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公开(公告)号：US10472348B2
公开(公告)日：2019-11-12
申请号：US15969222
申请日：2018-05-02
发明人： Marie-Pierre Collin , Peter Kolkhof , Thomas Neubauer , Chantal Fürstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Anja Buchmüller , Hanna Tinel , Karoline Dröbner , Thomas Mondritzki , Heiko Schirmer , Axel Kretschmer , Carsten Schmeck , Pierre Wasnaire , Hana Cernecka
IPC分类号： A61K31/4439 , C07D401/14 , A61K45/06 , A61P9/10 , A61P3/10 , A61P13/12 , A61P9/04
摘要： The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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![Substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-A]pyridine-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-C][1,2,4]triazol-3-ones, and use thereof](/abs-image/US/2020/07/28/US10722501B2/abs.jpg.150x150.jpg)
公开(公告)号：US10722501B2
公开(公告)日：2020-07-28
申请号：US16300480
申请日：2017-05-08
发明人： Nicole Biber , Damian Brockschnieder , Kersten Matthias Gericke , Florian Kölling , Klemens Lustig , Jörg Meding , Heinrich Meier , Thomas Neubauer , Martina Schäfer , Andreas Timmermann , Dmitry Zubov , Carsten Terjung , Niels Lindner , Volker Badock , Dieter Moosmayer , Hideki Miyatake Ondozabal , Stephen Moore , Alexander Schulz
IPC分类号： A61K31/437 , A61K31/506 , C07D471/04 , A61K31/4375 , A61K31/4709 , A61K31/497 , C07D519/00 , A61K45/06 , A61K31/444 , A61P11/00 , A61P29/00
摘要： The present application relates to novel substituted 5,6,7,8-tetrahydro[1,2,4]triazolo[4,3-a]pyridin-3(2H)-ones and 2,5,6,7-tetrahydro-3H-pyrrolo[2,1-c][1,2,4]triazol-3-ones of formula (I), to processes for preparation thereof, to the use thereof, alone or in combinations, for treatment and/or prophylaxis of diseases, and to the use thereof for production of medicaments for treatment and/or prophylaxis of diseases, especially for treatment and/or prophylaxis of lung inflammation disorders.
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公开(公告)号：US11667675B2
公开(公告)日：2023-06-06
申请号：US17138447
申请日：2020-12-30
发明人： Donald Bierer , Ingo Flamme , Dmitry Zubov , Thomas Neubauer , Adrian Tersteegen , Cathleen Juhl , Marie Glatz , Jan Dreher , Simon Holton , Carsten Terjung , Lars Baumann , Thorsten Poethko , Jiancheng Xiong , Yibo Qiu
摘要： The present invention relates to novel Mannose-binding lectin (MBL)-associated serine protease (MASP) inhibitory compounds, as well as analogues and derivatives thereof, to processes for the preparation thereof, to the use thereof alone or in combinations for treatment and/or prevention of diseases and to the use thereof for production of medicaments for treatment and/or prevention of diseases, especially for treatment and/or prevention of renal and cardiovascular disorders and of ischemia reperfusion injuries.
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公开(公告)号：US11298367B2
公开(公告)日：2022-04-12
申请号：US16758742
申请日：2018-10-17
发明人： Marie-Pierre Collin-Kroepelin , Peter Kolkhof , Thomas Neubauer , Chantal Fuerstner , Elisabeth Pook , Matthias Beat Wittwer , Carsten Schmeck , Pierre Wasnaire , Heiko Schirmer , Hana Cernecka , Karoline Droebner , Hanna Tinel , Anja Buchmueller , Thomas Mondritzki , Axel Kretschmer , Klemens Lustig , Robert Fricke , Guillaume Levilain , Ursula Krenz , Norbert Witowski
IPC分类号： A61K31/675 , A61P13/12 , A61K45/06 , C07F9/6558
摘要： The present invention relates to prodrugs of 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[3-(trifluoromethyl)-pyridin-2-yl ]-1H-1,2,4-triazole-5-carboxamide, 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-[2-(trifluoromethyl)-phenyl]-1H-1,2,4-triazole-5-carboxamide and 3-({3-(4-chlorophenyl)-5-oxo-4-[(2S)-3,3,3-trifluoro-2-hydroxypropyl ]-4,5-dihydro-1H-1,2,4-triazol-1-yl}methyl)-1-(3-chloropyridin-2-yl)-1H-1,2,4-triazole-5-carboxamide, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US11173151B2
公开(公告)日：2021-11-16
申请号：US16756623
申请日：2018-10-17
