公开(公告)号：US11713304B2

公开(公告)日：2023-08-01

申请号：US17407951

申请日：2021-08-20

申请人： BAYER AKTIENGESELLSCHAFT ,  BAYER PHARMA AKTIENGESELLSCHAFT ,  THE BROAD INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  THE GENERAL HOSPITAL CORPORATION

发明人： Stefan Nikolaus Gradl ,  Duy Nguyen ,  Knut Eis ,  Judith Günther ,  Timo Stellfeld ,  Andreas Janzer ,  Sven Christian ,  Thomas Müller ,  Sherif El Sheikh ,  David B. Sykes ,  Steven James Ferrara ,  Michael Kröber ,  Claudia Merz ,  Michael Niehues ,  Martina Schäfer ,  Katja Zimmermann ,  Carl Friedrich Nising

IPC分类号： A61P35/00 ,  C07D401/12 ,  C07D249/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  A61K45/06

CPC分类号： C07D401/12 ,  A61P35/00 ,  C07D249/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  A61K45/06

摘要： The present invention provides triazolone compounds of general formula (I):




in which R1, R2, R3, R4, and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and prophylaxis of diseases, in particular hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

公开(公告)号：US10968216B2

公开(公告)日：2021-04-06

申请号：US16345178

申请日：2017-10-25

申请人： BAYER AKTIENGESELLSCHAFT ,  BAYER PHARMA AKTIENGESELLSCHAFT ,  THE BROAD INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  THE GENERAL HOSPITAL CORPORATION

发明人： Stefan Nikolaus Gradl ,  Duy Nguyen ,  Knut Eis ,  Judith Günther ,  Timo Stellfeld ,  Andreas Janzer ,  Sven Christian ,  Thomas Mueller ,  Sherif El Sheikh ,  Han Jie Zhou ,  Changjia Zhao ,  David B. Sykes ,  Steven James Ferrara ,  Kery Liu ,  Simon Anthony Herbert ,  Claudia Merz ,  Michael Niehues ,  Carl Friedrich Nising ,  Martina Schäfer ,  Katja Zimmermann ,  Jörg Knäblein ,  Kai Thede ,  Thomas Faupel

IPC分类号： C07D471/04 ,  A61P35/00 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C12N1/20 ,  C12P17/18

摘要： The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

公开(公告)号：US11787797B2

公开(公告)日：2023-10-17

申请号：US17161615

申请日：2021-01-28

申请人： BAYER AKTIENGESELLSCHAFT ,  BAYER PHARMA AKTIENGESELLSCHAFT ,  THE BROAD INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  THE GENERAL HOSPITAL CORPORATION

发明人： Stefan Nikolaus Gradl ,  Duy Nguyen ,  Knut Eis ,  Judith Günther ,  Timo Stellfeld ,  Andreas Janzer ,  Sven Christian ,  Thomas Mueller ,  Sherif El Sheikh ,  Han Jie Zhou ,  Changjia Zhao ,  David B. Sykes ,  Steven James Ferrara ,  Kery Liu ,  Simon Anthony Herbert ,  Claudia Merz ,  Michael Niehues ,  Carl Friedrich Nising ,  Martina Schäfer ,  Katja Zimmermann ,  Jörg Knäblein ,  Kai Thede ,  Thomas Faupel

IPC分类号： C07D471/04 ,  A61P35/00 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C12N1/20 ,  C12P17/18

CPC分类号： C07D471/04 ,  A61P35/00 ,  C07D487/04 ,  C07D498/04 ,  C07D513/04 ,  C07D519/00 ,  C12N1/20 ,  C12P17/18 ,  C12P17/182 ,  C12P17/188

摘要： The present invention provides triazolone compounds of general formula (I):




in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

公开(公告)号：US11130745B2

公开(公告)日：2021-09-28

申请号：US16996721

申请日：2020-08-18

申请人： BAYER AKTIENGESELLSCHAFT ,  BAYER PHARMA AKTIENGELLSCHAFT ,  THE BROAD INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  THE GENERAL HOSPITAL CORPORATION

发明人： Stefan Nikolaus Gradl ,  Duy Nguyen ,  Knut Eis ,  Judith Günther ,  Timo Stellfeld ,  Andreas Janzer ,  Sven Christian ,  Thomas Müller ,  Sherif El Sheikh ,  David B. Sykes ,  Steven James Ferrara ,  Michael Kröber ,  Claudia Merz ,  Michael Niehues ,  Martina Schäfer ,  Katja Zimmermann ,  Carl Friedrich Nising

