公开(公告)号：US20240189540A1

公开(公告)日：2024-06-13

申请号：US18444933

申请日：2024-02-19

申请人： BioVentures, LLC

发明人： Erika Petersen ,  Mohamed Abdeldayem ,  Adria Abella Villafranca ,  Kevin Sexton ,  Joseph Sanford

IPC分类号： A61M21/00 ,  A61F5/37 ,  G06F3/01

CPC分类号： A61M21/00 ,  A61F5/37 ,  G06F3/011 ,  A61M2021/0022 ,  A61M2021/0027 ,  A61M2021/005

摘要： Disclosed herein is an immersive distraction apparatus including an attachment portion including an engagement element and a front plate having two cut outs fitting lenses therein and a base portion coupled with the attachment portion having a display aperture sized to receive a device. The immersive distraction apparatus mountable on a surgical head frame using one or more connectors such that an immersive distraction therapy can be provided to a patient undergoing surgery via a virtual reality environment.

公开(公告)号：US11987834B2

公开(公告)日：2024-05-21

申请号：US16433657

申请日：2019-06-06

申请人： BioVentures, LLC ,  Arkansas Children's Hospital Research Institute

发明人： Laura P. James ,  Jack Hinson ,  Dean Roberts ,  Pritmohinder S. Gill

IPC分类号： G01N33/53 ,  C07K14/47 ,  C12N9/10 ,  C12Q1/48 ,  C12Q1/527

CPC分类号： C12Q1/48 ,  C07K14/4708 ,  C12N9/1007 ,  C12N9/1014 ,  C12N9/107 ,  C12N9/1096 ,  C12Q1/527 ,  C12Y201/01005 ,  G01N33/53

摘要： The present disclosure relates to acetaminophen protein adducts and methods of diagnosing acetaminophen toxicity using the acetaminophen protein adducts.

公开(公告)号：US20240084389A1

公开(公告)日：2024-03-14

申请号：US17767784

申请日：2020-10-12

申请人： BioVentures, LLC

发明人： ANALIZ RODRIGUEZ ,  THIDATHIP WONGSURAWAT

IPC分类号： C12Q1/6886 ,  C12Q1/6869

CPC分类号： C12Q1/6886 ,  C12Q1/6869 ,  C12Q2600/106 ,  C12Q2600/154 ,  C12Q2600/156

摘要： The present disclosure relates to a method to detect simultaneously mutations and methylation levels in a biological sample of a subject. In particular the present disclosure is directed to a method for diagnosing a central nervous system tumor such as a diffuse glioma, in a subject and comprises the steps of—determining at the same time the presence or absence of a mutation and methylation levels in one or more regions of interest.

公开(公告)号：US20240059685A1

公开(公告)日：2024-02-22

申请号：US17766498

申请日：2020-10-05

申请人： BIOVENTURES, LLC

发明人： Hong-yu Li ,  Jinhu Xiong ,  Wei Yan ,  Charles O'Brien ,  Maria Schuller De Almeida

IPC分类号： C07D417/04 ,  A61P19/08

CPC分类号： C07D417/04 ,  A61P19/08

摘要： Disclosed herein are Piezo1 agonists. Also disclosed herein are methods of stimulating tissue anabolism in a subject comprising administering an effective amount of a Piezo1 agonist and methods for chemically mimicking mechanical stimulation of a cell expressing Piezo1 comprising contacting a cell expressing Piezo1 with an effective amount of a Piezo1 agonist.

公开(公告)号：US20230338220A1

公开(公告)日：2023-10-26

申请号：US17673323

申请日：2020-08-14

申请人： BioVentures, LLC ,  Arkansas Children's Hospital Research Institute, Inc.

发明人： Tara Johnson ,  Timothy Strasser ,  Landon Burcham ,  Jacob Scott ,  Ricardo Meza

IPC分类号： A61H1/02

CPC分类号： A61H1/0288 ,  A61H2201/0207 ,  A61H2201/1638 ,  A61H2201/0107 ,  A61H2201/169 ,  A61H2201/0228 ,  A61H2201/5007

摘要： An automated therapeutic device and methods thereof for heating and extending a patients curled fingers is provided. The device includes a rigid base extending from a patients hand to elbow, a plurality of fingerlets, each operable to attach to a finger of the patient, a plurality of extending elements, each extending element operable to reversibly attach to the rigid base and reversibly attach to one of the plurality of fingerlets, and a heating element operable to reversibly attach to the rigid base and distribute heat along the patient's anterior forearm.

