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公开(公告)号:US20180305318A1
公开(公告)日:2018-10-25
申请号:US15771085
申请日:2016-10-28
申请人: BIOVENTURES, LLC , THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS (WASHINGTON, DC)
发明人: Jawahar L. Mehta , Magomed Khaidakov , Kottayil I. Varughese , Shraddha Thakkar , Yao Dai , Peter Crooks , Narsimha Reddy Penthala
IPC分类号: C07D231/12
CPC分类号: C07D231/12 , C07D231/14 , C07D231/38 , C07D233/22 , C07D233/28
摘要: Inhibitors of oxidized low-density lipoprotein receptor 1 (LOX-1), compositions comprising inhibitors of LOX-1, and methods of using thereof are described.
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2.
公开(公告)号:US10357474B2
公开(公告)日:2019-07-23
申请号:US15996101
申请日:2018-06-01
申请人: BioVentures, LLC , Universidad Tecnica Particular De Loja , The United States of America as Represented by the Department of Veterans Affairs
发明人: Cesar M. Compadre , Philip Breen , Nukhet Aykin-Burns , Martin Hauer-Jensen , Raul G. Enriquez , Sujay Kharade , Omar Malagon , Yadira Ordonez , Edgar Ojeda , Shraddha Thakkar , E. Nathalie Pineda , Darin Jones
IPC分类号: A61K31/355 , A61K36/185
摘要: Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise γ-tocotrienol (GT3) and δ-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.
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3.
公开(公告)号:US20180271829A1
公开(公告)日:2018-09-27
申请号:US15996101
申请日:2018-06-01
申请人: BioVentures, LLC , Universidad Tecnica Particular De Loja , The United States of America as Represented by the Department of Veterans Affairs
发明人: Cesar M. Compadre , Philip Breen , Nukhet Aykin-Burns , Martin Hauer-Jensen , Raul G. Enriquez , Sujay Kharade , Omar Malagon , Yadira Ordonez , Edgar Ojeda , Shraddha Thakkar , E. Nathalie Pineda , Darin Jones
IPC分类号: A61K31/355 , A61K36/185
CPC分类号: A61K31/355 , A61K36/185 , A61K2236/00 , A61K2236/35 , A61K2236/55
摘要: Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise γ-tocotrienol (GT3) and δ-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.
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公开(公告)号:US11465972B2
公开(公告)日:2022-10-11
申请号:US16721103
申请日:2019-12-19
申请人: United States Government as represented by the Department of Veterans Affairs , Bioventures, LLC
发明人: Jawahar L. Mehta , Magomed Khaidakov , Kottayil I. Varughese , Shraddha Thakkar , Yao Dai , Peter Crooks , Narsimha Reddy Penthala
IPC分类号: A61K31/4164 , A61K31/415 , C07D231/12 , C07D231/38 , C07D231/14 , C07D233/28 , C07D233/22
摘要: Inhibitors of oxidized low-density lipoprotein receptor 1 (LOX-1), compositions comprising inhibitors of LOX-1, and methods of using thereof are described.
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5.
公开(公告)号:US09993456B2
公开(公告)日:2018-06-12
申请号:US15021376
申请日:2014-09-15
申请人: BioVentures, LLC , Universidad Tecnica Particular De Loja , The United States of America as Represented by the Department of Veterans Affairs
发明人: Cesar M. Compadre , Philip Breen , Nukhet Aykin-Burns , Martin Hauer-Jensen , Raul G. Enriquez , Sujay Kharade , Omar Malagon , Yadira Ordonez , Edgar Ojeda , Shraddha Thakkar , E. Nathalie Pineda , Darin Jones
IPC分类号: A61K31/35 , A61K31/355 , A61K36/185
CPC分类号: A61K31/355 , A61K36/185 , A61K2236/00 , A61K2236/35 , A61K2236/55
摘要: Plant extracts, compositions, pharmaceutical compositions and methods of making and using the same are provided herein. The compositions comprise γ-tocotrienol (GT3) and δ-tocotrienol (DT3) in ratios wherein the DT3 is predominate. The compositions are useful for radioprotection and radiomitigation in subjects in need thereof.
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