公开(公告)号：US12275970B2

公开(公告)日：2025-04-15

申请号：US17060759

申请日：2020-10-01

Applicant: Bioverativ Therapeutics Inc.

Inventor： Siyuan Tan ,  Robert T. Peters ,  Tongyao Liu

IPC: C12N9/64

Abstract: The present invention provides codon optimized Factor IX sequences, vectors and host cells comprising codon optimized Factor IX sequences, polypeptides encoded by codon optimized Factor IX sequences, and methods of producing such polypeptides. The present invention also provides methods of treating bleeding disorders such as hemophilia comprising administering to the subject a codon optimized Factor IX nucleic acid sequence or the polypeptide encoded thereby.

公开(公告)号：US11787851B2

公开(公告)日：2023-10-17

申请号：US16452010

申请日：2019-06-25

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Siyuan Tan ,  Robert T. Peters

IPC: C07K14/755 ,  C12N9/64

CPC classification number: C07K14/755 ,  C12N9/6424 ,  C07K2319/30 ,  C07K2319/31

Abstract: The present invention provides codon optimized Factor VIII sequences, vectors and host cells comprising codon optimized Factor VIII sequences, polypeptides encoded by codon optimized Factor VIII sequences, and methods of producing such polypeptides.
The present invention also provides methods of treating bleeding disorders such as hemophilia comprising administering to the subject a codon optimized Factor VIII nucleic acid sequence or the polypeptide encoded thereby.

公开(公告)号：US11008561B2

公开(公告)日：2021-05-18

申请号：US15323302

申请日：2015-06-30

Applicant: BIOVERATIV THERAPEUTICS INC.

Inventor： Siyuan Tan ,  Robert T. Peters ,  Tongyao Liu

IPC: C07K14/745 ,  C07K14/755 ,  A61K48/00 ,  C12N9/64

Abstract: The present invention provides codon optimized Factor IX sequences, vectors and host cells comprising codon optimized Factor IX sequences, polypeptides encoded by codon optimized Factor IX sequences, and methods of producing such polypeptides. The present invention also provides methods of treating bleeding disorders such as hemophilia comprising administering to the subject a codon optimized Factor IX nucleic acid sequence or the polypeptide encoded thereby.

公开(公告)号：US11753461B2

公开(公告)日：2023-09-12

申请号：US16074729

申请日：2017-01-31

Applicant: Bioverativ Therapeutics Inc.

Inventor： Siyuan Tan ,  Tongyao Liu

IPC: C07H21/04 ,  C12N15/00 ,  C12N15/63 ,  A61K31/70 ,  C07K14/755 ,  A61K48/00 ,  C12N15/86 ,  A61P7/04 ,  C12N7/00 ,  A01K67/00 ,  A61K38/00

CPC classification number: C07K14/755 ,  A61K48/005 ,  A61K48/0016 ,  A61P7/04 ,  C12N7/00 ,  C12N15/86 ,  A61K38/00 ,  C07K2319/02 ,  C07K2319/30 ,  C07K2319/31 ,  C12N2740/15043 ,  C12N2740/16043 ,  C12N2800/22

Abstract: The present disclosure provides codon optimized Factor VIII sequences, vectors, and host cells comprising codon optimized Factor VIII sequences, polypeptides encoded by codon optimized Factor VIII sequences, and methods of producing such polypeptides. The present disclosure also provides methods of treating bleeding disorders such as hemophilia comprising administering to the subject a codon optimized Factor VIII nucleic acid sequence or the polypeptide encoded thereby.

公开(公告)号：US20200318140A1

公开(公告)日：2020-10-08

申请号：US16839947

申请日：2020-04-03

Applicant: Bioverativ Therapeutics, Inc. ,  MaxCyte, Inc. ,  Sangamo Therapeutics, Inc.

Inventor： Siyuan Tan ,  Dale Ando ,  Andreas Reik ,  Linhong Li ,  Madhusudan V. Peshwa ,  Haiyan Jiang

IPC: C12N15/90 ,  A61K48/00 ,  C12N15/87

Abstract: Disclosed herein are methods and compositions for increasing RNA activity in a cell.

公开(公告)号：US10370431B2

公开(公告)日：2019-08-06

申请号：US14767425

申请日：2014-02-14

Applicant: Bioverativ Therapeutics Inc.

Inventor： Siyuan Tan ,  Robert T. Peters

IPC: C07K14/755 ,  C12N9/64

Abstract: The present invention provides codon optimized Factor VIII sequences, vectors and host cells comprising codon optimized Factor VIII sequences, polypeptides encoded by codon optimized Factor VIII sequences, and methods of producing such polypeptides.