公开(公告)号：US20230174814A1

公开(公告)日：2023-06-08

申请号：US17921955

申请日：2021-04-27

申请人： Soma Shekar DACHAVARAM ,  BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS ,  Bioventures, LLC

发明人： Soma Shekar Dachavaram ,  John P. Moore ,  Peter A. Crooks ,  Jamie Hestekin

IPC分类号： C09D101/04 ,  C09D5/14 ,  B82Y30/00

CPC分类号： C09D101/04 ,  C09D5/14 ,  B82Y30/00

摘要： A cellulose based anti-viral/anti-microbial coating.

公开(公告)号：US20230165520A1

公开(公告)日：2023-06-01

申请号：US17919474

申请日：2021-04-13

申请人： BioVentures, LLC ,  Arkansas Children's Hospital Research Institute ,  Board of Trustees of the University of Arkansas

发明人： KEVIN SEXTON ,  JINGXIAN WU ,  MORTEN JENSEN ,  HANNA JENSEN ,  MELVIN DASSINGER, III ,  KAYLEE HENRY ,  JOSEPH SANFORD ,  ALI AL-ALAWI ,  PATRICK BONASSO

IPC分类号： A61B5/00 ,  A61P23/00

CPC分类号： A61B5/4821 ,  A61P23/00 ,  A61B5/318

摘要： Disclosed herein are systems and methods for non-invasively predicting a hemodynamic state and/or an anesthetic depth of a patient, such as a pediatric patient. The method may include receiving a peripheral venous pressure (PVP) waveform from the patient, cleaning the PVP waveform, transforming the PVP waveform into the frequency domain, and automatically predicting the hemodynamic state and/or the anesthetic depth of the patient.

公开(公告)号：US11571255B2

公开(公告)日：2023-02-07

申请号：US17496995

申请日：2021-10-08

申请人： Bioventures, LLC

发明人： Vladimir Pavlovich Zharov ,  Ekaterina Galanzha

IPC分类号： A61B5/00 ,  A61B5/02 ,  A61B18/24 ,  A61B8/06 ,  A61B8/08 ,  A61K49/22 ,  B03C1/28 ,  B03C1/30 ,  G01N21/17 ,  G01N29/24 ,  G01N29/44 ,  A61B5/145 ,  A61B5/1495 ,  A61B18/18 ,  A61B18/20 ,  G01N15/14 ,  A61B18/00

摘要： A device and method of using the device to detect the presence and composition of clots and other target objects in a circulatory vessel of a living subject is described. In particular, devices and methods of detecting the presence and composition of clots and other target objects in a circulatory vessel of a living subject using in vivo photoacoustic flow cytometry techniques is described.

公开(公告)号：US20220332692A1

公开(公告)日：2022-10-20

申请号：US17857879

申请日：2022-07-05

申请人： BIOVENTURES, LLC ,  THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS

发明人： Cesar Compadre ,  Philip J. Breen ,  Martin Hauer-Jensen ,  Kottayil Varughese ,  K. Sree Kumar

IPC分类号： C07D311/72 ,  C07D311/58

摘要： Tocol derivative compounds, compositions comprising these tocol derivatives and methods of using the tocol derivatives are provided herein. Specifically the tocol derivatives have a partially unsaturated hydrocarbon tail and are thus distinct from the tocopherols. The hydrocarbon tails do not have a trans carbon-carbon double bond in the second isoprene unit of the hydrocarbon tail and are distinct from the tocotrienols. The compounds are expected to allow improved interaction with the a-tocopherol transfer protein receptor than the tocotrienols and better bioactivity than the tocopherols.

公开(公告)号：US20220034816A1

公开(公告)日：2022-02-03

申请号：US17389292

申请日：2021-07-29

申请人： TH Bioventures, LLC

发明人： Leif E. Honda ,  Phil A Cestaro ,  Jon C Wetzel ,  Songhao Li ,  Arsen Hajian ,  Ronald J. Sostek

IPC分类号： G01N21/65 ,  G01N33/569 ,  G01J3/44 ,  G01J3/02

摘要： A system and method for detecting pathogenetic analytes including exciting a large target input area with radiation to produce scattered light to form an input beam, reformatting, with an optical slicer system, the input beam to produce an output beam, dispersing the output beam to produce an output area, capturing excitation data from the output area; and determining, with a processor, a presence of a particular analyte in the input area based on the excitation data. The input area can be greater than 100 micron squared and less than one million microns squared. The optical slicer system can be a high throughput virtual slit system. SERS analysis detects analytes of interest with both high resolution and sensitivity simultaneously, and is applicable for detection of the presence of viruses.