发明人： Marie-Pierre Collin-Kroepelin , Peter Kolkhof , Thomas Neubauer , Chantal Fuerstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Hanna Tinel , Niels Lindner , Heiko Schirmer
IPC分类号： A61K31/4439 , A61K31/4188 , A61K31/4196 , A61K31/496 , A61K31/5377 , A61K31/541 , A61K31/551 , A61K45/06 , C07D401/14 , C07D403/06 , C07D403/14 , C07D405/14 , C07D409/14 , C07D413/14 , C07D417/14 , C07D487/10
摘要： The present invention relates to novel substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US10525041B2
公开(公告)日：2020-01-07
申请号：US16098255
申请日：2017-05-02
发明人： Thomas Neubauer , Marie-Pierre Collin-Kröpelin , Peter Kolkhof , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Carsten Schmeck , Pierre Wasnaire , Heiko Schirmer
IPC分类号： A61K31/4196 , C07D403/06 , A61P9/10 , A61P13/12 , A61K31/4439 , A61K45/06 , C07D401/14 , C07D405/14 , C07D249/12
摘要： The present invention relates to novel 5-(fluoroalkyl)-1-aryl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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![Substituted [1,2,4]triazolo[4,3-A]pyrazines as prolyl endopeptidase inhibitors](/abs-image/US/2022/05/24/US11337973B2/abs.jpg.150x150.jpg)
公开(公告)号：US11337973B2
公开(公告)日：2022-05-24
申请号：US16761713
申请日：2018-10-31
发明人： Nicole Biber , Damian Brockschnieder , Florian Kölling , Jörg Meding , Hideki Miyatake Ondozabal , Thomas Neubauer , Martina Schäfer , Dmitry Zubov , Carsten Terjung
IPC分类号： A61K31/4985 , C07D487/04 , A61P11/00 , A61K45/06
摘要： The invention relates to prolyl endopeptidase (PREP) inhibitors of formula (I) which contain a condensed 2,4-dihydro-3H-1,2,4-triazol-3-one ring system, methods for producing same, the use thereof alone or in combinations for treating and/or preventing diseases, and the use thereof for producing drugs for treating and/or preventing diseases, in particular for treating and/or preventing inflammatory lung diseases (COPD).
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公开(公告)号：US11331314B2
公开(公告)日：2022-05-17
申请号：US16758802
申请日：2018-10-17
发明人： Marie-Pierre Collin-Kroepelin , Peter Kolkhof , Thomas Neubauer , Chantal Fuerstner , Elisabeth Pook , Hanna Tinel , Carsten Schmeck , Pierre Wasnaire , Heiko Schirmer , Klemens Lustig
IPC分类号： A61K31/496 , A61P9/12 , A61K31/4196 , A61K31/422 , A61K31/454 , A61K31/541 , A61K31/55 , A61K45/06 , C07D403/06 , C07D403/14 , C07D413/14 , C07D417/14 , C07D487/10
摘要： The present invention relates to novel amine substituted 1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US11091463B2
公开(公告)日：2021-08-17
申请号：US16579341
申请日：2019-09-23
发明人： Marie-Pierre Collin , Peter Kolkhof , Thomas Neubauer , Chantal Fuerstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Anja Buchmueller , Hanna Tinel , Karoline Droebner , Thomas Mondritzki , Heiko Schirmer , Axel Kretschmer , Carsten Schmeck , Pierre Wasnaire , Hana Cernecka
IPC分类号： A61K31/4439 , C07D401/14 , A61K45/06 , A61P9/10 , A61P3/10 , A61P13/12 , A61P9/04
摘要： The present invention relates to novel 5-(carboxamide)-1-pyridinyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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公开(公告)号：US10815205B2
公开(公告)日：2020-10-27
申请号：US16098266
申请日：2017-05-02
发明人： Marie-Pierre Collin-Kröpelin , Peter Kolkhof , Thomas Neubauer , Chantal Fürstner , Elisabeth Pook , Matthias Beat Wittwer , Klemens Lustig , Anja Buchmüller , Hanna Tinel , Karoline Dröbner , Thomas Mondritzki , Heiko Schirmer , Axel Kretschmer , Carsten Schmeck , Pierre Wasnaire , Hana Cernecka
IPC分类号： C07D249/14 , C07D403/06 , A61P9/00 , A61P13/12 , A61K31/4196 , A61K45/06 , C07D249/12
摘要： The present invention relates to novel 5-(carboxamide)-1-phenyl-1,2,4-triazole derivatives, to processes for the preparation of such compounds, to pharmaceutical compositions containing such compounds, and to the use of such compounds or compositions for the treatment and/or prevention of diseases, in particular for the treatment and/or prevention of renal and cardiovascular diseases.
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