-
公开(公告)号：US20210206794A1
公开(公告)日：2021-07-08
申请号：US17208831
申请日：2021-03-22
Applicant: MGI Tech Co., Ltd. , BGI Shenzhen
Inventor： Handong Li , Snezana Drmanac , Radoje Drmanac , Xun Xu , Lingling Peng , Scott Gablenz
IPC: C07H15/04 , C07H19/10 , C07H19/20 , C12Q1/6869 , C07H21/04
Abstract: Reversibly blocked nucleoside analogues and methods of using such nucleoside analogues for sequencing of nucleic acids are provided.
-
公开(公告)号：US10988501B2
公开(公告)日：2021-04-27
申请号：US16094845
申请日：2017-04-21
Applicant: Complete Genomics, Inc. , BGI Shenzhen
Inventor： Handong Li , Snezana Drmanac , Radoje Drmanac , Xun Xu , Lingling Peng , Scott Gablenz
IPC: C07H19/10 , C07H19/20 , C07H15/04 , C12Q1/6869 , C07H21/04
Abstract: Reversibly blocked nucleoside analogues and methods of using such nucleoside analogues for sequencing of nucleic acids are provided.
-
公开(公告)号：US12277468B2
公开(公告)日：2025-04-15
申请号：US18651099
申请日：2024-04-30
Applicant: BGI SHENZHEN
Inventor： Wenwei Zhang , Mei Li , Weimao Wang , Yuxiang Li , Xun Xu
Abstract: Provided are a magnetic bead-based detection method, a storage medium, and a detection device. The detection method includes: collecting a white light image of a to-be-detected solution, in which the to-be-detected solution is mixed with a to-be-detected sample and magnetic beads with a capture agent (S1); determining magnetic stripe regions in the white light image, and determining first magnetic bead regions based on the magnetic stripe regions (S2); selecting, by using a first neural network, second magnetic bead regions containing magnetic beads from the first magnetic bead regions, and obtaining a marker position of each of the magnetic beads (S3); and obtaining, by using a second neural network and based on each of the second magnetic bead regions, codes at code bits of a corresponding magnetic bead, and obtaining corresponding code information based on the codes of the code bits and the marker position of the magnetic bead (S4).
-
公开(公告)号：US12247198B2
公开(公告)日：2025-03-11
申请号：US17311697
申请日：2018-12-14
Applicant: BGI SHENZHEN
Inventor： Xin Fang , Xiaoluo Huang , Yue Shen , Xun Xu
Abstract: A nucleic acid synthesis device and a nucleic acid purification device, uses thereof, and a nucleic acid synthesis method and a nucleic acid purification method. The nucleic acid synthesis device includes a solid support, and the solid support includes a controlled pore glass (CPG), the CPG is an unmodified and bare CPG, a surface of the CPG has a hydroxyl group, and the hydroxyl group is attachable, though a covalent bond, to a phosphoramidite-protected nucleotide monomer or multimer for synthesis of nucleic acid. The nucleic acid synthesis device of the present disclosure can be used for not only synthesis of an oligonucleotide primer, but also for purification of enzymatic digestion and PCR product by using the oligonucleotide primer immobilized on the CPG, and has advantages of simple structure, small volume, light weight, high efficiency, low costs, and diversified functions.
-
公开(公告)号：US20250136974A1
公开(公告)日：2025-05-01
申请号：US18725483
申请日：2021-12-31
Applicant: BGI Shenzhen
Inventor： Ou Wang , Xiao Shi , Xun Xu , Wenwei Zhang , Fei Guo , Siyu Bao , Yuliang Dong , Tao Zeng
IPC: C12N15/11 , C12N15/10 , C12Q1/6869
Abstract: The present invention relates to a nucleic acid molecule capable of blocking motor protein, a library containing the nucleic acid molecule, a method for constructing the nucleic acid molecule or library containing the same, and an application of the nucleic acid molecule or library containing same. The nucleic acid molecule contains at the end a modified nucleotide capable of blocking a motor protein, and the modified nucleotide is as shown in Formula I or Formula I′:
-
Patent Agency Ranking
公开(公告)号：US20250066747A1
公开(公告)日：2025-02-27
申请号：US18723588
申请日：2021-12-31
Applicant: BGI Shenzhen
Inventor： Xun Xu , Fei Guo , Qiaoxia Hu , Denghui Li , Junyi Chen , Lele Wang , Ziyu Zhao , Zhouxiang Ji , Tao Zeng , Ou Wang , Yuxiang Li , Yuliang Dong , Wenwei Zhang
IPC: C12N9/14 , C12Q1/6869
Abstract: Provided is helicase BCH1X, which comprises an amino acid sequence represented by SEQ ID NO: 1 or 2. Further provided are a complex structure comprising helicase BCH1X and a binding moiety used for binding to a polynucleotide, and a use thereof in the control and characterization of a polynucleotide and in single molecule nanopore sequencing.
