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1.发明申请公开(公告)号：US20220341925A1
公开(公告)日：2022-10-27
申请号：US17434408
申请日：2021-02-07
发明人： Yue LI , Wenliang YAO , Nan ZHAO , Yongjia GAO , Bolin FAN , Le GU , Hui LIAO , Yingying ZHAO
IPC分类号： G01N33/543 , G01N21/76
摘要： The present disclosure relates to a digital microfluidic chemiluminescence detection chip, a detection method and a detection device. The digital microfluidic chemiluminescence detection chip includes a first baseplate and a second baseplate disposed oppositely. A cavity formed by the first and second baseplate includes a mixing and incubating area for combining an antigen, a magnetic particle antibody and an antibody, a luminescence detection area for chemiluminescence and detecting an optical signal, and a communication path for communicating the mixing and incubating area and the luminescence detection area. The first baseplate is provided with a drive array for driving sample solution to move and an optical sensing array for acquiring a luminescence signal of the sample solution. The drive array corresponds to positions of the mixing and incubating area, the luminescence detection area and the communication path. The optical sensing array corresponds to a position of the luminescence detection area.
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公开(公告)号：US20220023865A1
公开(公告)日：2022-01-27
申请号：US16631780
申请日：2019-05-13
发明人： Le GU , Peizhi CAI , Fengchun PANG , Yue GENG , Yingying ZHAO , Haochen CUI , Yuelei XIAO , Hui LIAO , Wenliang YAO , Nan ZHAO
摘要： A microfluidic device and a detection method for the microfluidic device are provided. The microfluidic device includes a driving substrate configured to drive a movement of a droplet; and a position detector configured to detect a position of the droplet on the driving substrate.
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公开(公告)号：US20210268499A1
公开(公告)日：2021-09-02
申请号：US17186186
申请日：2021-02-26
发明人： Hui LIAO , Yingying ZHAO , Bolin FAN , Wenliang YAO , Nan ZHAO , Le GU , Yongjia GAO
IPC分类号： B01L3/00 , G01N33/577 , G01N27/22
摘要： The present disclosure discloses a microfluidic structure, a microfluidic chip and a detection method. The microfluidic structure includes: a first base substrate and a second base substrate opposite to each other, an antibody area located between the first base substrate and the second base substrate and storing an enzyme-labeled first antibody, a cleaning area storing cleaning liquid, a signal substrate area storing a signal substrate solution and a detection area with a second antibody and an ion sensitive film fixed thereon, wherein all channel areas from the antibody area, the cleaning area and the signal substrate area to the detection area each have a driving electrode structure driving liquid drops to move; and the detection area has a thin film transistor connected with the ion sensitive film.
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公开(公告)号：US20220126287A1
公开(公告)日：2022-04-28
申请号：US17271297
申请日：2020-05-13
发明人： Yue LI , Wenliang YAO , Nan ZHAO , Yongjia GAO , Le GU , Hui LIAO , Bolin FAN , Yingying ZHAO
摘要： Provided is a micro-fluidic chip, including a first substrate and a second substrate opposite to each other. A liquid storage cavity is formed between the first substrate and the second substrate, and a liquid inlet hole penetrating through the first substrate in a thickness direction is formed in the first substrate. The first substrate includes a first electrode layer and a hydrophobic layer that are sequentially disposed in the thickness direction of the first substrate, and the first electrode layer is on a surface of the hydrophobic layer away from the second substrate. The second substrate includes an adjustment layer and a second electrode layer that are sequentially disposed in a thickness direction of the second substrate, and the second electrode layer is on a surface of the adjustment layer away from the first substrate. A micro-fluidic system and a control method of the micro-fluidic chip are also provided.
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公开(公告)号：US20220395832A1
公开(公告)日：2022-12-15
申请号：US17599999
申请日：2020-12-25
发明人： Bolin FAN , Le GU , Yingying ZHAO , Wenliang YAO , Yongjia GAO , Qiuxu WEI
IPC分类号： B01L3/00
摘要： The present disclosure provides a substrate for driving droplets, a manufacturing method thereof, and a microfluidic device. The substrate includes a first base substrate a plurality of leads on the first base substrate a plurality of driving electrodes on a side of the plurality of leads away from the first base substrate and a shielding electrode on the side of the plurality of leads away from the first base substrate and grounded. Each of the plurality of leads is electrically connected to at least one of the plurality of driving electrodes, an orthographic projection of the shielding electrode on the first base substrate and an orthographic projection of at least one of the plurality of leads on the first base substrate at least partially overlap, and the shielding electrode is electrically insulated from the plurality of driving electrodes.
