公开(公告)号：US10772893B2

公开(公告)日：2020-09-15

申请号：US15974536

申请日：2018-05-08

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Lars Wortmann ,  Ulrich Lücking ,  Julien Lefranc ,  Hans Briem ,  Marcus Koppitz ,  Knut Eis ,  Franz Von Nussbaum ,  Benjamin Bader ,  Antje Margret Wengner ,  Gerhard Siemeister ,  Wilhelm Bone ,  Philip Lienau ,  Joanna Grudzinska-Goebel ,  Dieter Moosmayer ,  Uwe Eberspächer ,  Hans Schick

IPC分类号： C07D471/04 ,  C07D413/14 ,  A61K31/541 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/55 ,  A61K31/675 ,  A61K45/06 ,  C07D491/22 ,  C07D519/00 ,  C07F9/6561

摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (Ib), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.

公开(公告)号：US09670161B2

公开(公告)日：2017-06-06

申请号：US14436968

申请日：2013-10-15

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Ulrich Lücking ,  Niels Böhnke ,  Arne Scholz ,  Philip Lienau ,  Gerhard Siemeister ,  Ulf Bömer ,  Dirk Kosemund ,  Rolf Bohlmann ,  Ludwig Zorn

IPC分类号： C07D213/72 ,  C07D213/74 ,  C07D405/14 ,  A61K31/444

CPC分类号： C07D213/74 ,  A61K31/444 ,  C07D405/14

摘要： The present invention relates to 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

公开(公告)号：US09499492B2

公开(公告)日：2016-11-22

申请号：US14443180

申请日：2013-11-11

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Ulrich Lücking ,  Dirk Kosemund ,  Rolf Bohlmann ,  Arne Scholz ,  Philip Lienau ,  Gerhard Siemeister ,  Ulf Bömer

IPC分类号： C07D239/42 ,  A61K31/505 ,  A61K31/506 ,  C07D405/04

CPC分类号： C07D239/42 ,  A61K31/505 ,  A61K31/506 ,  C07D405/04

摘要： The present invention relates to 4-(ortho)-fluorophenyl-5-fluoropyrimidin-2-yl amine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

摘要翻译： 本发明涉及含有本文所述和定义的通式（I）的亚磺酰亚胺基的4-（邻位） - 氟苯基-5-氟嘧啶-2-基胺衍生物及其制备方法及其用于治疗和 /或预防疾病，特别是高增殖性疾病和/或病毒诱导的传染病和/或心血管疾病的疾病。 本发明还涉及可用于制备所述通式（I）化合物的中间体化合物。

公开(公告)号：US09993484B2

公开(公告)日：2018-06-12

申请号：US15501079

申请日：2015-08-03

申请人： BAYER PHARMA AKTIENGESELLSCHAFT ,  Christine Wedler

发明人： Lars Wortmann ,  Ulrich Lücking ,  Julien LeFranc ,  Hans Briem ,  Marcus Koppitz ,  Knut Eis ,  Franz Von Nussbaum ,  Benjamin Bader ,  Antje Margret Wengner ,  Gerhard Siemeister ,  Wilhelm Bone ,  Philip Lienau ,  Joanna Grudzinska-Goebel ,  Dieter Moosmayer ,  Uwe Eberspächer ,  Hans Schick

IPC分类号： C07D471/04 ,  C07D413/04 ,  C07D295/02 ,  C07D403/14 ,  A61K31/5377 ,  A61K31/4375 ,  A61K31/4025 ,  A61K31/4155 ,  A61K31/541 ,  A61K31/5386 ,  A61K31/55 ,  A61K31/675 ,  A61K45/06 ,  C07D491/22 ,  C07D519/00 ,  C07F9/6561

CPC分类号： A61K31/541 ,  A61K31/5377 ,  A61K31/5386 ,  A61K31/55 ,  A61K31/675 ,  A61K45/06 ,  C07D471/04 ,  C07D491/22 ,  C07D519/00 ,  C07F9/6561

摘要： The present invention relates to substituted 2-(morpholin-4-yl)-1,7-naphthyridine compounds of general formula (I) or (1b), to methods of preparing said compounds, to intermediate compounds useful for preparing said compounds, to pharmaceutical compositions and combinations comprising said compounds and to the use of said compounds for manufacturing a pharmaceutical composition for the treatment or prophylaxis of a disease, in particular of a hyperproliferative disease as a sole agent or in combination with other active ingredients.

