公开(公告)号：US12134632B2

公开(公告)日：2024-11-05

申请号：US18153669

申请日：2023-01-12

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Glen Bolton ,  Keith Selvitelli

IPC: A61L2/00 ,  A61K35/14 ,  A61K35/16 ,  A61K38/00 ,  C07K1/16 ,  C07K1/22 ,  C07K14/755 ,  C07K16/06

Abstract: The present invention is directed to a method of inactivating virus that is present during production of a polypeptide of interest. In particular, the present invention is directed to a method of on-column virus inactivation using a low pH and high salt wash solution that effectively inactivates viruses with minimum recovery loss of the polypeptide.

公开(公告)号：US11578098B2

公开(公告)日：2023-02-14

申请号：US16793676

申请日：2020-02-18

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Glen Bolton ,  Keith Selvitelli

IPC: A61L2/00 ,  A61K38/00 ,  A61K35/16 ,  A61K35/14 ,  C07K1/22 ,  C07K16/06 ,  C07K1/16 ,  C07K14/755

Abstract: The present invention is directed to a method of inactivating virus that is present during production of a polypeptide of interest. In particular, the present invention is directed to a method of on-column virus inactivation using a low pH and high salt wash solution that effectively inactivates viruses with minimum recovery loss of the polypeptide.