公开(公告)号：US12150992B2

公开(公告)日：2024-11-26

申请号：US17492060

申请日：2021-10-01

Applicant: BEIJING INSTITUTE OF TECHNOLOGY

Inventor： Lan Jiang ,  Yunlong Ma ,  Jie Hu

IPC: A61L27/54 ,  A61K41/00 ,  A61L27/06 ,  A61P35/00 ,  B82Y5/00 ,  B82Y30/00 ,  B82Y40/00 ,  C23C18/42

Abstract: The present disclosure relates to a multifunctional therapeutic biological material and preparation method thereof. The process steps of the preparation method are as follows: (1) preparing various three-dimensional micro/nano composite structure on the surface of a biomedical material by using femtosecond laser double pulses; (2) further preparing a nano-flower structure on the three-dimensional micro/nano composite structure by using hydrothermal synthesis method to construct a heterogeneous structure consisting of the three-dimensional micro/nano composite structure and the nano-flower structure; (3) putting the prepared heterogeneous structure into a mixed solution containing gold ions and platinum ions, and by using ultraviolet light reduction method, reducing in situ into gold-platinum bimetallic nanoparticles on the heterogeneous structure to obtain the multifunctional therapeutic biological material. The multifunctional therapeutic biological material provided by the present disclosure has excellent light-to-heat conversion characteristics, and it can promote bone regeneration, and has functions of tumor treatment and anti-bacterial infection.