公开(公告)号：US11372008B2

公开(公告)日：2022-06-28

申请号：US15979349

申请日：2018-05-14

Applicant: Bioverativ Therapeutics Inc.

Inventor： Jurg Sommer

IPC: G01N33/86 ,  G01N33/92 ,  A61K38/48

Abstract: The present disclosure provides methods and compositions for diagnosing and treating subject having a bleeding disorder. The disclosed methods comprise contacting a sample, e.g., a blood or plasma sample obtained from the patient, with an activation mixture comprising an activated coagulation factor and a phospholipid mixture, wherein the activation mixture is dried onto a solid substrate. Also provided is a global hemostasis test based on the integration of clotting time (Ct) and pharmacokinetics data. The methods and compositions presented can be applied to point-of-care diagnostic systems.

公开(公告)号：US11266720B2

公开(公告)日：2022-03-08

申请号：US16270302

申请日：2019-02-07

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Jennifer A. Dumont ,  Susan Low ,  Alan J. Bitonti ,  Glenn Pierce ,  Alvin Luk ,  Haiyan Jiang ,  Byron McKinney ,  Matt Ottmer ,  Jurg Sommer ,  Karen Nugent ,  Lian Li ,  Robert Peters

IPC: C07K14/755 ,  A61K38/37 ,  A61K47/64 ,  A61K47/68 ,  C07K16/46

Abstract: The present invention provides methods of administering Factor VIII; methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.

公开(公告)号：US10881742B2

公开(公告)日：2021-01-05

申请号：US15991629

申请日：2018-05-29

Applicant: Bioverativ Therapeutics Inc.

Inventor： Jennifer A. Dumont ,  Susan Low ,  Alan J. Bitonti ,  Glenn Pierce ,  Alvin Luk ,  Haiyan Jiang ,  Byron McKinney ,  Matt Ottmer ,  Jurg Sommer ,  Karen Nugent ,  Lian Li ,  Robert T. Peters

IPC: A61K38/37 ,  A61K47/68 ,  A61K47/60 ,  C07K14/755 ,  G01N33/86

Abstract: The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.

公开(公告)号：US12186375B2

公开(公告)日：2025-01-07

申请号：US17112280

申请日：2020-12-04

Applicant: Bioverativ Therapeutics Inc.

Inventor： Jennifer A. Dumont ,  Susan Low ,  Alan J. Bitonti ,  Glenn Pierce ,  Alvin Luk ,  Haiyan Jiang ,  Byron McKinney ,  Matt Ottmer ,  Jurg Sommer ,  Karen Nugent ,  Lian Li ,  Robert T. Peters

IPC: A61K38/37 ,  A61K47/60 ,  A61K47/68 ,  C07K14/755 ,  G01N33/86

Abstract: The present invention provides methods of administering Factor VIII (processed FVIII, single chain FVIII, or a combination thereof); methods of administering chimeric and hybrid polypeptides comprising Factor VIII; chimeric and hybrid polypeptides comprising Factor VIII; polynucleotides encoding such chimeric and hybrid polypeptides; cells comprising such polynucleotides; and methods of producing such chimeric and hybrid polypeptides using such cells.

公开(公告)号：US11747351B2

公开(公告)日：2023-09-05

申请号：US16848445

申请日：2020-04-14

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Jurg Sommer ,  Haiyan Jiang ,  Xin Zhang ,  Buyue Yang ,  Glenn Pierce

IPC: G01N33/86 ,  C12N9/64

CPC classification number: G01N33/86 ,  C12N9/644 ,  G01N2333/755 ,  G01N2333/9645 ,  G01N2333/974

Abstract: The present invention provides methods of dosing Factor VIII or Factor IX chimeric and hybrid polypeptides. The present invention further provides high-sensitivity methods of quantifying an amount of activated FIX protein in a test sample.

公开(公告)号：US10001495B2

公开(公告)日：2018-06-19

申请号：US14416214

申请日：2013-07-25

Applicant: Bioverativ Therapeutics Inc.

Inventor： Jurg Sommer

IPC: G01N33/86 ,  G01N33/92

CPC classification number: G01N33/86 ,  A61K38/4846 ,  C12Y304/21022 ,  G01N33/92 ,  G01N2333/755 ,  G01N2333/9645 ,  G01N2500/00 ,  G01N2800/224

Abstract: The present disclosure provides methods and compositions for diagnosing and treating subject having a bleeding disorder. The disclosed methods comprise contacting a sample, e.g., a blood or plasma sample obtained from the patient, with an activation mixture comprising an activated coagulation factor and a phospholipid mixture, wherein the activation mixture is dried onto a solid substrate. Also provided is a global hemostasis test based on the integration of clotting time (Ct) and pharmacokinetics data. The methods and compositions presented can be applied to point-of-care diagnostic systems.