-
公开(公告)号：US20240392265A1
公开(公告)日：2024-11-28
申请号：US18564400
申请日：2021-09-08
Applicant: BGI SHENZHEN
Inventor： Lili Zhai , Qingqing Xie , Ruyin Cao , Yue Zheng , Yuliang Dong , Wenwei Zhang , Xun Xu , Zhuo Chen
IPC: C12N9/12 , C12Q1/6806 , C12Q1/6869
Abstract: Provided are a thermostable B-family DNA polymerase mutant and an application thereof. The thermostable B-family DNA polymerase mutant is provided to mutate amino acid residues in at least two of three sites of group A, i.e., 408, 409, and 410 in an amino acid sequence of thermostable B-family DNA polymerases to obtain proteins having DNA polymerase activity. A-group sites (408/409/410), B-group sites (451/485), C-group sites (389/383/384), D-group sites (589/67/680), E-group sites (491/493/494/497), and F-group sites (474/478/486/480/484) of several B-family DNA polymerases are analyzed to design the mutant.
-
公开(公告)号：US20240117425A1
公开(公告)日：2024-04-11
申请号：US18462652
申请日：2023-09-07
Applicant: MGI Tech Co., Ltd. , BGI Shenzhen
Inventor： Radoje Drmanac , Snezana Drmanac , Handong Li , Xun Xu , Matthew J. Callow , Leon Eckhardt , Naibo Yang
IPC: C12Q1/6874 , A61K47/00 , C07K16/28 , C07K16/44 , C12Q1/6804 , C12Q1/6869 , C12Q1/6876
CPC classification number: C12Q1/6874 , A61K47/00 , C07K16/2851 , C07K16/44 , C12Q1/6804 , C12Q1/6869 , C12Q1/6876 , C07K2317/73
Abstract: The invention provides compositions and methods for sequencing nucleic acids and other applications. In sequencing by synthesis, unlabeled reversible terminators are incorporated by a polymerase in each cycle, then labeled after incorporation by binding to the reversible terminator a directly or indirectly labeled antibody or other affinity reagent.
-
公开(公告)号：US11788138B2
公开(公告)日：2023-10-17
申请号：US17084482
申请日：2020-10-29
Applicant: MGI Tech Co., Ltd. , BGI Shenzhen
Inventor： Radoje Drmanac , Snezana Drmanac , Handong Li , Xun Xu , Matthew J. Callow , Leon Eckhardt , Naibo Yang
IPC: C12P19/34 , C12Q1/6874 , C12Q1/6876 , C07K16/44 , C12Q1/6804 , A61K47/00 , C12Q1/6869 , C07K16/28
CPC classification number: C12Q1/6874 , A61K47/00 , C07K16/2851 , C07K16/44 , C12Q1/6804 , C12Q1/6869 , C12Q1/6876 , C07K2317/73 , C12Q1/6804 , C12Q2525/186 , C12Q1/6869 , C12Q2525/186
Abstract: The invention provides compositions and methods for sequencing nucleic acids and other applications. In sequencing by synthesis, unlabeled reversible terminators are incorporated by a polymerase in each cycle, then labeled after incorporation by binding to the reversible terminator a directly or indirectly labeled antibody or other affinity reagent.
-
公开(公告)号：US20210035689A1
公开(公告)日：2021-02-04
申请号：US16967087
申请日：2018-04-17
Inventor： Xiaoqing Liu , Jiaxu Hong , Yong Ni , Shuangshuang Li , Lili Wang , Wei He , Youwen Guo , Yuxuan Liu , Yong Liu , Wei Wang , Ruiqi Xu , Jingyi Cheng , Lijia Tian , Wenbin Chen , Xun Xu
Abstract: The present disclosure proposes a modeling method and apparatus for diagnosing an ophthalmic disease based on artificial intelligence, and a storage medium. The modeling method includes: establishing a data collection of ophthalmic images and a data collection of non-image ophthalmic disease diagnosis questionnaires; training a first neural network model by employing the data collection of the ophthalmic images to obtain a first classification model; training a second classification model by employing the data collection of non-image ophthalmic disease diagnosis questionnaires; and merging the first classification model and the second classification model to obtain a target classification network model, in which, a test result outputted by the target classification network model is used as a diagnosis result of the ophthalmic disease.
-
-
-
-
-
-
-
-
-
Search Results
21
records
(took 0.015 seconds)
