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公开(公告)号：US11713304B2
公开(公告)日：2023-08-01
申请号：US17407951
申请日：2021-08-20
申请人： BAYER AKTIENGESELLSCHAFT , BAYER PHARMA AKTIENGESELLSCHAFT , THE BROAD INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE GENERAL HOSPITAL CORPORATION
发明人： Stefan Nikolaus Gradl , Duy Nguyen , Knut Eis , Judith Günther , Timo Stellfeld , Andreas Janzer , Sven Christian , Thomas Müller , Sherif El Sheikh , David B. Sykes , Steven James Ferrara , Michael Kröber , Claudia Merz , Michael Niehues , Martina Schäfer , Katja Zimmermann , Carl Friedrich Nising
IPC分类号： A61P35/00 , C07D401/12 , C07D249/12 , C07D403/12 , C07D405/12 , C07D413/12 , A61K45/06
CPC分类号： C07D401/12 , A61P35/00 , C07D249/12 , C07D403/12 , C07D405/12 , C07D413/12 , A61K45/06
摘要： The present invention provides triazolone compounds of general formula (I):
in which R1, R2, R3, R4, and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and prophylaxis of diseases, in particular hyperproliferative disorders, as a sole agent or in combination with other active ingredients.-
公开(公告)号：US10968216B2
公开(公告)日：2021-04-06
申请号：US16345178
申请日：2017-10-25
申请人： BAYER AKTIENGESELLSCHAFT , BAYER PHARMA AKTIENGESELLSCHAFT , THE BROAD INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE GENERAL HOSPITAL CORPORATION
发明人： Stefan Nikolaus Gradl , Duy Nguyen , Knut Eis , Judith Günther , Timo Stellfeld , Andreas Janzer , Sven Christian , Thomas Mueller , Sherif El Sheikh , Han Jie Zhou , Changjia Zhao , David B. Sykes , Steven James Ferrara , Kery Liu , Simon Anthony Herbert , Claudia Merz , Michael Niehues , Carl Friedrich Nising , Martina Schäfer , Katja Zimmermann , Jörg Knäblein , Kai Thede , Thomas Faupel
IPC分类号： C07D471/04 , A61P35/00 , C07D487/04 , C07D498/04 , C07D513/04 , C07D519/00 , C12N1/20 , C12P17/18
摘要： The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11787797B2
公开(公告)日：2023-10-17
申请号：US17161615
申请日：2021-01-28
申请人： BAYER AKTIENGESELLSCHAFT , BAYER PHARMA AKTIENGESELLSCHAFT , THE BROAD INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE GENERAL HOSPITAL CORPORATION
发明人： Stefan Nikolaus Gradl , Duy Nguyen , Knut Eis , Judith Günther , Timo Stellfeld , Andreas Janzer , Sven Christian , Thomas Mueller , Sherif El Sheikh , Han Jie Zhou , Changjia Zhao , David B. Sykes , Steven James Ferrara , Kery Liu , Simon Anthony Herbert , Claudia Merz , Michael Niehues , Carl Friedrich Nising , Martina Schäfer , Katja Zimmermann , Jörg Knäblein , Kai Thede , Thomas Faupel
IPC分类号： C07D471/04 , A61P35/00 , C07D487/04 , C07D498/04 , C07D513/04 , C07D519/00 , C12N1/20 , C12P17/18
CPC分类号： C07D471/04 , A61P35/00 , C07D487/04 , C07D498/04 , C07D513/04 , C07D519/00 , C12N1/20 , C12P17/18 , C12P17/182 , C12P17/188
摘要： The present invention provides triazolone compounds of general formula (I):
in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.-
公开(公告)号：US11130745B2
公开(公告)日：2021-09-28
申请号：US16996721
申请日：2020-08-18
申请人： BAYER AKTIENGESELLSCHAFT , BAYER PHARMA AKTIENGELLSCHAFT , THE BROAD INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE GENERAL HOSPITAL CORPORATION
发明人： Stefan Nikolaus Gradl , Duy Nguyen , Knut Eis , Judith Günther , Timo Stellfeld , Andreas Janzer , Sven Christian , Thomas Müller , Sherif El Sheikh , David B. Sykes , Steven James Ferrara , Michael Kröber , Claudia Merz , Michael Niehues , Martina Schäfer , Katja Zimmermann , Carl Friedrich Nising
IPC分类号： A61P35/00 , A61K45/06 , C07D401/12 , C07D249/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US10815215B2
公开(公告)日：2020-10-27
申请号：US16345168
申请日：2017-10-25
申请人： BAYER AKTIENGESELLSCHAFT , BAYER PHARMA AKTIENGELLSCHAFT , THE BROAD INSTITUTE, INC. , PRESIDENT AND FELLOWS OF HARVARD COLLEGE , THE GENERAL HOSPITAL CORPORATION
发明人： Stefan Nikolaus Gradl , Duy Nguyen , Knut Eis , Judith Günther , Timo Stellfeld , Andreas Janzer , Sven Christian , Thomas Müller , Sherif El Sheikh , Han Jie Zhou , Changjia Zhao , David B. Sykes , Steven James Ferrara , Kery Liu , Michael Kröber , Claudia Merz , Michael Niehues , Martina Schäfer , Katja Zimmermann , Carl Friedrich Nising
