公开(公告)号：US20130245234A1

公开(公告)日：2013-09-19

申请号：US13738518

申请日：2013-01-10

申请人： BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM

发明人： Steven J. NORRIS ,  Jing-Ren ZHANG ,  John M. HARDHAM ,  Jerrilyn K. HOWELL ,  Alan G. BARBOUR ,  George M. WEINSTOCK

IPC分类号： C07K16/12

CPC分类号： C07K16/1207 ,  A61K38/00 ,  A61K39/00 ,  A61K39/02 ,  A61K39/40 ,  A61K39/44 ,  C07B59/008 ,  C07B2200/05 ,  C07B2200/11 ,  C07K14/20 ,  C07K2319/00 ,  G01N33/56911 ,  G01N2333/20 ,  G11B7/0065 ,  G11B7/00772 ,  G11B7/128 ,  Y02A50/40 ,  Y02A50/401 ,  Y02A50/57

摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borreliae, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.

摘要翻译： 本发明涉及编码致病性疏螺旋体的Vmp样多肽的DNA序列，重组载体中的DNA序列用于表达多肽的用途，编码的氨基酸序列，DNA和氨基酸序列在产生抗原中的应用 用于免疫预防，免疫治疗和免疫诊断。 还公开了使用核酸序列作为检测引起莱姆病，复发性发热或相关病症的生物的探针或引物，以及旨在促进使用所述多肽，DNA区段和抗体的方法的试剂盒。

公开(公告)号：US20160266112A1

公开(公告)日：2016-09-15

申请号：US14968842

申请日：2015-12-14

申请人： Board of Regents, The University of Texas System

发明人： Steven J. NORRIS ,  Jing-Ren ZHANG ,  John M. HARDHAM ,  Jerrilyn K. HOWELL ,  Alan G. BARBOUR ,  George M. WEINSTOCK

IPC分类号： G01N33/569 ,  C07K16/12 ,  C07K14/20 ,  C07B59/00

摘要： The present invention relates to DNA sequences encoding Vmp-like polypeptides of pathogenic Borreliae, the use of the DNA sequences in recombinant vectors to express polypeptides, the encoded amino acid sequences, application of the DNA and amino acid sequences to the production of polypeptides as antigens for immunoprophylaxis, immunotherapy, and immunodiagnosis. Also disclosed are the use of the nucleic acid sequences as probes or primers for the detection of organisms causing Lyme disease, relapsing fever, or related disorders, and kits designed to facilitate methods of using the described polypeptides, DNA segments and antibodies.