IPC分类号： A61P35/00 ,  A61K45/06 ,  C07D401/12 ,  C07D249/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12

摘要： The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

公开(公告)号：US10815215B2

公开(公告)日：2020-10-27

申请号：US16345168

申请日：2017-10-25

申请人： BAYER AKTIENGESELLSCHAFT ,  BAYER PHARMA AKTIENGELLSCHAFT ,  THE BROAD INSTITUTE, INC. ,  PRESIDENT AND FELLOWS OF HARVARD COLLEGE ,  THE GENERAL HOSPITAL CORPORATION

发明人： Stefan Nikolaus Gradl ,  Duy Nguyen ,  Knut Eis ,  Judith Günther ,  Timo Stellfeld ,  Andreas Janzer ,  Sven Christian ,  Thomas Müller ,  Sherif El Sheikh ,  Han Jie Zhou ,  Changjia Zhao ,  David B. Sykes ,  Steven James Ferrara ,  Kery Liu ,  Michael Kröber ,  Claudia Merz ,  Michael Niehues ,  Martina Schäfer ,  Katja Zimmermann ,  Carl Friedrich Nising

IPC分类号： C07D401/12 ,  A61P35/00 ,  C07D249/12 ,  C07D403/12 ,  C07D405/12 ,  C07D413/12 ,  A61K45/06

摘要： The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.

公开(公告)号：US20150152050A1

公开(公告)日：2015-06-04

申请号：US14402232

申请日：2013-05-17

申请人： Bayer Pharma Aktiengesellschaft

发明人： Thomas Lampe ,  Michael Hahn ,  Johannes-Peter Stasch ,  Karl-Heinz Schlemmer ,  Frank Wunder ,  Sherif El Sheikh ,  Volkhart Min-Jian Li ,  Eva Maria Becker-Pelster ,  Friederike Stoll ,  Andreas Knorr

IPC分类号： C07D211/14 ,  A61K45/06 ,  A61K31/472 ,  A61K31/438 ,  A61K31/451 ,  C07D217/04 ,  A61K31/445 ,  C07D221/20

CPC分类号： C07D211/14 ,  A61K31/438 ,  A61K31/445 ,  A61K31/451 ,  A61K31/472 ,  A61K45/06 ,  C07D211/06 ,  C07D211/18 ,  C07D211/46 ,  C07D217/04 ,  C07D221/20 ,  C07D295/15

摘要： The present application relates to novel substituted 2-(piperidin-1-yl)acetamide derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular diseases.

摘要翻译： 本申请涉及新型取代的2-（哌啶-1-基）乙酰胺衍生物，其制备方法及其用于治疗和/或预防疾病的用途，以及其用于生产用于治疗和 /或预防疾病，特别是用于治疗和/或预防心血管疾病。

公开(公告)号：US09309198B2

公开(公告)日：2016-04-12

申请号：US14402232

申请日：2013-05-17

申请人： Bayer Pharma Aktiengesellschaft

发明人： Thomas Lampe ,  Michael Hahn ,  Johannes-Peter Stasch ,  Karl-Heinz Schlemmer ,  Frank Wunder ,  Sherif El Sheikh ,  Volkhart Min-Jian Li ,  Eva Maria Becker-Pelster ,  Friederike Stoll ,  Andreas Knorr

IPC分类号： C07D211/14 ,  C07D217/04 ,  C07D221/06 ,  A61K31/445 ,  A61K31/451 ,  A61K31/472 ,  C07D221/20 ,  C07D211/06 ,  C07D211/18 ,  C07D211/46 ,  C07D295/15 ,  A61K31/438 ,  A61K45/06

CPC分类号： C07D211/14 ,  A61K31/438 ,  A61K31/445 ,  A61K31/451 ,  A61K31/472 ,  A61K45/06 ,  C07D211/06 ,  C07D211/18 ,  C07D211/46 ,  C07D217/04 ,  C07D221/20 ,  C07D295/15

摘要： The present application relates to novel substituted 2-(piperidin-1-yl)acetamide derivatives, to processes for preparation thereof, to the use thereof for treatment and/or prevention of diseases, and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of cardiovascular diseases.

摘要翻译： 本申请涉及新型取代的2-（哌啶-1-基）乙酰胺衍生物，其制备方法及其用于治疗和/或预防疾病的用途，以及其用于生产用于治疗和 /或预防疾病，特别是用于治疗和/或预防心血管疾病。