IPC分类号： C07D401/12 , A61P35/00 , C07D249/12 , C07D403/12 , C07D405/12 , C07D413/12 , A61K45/06
摘要： The present invention provides triazolone compounds of general formula (I): in which R1, R2, R3, R4 and R5 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20200087322A1
公开(公告)日：2020-03-19
申请号：US16301871
申请日：2017-05-17
发明人： Sarah Anna Liesa Johannes , Philipp Buchgraber , Ulrich Klar , Clara Christ , Kai Thede , Joachim Kuhnke , Manfred Moewes , Knut Eis , Amaury Fernandez-Montalvan , Nicolas Werbeck , Ursula Moenning , Philip Lienau , Ulrike Sack , Arne Scholz , Michael H. Serrano-Wu , Chris Lemke , David McKinney , Mark Fitzgerald , Christopher Nasveschuk , Kiel Lazarski , Steven James Ferrara , Laura Furst , Guo Wei , Patrick R. McCarren
IPC分类号： C07D498/16 , C07D487/16 , C07D498/22 , C07D498/06
摘要： The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11286263B2
公开(公告)日：2022-03-29
申请号：US16764563
申请日：2018-11-15
发明人： Steven James Ferrara , Michael H. Serrano-Wu , Chris Lemke , David McKinney , Mark Fitzgerald , Christopher Nasveschuk , Kiel Lazarski , Laura Furst , Guo Wei , Patrick Ryan McCarren , Kai Thede , Anne Mengel , Clara Christ , Joachim Kuhnke , Sarah Anna Liesa Johannes , Philipp Buchgraber , Ulrich Klar , Ulrike Sack , Stefan Kaulfuss , Amaury Ernesto Fernandez-Montalvan , Nicolas Werbeck , Ursula Mönning
IPC分类号： C07D487/14 , C07D403/14 , C07D498/14 , A61K31/4162 , A61P35/00
摘要： The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US11492358B1
公开(公告)日：2022-11-08
申请号：US17186820
申请日：2021-02-26
发明人： Sarah Anna Liesa Johannes , Philipp Buchgraber , Ulrich Klar , Clara Christ , Kai Thede , Joachim Kuhnke , Manfred Moewes , Knut Eis , Amaury Ernesto Fernandez-Montalvan , Nicolas Werbeck , Ursula Mönning , Philip Lienau , Ulrike Sack , Arne Scholz , Michael H. Serrano-Wu , Christopher Lemke , David McKinney , Mark Fitzgerald , Christopher Nasveschuk , Kiel Lazarski , Steven James Ferrara , Laura Furst , Guo Wei , Patrick Ryan McCarren
IPC分类号： C07D498/16 , C07D498/06 , C07D498/22 , C07D487/16
摘要： The present invention relates to macrocyclic indole derivatives of general formula (I) in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20210277022A1
公开(公告)日：2021-09-09
申请号：US16764675
申请日：2018-11-15
发明人： Kai Thede , Anne Mengel , Clara Christ , Joachim Kuhnke , Sarah Anna Liesa Johannes , Philipp Buchgraber , Ulrich Klar , Ulrike Sack , Stefan Kaulfuss , Amaury Ernesto Fernandez-Montalvan , Nicolas Werbeck , Ursula Mönning , Katrin Nowak-Reppel , Jeremie Xavier Mortier , Patrick Ryan McCarren , Michael H. Serrano-Wu , Christopher Lemke , David McKinney , Mark Fitzgerald , Christopher Nasveschuk , Kiel Lazarski , Steven James Ferrara , Laura Furst , Guo Wei , Rebecca Ann Flarvey , Daniel Payne , Thomas Pesnot , Craig Wilson
IPC分类号： C07D498/14 , C07D487/14 , A61K45/06
摘要： The present invention relates to macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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公开(公告)号：US20210253598A1
公开(公告)日：2021-08-19
申请号：US16764560
申请日：2018-11-15
发明人： Kai Thede , Anne Mengel , Clara Christ , Joachim Kuhnke , Sarah Anna Liesa Johannes , Philipp Buchgraber , Ulrich Klar , Ulrike Sack , Stefan Kaulfuss , Amaury Ernesto Fernandez-Montalvan , Nicolas Werbeck , Ursula Mönning , Steven James Ferrara , Michael H. Serrano-Wu , Christopher Lemke , David McKinney , Mark Fitzgerald , Christopher Nasveschuk , Kiel Lazarski , Laura Furst , Guo Wei , Patrick Ryan MacCarren , Rebecca Ann Harvey , Craig Wilson
IPC分类号： C07D498/14 , A61K45/06 , C07D498/22 , A61K31/437 , A61K31/4162 , A61K31/4985 , C07D487/14 , A61K31/424 , A61P35/00 , A61P35/02
摘要： The present invention relates to aryl annulated macrocyclic indole derivatives of general formula (I): in which R1, R2, R3, R4, R5, R6, A and L are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds, and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative disorders, as a sole agent or in combination with other active ingredients.
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