-
公开(公告)号：US20240281625A1
公开(公告)日：2024-08-22
申请号：US18651099
申请日：2024-04-30
Applicant: BGI SHENZHEN
Inventor： Wenwei Zhang , Mei Li , Weimao Wang , Yuxiang Li , Xun Xu
CPC classification number: G06K7/087 , G01N33/54326 , G06T5/77 , G06T7/0002 , G06T7/13 , G06T7/62 , G06T7/73 , G06T2207/10024 , G06T2207/10064 , G06T2207/20081 , G06T2207/20084 , G06T2207/30204
Abstract: Provided are a magnetic bead-based detection method, a storage medium, and a detection device. The detection method includes: collecting a white light image of a to-be-detected solution, in which the to-be-detected solution is mixed with a to-be-detected sample and magnetic beads with a capture agent (S1); determining magnetic stripe regions in the white light image, and determining first magnetic bead regions based on the magnetic stripe regions (S2); selecting, by using a first neural network, second magnetic bead regions containing magnetic beads from the first magnetic bead regions, and obtaining a marker position of each of the magnetic beads (S3); and obtaining, by using a second neural network and based on each of the second magnetic bead regions, codes at code bits of a corresponding magnetic bead, and obtaining corresponding code information based on the codes of the code bits and the marker position of the magnetic bead (S4).
-
公开(公告)号：US20250066747A1
公开(公告)日：2025-02-27
申请号：US18723588
申请日：2021-12-31
Applicant: BGI Shenzhen
Inventor： Xun Xu , Fei Guo , Qiaoxia Hu , Denghui Li , Junyi Chen , Lele Wang , Ziyu Zhao , Zhouxiang Ji , Tao Zeng , Ou Wang , Yuxiang Li , Yuliang Dong , Wenwei Zhang
IPC: C12N9/14 , C12Q1/6869
Abstract: Provided is helicase BCH1X, which comprises an amino acid sequence represented by SEQ ID NO: 1 or 2. Further provided are a complex structure comprising helicase BCH1X and a binding moiety used for binding to a polynucleotide, and a use thereof in the control and characterization of a polynucleotide and in single molecule nanopore sequencing.
-
公开(公告)号：US20250066748A1
公开(公告)日：2025-02-27
申请号：US18723633
申请日：2021-12-31
Applicant: BGI Shenzhen
Inventor： Lele Wang , Tao Zeng , Zhenjun Liu , Junyi Chen , Ziyu Zhao , Denghui Li , Fei Guo , Zhouxiang Ji , Ou Wang , Yuxiang Li , Yuliang Dong , Wenwei Zhang , Xun Xu
IPC: C12N9/14 , C12N15/70 , C12Q1/34 , C12Q1/6869
Abstract: The present invention provides a helicase BCH2X, comprising an amino acid sequence represented by any one of SEQ ID NOs: 1-3. The present invention also provides a complex structure comprising the helicase BCH2X and a binding moiety for binding polynucleotides. The present invention also provides a use of the helicase BCH2X or the complex structure comprising same in the control and characterization of polynucleotides and single-molecule nanopore sequencing.
-
公开(公告)号：US12277468B2
公开(公告)日：2025-04-15
申请号：US18651099
申请日：2024-04-30
Applicant: BGI SHENZHEN
Inventor： Wenwei Zhang , Mei Li , Weimao Wang , Yuxiang Li , Xun Xu
Abstract: Provided are a magnetic bead-based detection method, a storage medium, and a detection device. The detection method includes: collecting a white light image of a to-be-detected solution, in which the to-be-detected solution is mixed with a to-be-detected sample and magnetic beads with a capture agent (S1); determining magnetic stripe regions in the white light image, and determining first magnetic bead regions based on the magnetic stripe regions (S2); selecting, by using a first neural network, second magnetic bead regions containing magnetic beads from the first magnetic bead regions, and obtaining a marker position of each of the magnetic beads (S3); and obtaining, by using a second neural network and based on each of the second magnetic bead regions, codes at code bits of a corresponding magnetic bead, and obtaining corresponding code information based on the codes of the code bits and the marker position of the magnetic bead (S4).
-
-
-
Search Results
4
records
(took 0.009 seconds)