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6.发明申请公开(公告)号：US20220193669A1
公开(公告)日：2022-06-23
申请号：US17600090
申请日：2021-02-26
发明人： Yongjia GAO , Yingying ZHAO , Hui LIAO , Wenliang YAO , Le GU , Bolin FAN , Yue LI
摘要： Provided are a temperature control system, a detection system and a temperature control method for a micro-fluidic chip. The temperature control system includes a circuit structure in a functional layer of the micro-fluidic chip, corresponding to a reaction zone of the micro-fluidic chip, and including at least two thermistors and an input port and an output port, wherein the input port and the output port are electrically coupled through the thermistors to form an application circuit; and a controller electrically coupled to each port and configured to select a first input port and a first output port, such that the circuit structure is configured to form a first application circuit as a heating device, and to select a second input port and a second output port, such that the circuit structure is configured to form a second application circuit as a temperature sensor.
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公开(公告)号：US20220314217A1
公开(公告)日：2022-10-06
申请号：US17600294
申请日：2021-01-29
发明人： Le GU , Yingying ZHAO , Wenliang YAO , Bolin FAN , Yongjia GAO , Qiuxu WEI
摘要： The present disclosure provides a microfluidic chip, and belongs to the field of biological detection technology. The microfluidic chip is divided into a middle region and a peripheral region surrounding the middle region; the middle region includes a liquid storage region and a detection region; the microfluidic chip includes a first substrate and a second substrate opposite to each other; the first substrate includes a first base plate and a first electrode layer; the second substrate includes a second base plate and a second electrode layer; wherein a liquid storage tank and a liquid inlet are on a side of the first base plate proximal to the second substrate, the liquid inlet penetrates through a bottom of the liquid storage tank; the liquid storage tank and the liquid inlet are both in the liquid storage region.
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8.发明申请公开(公告)号：US20220314216A1
公开(公告)日：2022-10-06
申请号：US17419846
申请日：2020-09-29
发明人： Bolin FAN , Yingying ZHAO , Le GU , Wenliang YAO , Hui LIAO , Yongjia GAO , Qiuxu WEI
摘要： A micro-fluidic chip is provided. The micro-fluidic chip includes: a first base substrate; a first electrode on the first base substrate and electrically coupled to a wire at a driving end; a second electrode on a side of the first electrode away from the first base substrate and spaced apart and electrically insulated from the first electrode, the second electrode including a plurality of sub-blocks of the second electrode, and an orthographic projection of the second electrode on the first base substrate being at least partially overlapped with an orthographic projection of the first electrode on the first base substrate; and voltage-dividing resistors coupled to the plurality of sub-blocks of the second electrode in one-to-one correspondence and electrically coupled to a ground wire.
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公开(公告)号：US20220226816A1
公开(公告)日：2022-07-21
申请号：US17489920
申请日：2021-09-30
发明人： Qiuxu WEI , Wenliang YAO , Yingying ZHAO , Le GU , Bolin FAN , Yongjia GAO
IPC分类号： B01L3/00
摘要： The disclosure provides a micro-fluidic chip, and belongs to the field of chip technology. The microfluidic chip provided in the present disclosure includes a plurality of microfluidic units, each microfluidic unit includes an operation region and a transition region located on at least one side of the operation region, the transition regions at adjacent side of two adjacent microfluidic units are disposed opposite to each other. Each microfluidic unit includes: a first substrate; a first electrode layer disposed on the first substrate, the first electrode layer including a plurality of first sub-electrodes located in the operation region and at least one second sub-electrode located in the transition region, and the at least one second sub-electrode configured to drive a droplet to move from one of the plurality of microfluidic units to an adjacent microfluidic unit.
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公开(公告)号：US20220403306A1
公开(公告)日：2022-12-22
申请号：US17598928
申请日：2020-12-25
发明人： Bolin FAN , Le GU , Yingying ZHAO , Wenliang YAO , Yongjia GAO , Qiuxu WEI
摘要： Disclosed are a substrate for a microfluidic device, a microfluidic device, a driving method of the microfluidic device, and a method of manufacturing a substrate for the microfluidic device. The substrate includes: a first base substrate; a first electrode layer on the first base substrate, the first electrode layer including a plurality of drive electrodes. The plurality of drive electrodes define at least one flow channel and at least one functional area in the first substrate, the at least one functional area includes a reagent area, the at least one flow channel includes a reagent area flow channel, the reagent area includes a reagent area liquid storage portion and a droplet shape changing portion, the droplet shape changing portion is adjacent to the reagent area flow channel, and the reagent liquid storage portion is on a side of the droplet shape changing portion away from the reagent area flow channel.
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