公开(公告)号：US11787797B2

公开(公告)日：2023-10-17

申请号：US17161615

申请日：2021-01-28

申请人： BAYER AKTIENGESELLSCHAFT ,  BAYER PHARMA AKTIENGESELLSCHAFT ,  THE BROAD INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  THE GENERAL HOSPITAL CORPORATION

发明人： Stefan Nikolaus Gradl ,  Duy Nguyen ,  Knut Eis ,  Judith Günther ,  Timo Stellfeld ,  Andreas Janzer ,  Sven Christian ,  Thomas Mueller ,  Sherif El Sheikh ,  Han Jie Zhou ,  Changjia Zhao ,  David B. Sykes ,  Steven James Ferrara ,  Kery Liu ,  Simon Anthony Herbert ,  Claudia Merz ,  Michael Niehues ,  Carl Friedrich Nising ,  Martina Schäfer ,  Katja Zimmermann ,  Jörg Knäblein ,  Kai Thede ,  Thomas Faupel

IPC分类号： C07D471/04 ,  A61P35/00 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C12N1/20 ,  C12P17/18

CPC分类号： C07D471/04 ,  A61P35/00 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C12N1/20 ,  C12P17/18 ,  C12P17/182 ,  C12P17/188

摘要： The present invention provides triazolone compounds of general formula (I):




in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

公开(公告)号：US10968216B2

公开(公告)日：2021-04-06

申请号：US16345178

申请日：2017-10-25

申请人： BAYER AKTIENGESELLSCHAFT ,  BAYER PHARMA AKTIENGESELLSCHAFT ,  THE BROAD INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  THE GENERAL HOSPITAL CORPORATION

发明人： Stefan Nikolaus Gradl ,  Duy Nguyen ,  Knut Eis ,  Judith Günther ,  Timo Stellfeld ,  Andreas Janzer ,  Sven Christian ,  Thomas Mueller ,  Sherif El Sheikh ,  Han Jie Zhou ,  Changjia Zhao ,  David B. Sykes ,  Steven James Ferrara ,  Kery Liu ,  Simon Anthony Herbert ,  Claudia Merz ,  Michael Niehues ,  Carl Friedrich Nising ,  Martina Schäfer ,  Katja Zimmermann ,  Jörg Knäblein ,  Kai Thede ,  Thomas Faupel

IPC分类号： C07D471/04 ,  A61P35/00 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C12N1/20 ,  C12P17/18

摘要： The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.