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公开(公告)号：US20220362264A1
公开(公告)日：2022-11-17
申请号：US17437144
申请日：2020-03-17
摘要： The present disclosure relates to pharmaceutical formulations including abiraterone and a cyclic oligomer, as well as tablets including such pharmaceutical formulations, methods of forming such pharmaceutical formulations, and methods of administering such pharmaceutical formulations or tablets.
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公开(公告)号：US20160250230A1
公开(公告)日：2016-09-01
申请号：US15154083
申请日：2016-05-13
发明人： Chris BROUGH , James W. MCGINITY , Dave A. MILLER , James C. DINUNZIO , Robert O. WILLIAMS, III
IPC分类号： A61K31/573 , A61J3/10 , A61K47/32 , A61K31/496 , A61K31/343 , A61J3/07 , A61K47/38
CPC分类号： A61K31/573 , A61J3/00 , A61J3/07 , A61J3/10 , A61K9/146 , A61K9/1694 , A61K9/2077 , A61K31/343 , A61K31/496 , A61K47/32 , A61K47/38
摘要： Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
摘要翻译： 用于制备药物剂型的组合物和方法包括制备药物组合物，其包含一种或多种活性药物成分（API）与一种或多种药学上可接受的赋形剂，通过热动力学复合制成复合材料。 将包含一种或多种API的复合材料与一种或多种赋形剂预处理的组合物和方法包括热动力学复合，其包括将所述API与所述赋形剂的热机械加工成复合材料，其中所述复合材料可以通过本领域已知的常规方法进一步加工， 热熔挤出，熔融造粒，压缩成型，片剂压缩，胶囊填充，薄膜包衣或注塑成型。
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公开(公告)号：US20220401579A1
公开(公告)日：2022-12-22
申请号：US17777102
申请日：2020-09-24
IPC分类号： A61K47/69 , A61K31/496 , A61K31/44 , A61K31/5377
摘要： Pharmaceutical formulations including an inclusion complex of an API with a cyclic oligomer, and methods of forming such pharmaceutical formulations are described.
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公开(公告)号：US20210128536A1
公开(公告)日：2021-05-06
申请号：US17065664
申请日：2020-10-08
IPC分类号： A61K31/444 , A61K47/38 , A61K47/32 , A61K9/16 , A61K9/00 , A61K31/496 , A61K31/136 , A61K31/704 , A61K31/475 , A61K31/167 , A61K31/5415
摘要： The present disclosure relates to pharmaceutical formulations including a weakly basic drug and an ionic polymer in an amorphous solid dispersion, as well as methods of forming such pharmaceutical formulations, and methods of administering such pharmaceutical formulations.
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公开(公告)号：US20200261473A1
公开(公告)日：2020-08-20
申请号：US16866676
申请日：2020-05-05
发明人： Chris BROUGH , James W. MCGINITY , Dave A. MILLER , James C. DINUNZIO , Robert O. WILLIAMS, III
IPC分类号： A61K31/573 , A61K47/38 , A61K47/32 , A61K31/496 , A61K31/343 , A61J3/10 , A61J3/07 , A61J3/00 , A61K9/20 , A61K9/16 , A61K9/14
摘要： Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can he further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
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公开(公告)号：US20180360850A1
公开(公告)日：2018-12-20
申请号：US16012025
申请日：2018-06-19
发明人： Chris BROUGH , James W. MCGINITY , Dave A. MILLER , James C. DINUNZIO , Robert O. WILLIAMS, III
IPC分类号： A61K31/573 , A61K9/16 , A61K9/20 , A61K9/14 , A61J3/10 , A61K47/32 , A61K31/496 , A61K31/343 , A61J3/00 , A61K47/38 , A61J3/07
摘要： Compositions and methods for making a pharmaceutical dosage form include making a pharmaceutical composition that includes one or more active pharmaceutical ingredients (API) with one or more pharmaceutically acceptable excipients by thermokinetic compounding into a composite. Compositions and methods of preprocessing a composite comprising one or more APIs with one or more excipients include thermokinetic compounding, comprising thermokinetic processing the APIs with the excipients into a composite, wherein the composite can be further processed by conventional methods known in the art, such as hot melt extrusion, melt granulation, compression molding, tablet compression, capsule filling, film-coating, or injection molding.
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公开(公告)号：US20240342091A1
公开(公告)日：2024-10-17
申请号：US18634454
申请日：2024-04-12
CPC分类号： A61K9/1682 , A61K9/1658 , B01D9/005 , Y10T428/2982
摘要： The present invention includes compositions and methods for preparing micron-sized or submicron-sized particles by dissolving a water soluble effective ingredient in one or more solvents; spraying or dripping droplets solvent such that the effective ingredient is exposed to a vapor-liquid interface of less than 50, 100, 150, 200, 250, 200, 400 or 500 cm−1 area/volume to, e.g., increase protein stability; and contacting the droplet with a freezing surface that has a temperature differential of at least 30° C. between the droplet and the surface, wherein the surface freezes the droplet into a thin film with a thickness of less than 500 micrometers and a surface area to volume between 25 to 500 cm−1.
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公开(公告)号：US20240269225A1
公开(公告)日：2024-08-15
申请号：US18434731
申请日：2024-02-06
发明人： Robert O. WILLIAMS, III , Alan B. WATTS , Yajie ZHANG , Sawittree SAHAKIJPIJARN , Dale CHRISTENSEN , John J. KOLENG
CPC分类号： A61K38/08 , A61K9/0075 , A61K9/14 , A61K38/10 , A61K45/06 , A61P11/00 , C07K7/06 , C07K7/08 , C07K2319/10
摘要： Provided herein are compositions comprising caveolin-1 (Cav-1) peptides. Further provided are methods of using the Cav-1 peptides for the treatment of lung infections or acute or chronic lung injury, particularly lung fibrosis.
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公开(公告)号：US20240165045A1
公开(公告)日：2024-05-23
申请号：US18549645
申请日：2022-03-08
IPC分类号： A61K9/51 , A61K39/215
CPC分类号： A61K9/5123 , A61K9/5192 , A61K39/215 , A61K2039/53
摘要： In some aspects, the present disclosure provides dry powder pharmaceutical compositions comprising: (A) a nucleic acid; (B) a lipid nanoparticle; wherein the nucleic acid is substantially encapsulated in the lipid nanoparticle; (C) a sugar; and (D) a pharmaceutically acceptable polymer. The dry powder composition may show improved stability relative to solution based pharmaceutical composition of nucleic acid therapeutic agents encapsulated in a lipid nanoparticle.
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公开(公告)号：US20230263816A1
公开(公告)日：2023-08-24
申请号：US18005522
申请日：2021-07-16
发明人： Robert O. WILLIAMS, III , Chaeho MOON , Sawittree SAHAKIJPIJARN , Dale CHRISTENSEN , Glenn MATTES , John J. KOLENG
CPC分类号： A61K31/706 , A61K9/0075 , A61K47/183 , A61K47/26 , A61K47/40 , A61K45/06
摘要： The present disclosure provides pharmaceutical compositions of remdesivir that may be administered by inhalation. These compositions may allow the achievement of a therapeutically effective dose of remdesivir directly to the lungs. These compositions may be used to treat one or more diseases or disorders such as a viral infection like an infection of a coronavirus.
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