45/06 ,  C07D403/06

摘要： The present invention relates to novel 5-(hydroxyalkyl)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of cardiovascular and renal diseases.