公开(公告)号：US09884849B2

公开(公告)日：2018-02-06

申请号：US15519076

申请日：2015-10-14

申请人： Bayer Pharma Aktiengesellschaft

发明人： Dirk Kosemund ,  Ulrich Lücking ,  Gerhard Siemeister ,  Arne Scholz ,  Philip Lienau

IPC分类号： C07D405/04 ,  A61K31/506 ,  C07D405/10 ,  C07D239/42

CPC分类号： C07D405/10 ,  A61K31/506 ,  C07D239/42 ,  C07D405/04

摘要： The present invention relates to fluorinated benzofuranyl-pyrimidine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

公开(公告)号：US09856242B2

公开(公告)日：2018-01-02

申请号：US15125659

申请日：2015-03-12

申请人： Bayer Pharma Aktiengesellschaft

发明人： Dirk Kosemund ,  Ulrich Lücking ,  Arne Scholz ,  Gerhard Siemeister ,  Philip Lienau

IPC分类号： A61K31/444 ,  C07D405/14

CPC分类号： C07D405/14 ,  A61K31/444

摘要： The present invention relates to 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfone group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

公开(公告)号：US09650340B2

公开(公告)日：2017-05-16

申请号：US14443279

申请日：2013-11-12

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Ulrich Lücking ,  Niels Böhnke ,  Arne Scholz ,  Philip Lienau ,  Gerhard Siemeister ,  Ulf Bömer ,  Dirk Kosemund ,  Rolf Bohlmann ,  Ludwig Zorn

IPC分类号： C07D405/14 ,  C07D213/72 ,  C07D401/12 ,  A61K31/444

CPC分类号： A61K31/444 ,  C07D213/72 ,  C07D401/12

摘要： The present invention relates to 5-fluoro-N-(pyridin-2-yl)pyridin-2-amine derivatives containing a sulfoximine group of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

公开(公告)号：US20150259300A1

公开(公告)日：2015-09-17

申请号：US14436966

申请日：2013-10-15

申请人： BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Ulrich Lücking ,  Rolf Bohlmann ,  Dirk Kosemund ,  Arne Scholz ,  Philip Lienau ,  Gerhard Siemeister ,  Ulf Bömer

IPC分类号： C07D239/42 ,  C07D239/26 ,  A61K31/505

CPC分类号： C07D239/42 ,  A61K31/505 ,  C07D239/26

摘要： The present invention relates to 4-(ortho)-fluorophenyl-5-fluoropyrimidin-2-yl amine derivatives of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

摘要翻译： 本发明涉及本文所述和定义的通式（I）的4-（邻） - 氟苯基-5-氟嘧啶-2-基胺衍生物及其制备方法及其用于治疗和/或预防 疾病，特别是高增殖性疾病和/或病毒诱导的传染病和/或心血管疾病。 本发明还涉及可用于制备所述通式（I）化合物的中间体化合物。

公开(公告)号：US11254690B2

公开(公告)日：2022-02-22

申请号：US16498662

申请日：2018-03-22

申请人： BAYER AKTIENGESELLSCHAFT ,  BAYER PHARMA AKTIENGESELLSCHAFT

发明人： Ulrich Lücking ,  Daniel Hog ,  Clara Christ ,  Ulrike Sack ,  Franziska Siegel ,  Philip Lienau ,  Nicolas Werbeck

IPC分类号： C07D498/18 ,  A61P35/00 ,  C07D498/08

摘要： The present invention relates to novel modified macrocyclic compounds with improved tolerability of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).

公开(公告)号：US11242356B2

公开(公告)日：2022-02-08

申请号：US16497578

申请日：2018-03-22

申请人： Bayer Aktiengesellschaft ,  Bayer Pharma Aktiengesellschaft

发明人： Ulrich Lücking ,  Daniel Hog ,  Clara Christ ,  Ulrike Sack ,  Franziska Siegel ,  Philip Lienau ,  Nicolas Werbeck

IPC分类号： C07D498/18 ,  C07D213/61 ,  C07D239/30 ,  C07D498/08

摘要： The present invention relates to novel modified macrocyclic compounds with improved tolerability of general formula (I) as described and defined herein, and methods for their preparation, their use for the treatment and/or prophylaxis of disorders, in particular of hyper-proliferative disorders and/or virally induced infectious diseases and/or of cardiovascular diseases. The invention further relates to intermediate compounds useful in the preparation of said compounds of general formula (I).