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公开(公告)号：US20190100740A1
公开(公告)日：2019-04-04
申请号：US15724196
申请日：2017-10-03
申请人： Bolt Threads, Inc.
IPC分类号： C12N9/60 , C07K14/435
摘要： Disclosed herein are modified strains for reducing degradation of recombinantly expressed products secreted from a host organism and methods of using the modified strains.
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公开(公告)号：US20200283750A1
公开(公告)日：2020-09-10
申请号：US16842498
申请日：2020-04-07
申请人： Bolt Threads, Inc.
IPC分类号： C12N9/60 , C07K14/435
摘要： Disclosed herein are modified strains for reducing degradation of recombinantly expressed products secreted from a host organism and methods of using the modified strains. In some embodiments, to attenuate a protease activity in Pichia pastoris, the genes encoding enzymes the degrade proteases are inactivated or mutated to reduce or eliminate activity. In preferred strains, the protease activity of proteases encoded by PAS_chr4_0584 (YPS1-1) and PAS_chr3_1157 (YPS1-2) (e.g., polypeptides comprising SEQ ID NO: 66 and 67) is attenuated.
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公开(公告)号：US20240050352A1
公开(公告)日：2024-02-15
申请号：US18017216
申请日：2021-07-16
申请人： BOLT THREADS, INC.
CPC分类号： A61K8/64 , A61K8/0279 , A61Q19/00 , A61Q19/10 , A61K2800/28
摘要： Disclosed herein are recombinant spider silk compositions formed from a stable powder as it hydrates, cleanses, defends, detoxifies, mattifies, and/or exfoliates the skin, among other uses.
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公开(公告)号：US20230055130A1
公开(公告)日：2023-02-23
申请号：US17792176
申请日：2020-12-16
申请人： BOLT THREADS, INC.
摘要： Provided herein are mycelium materials and methods for production thereof. In some embodiments, a mycelium material includes: a cultivated mycelium material including one or more masses of branching hyphae, wherein the one or more masses of branching hyphae may be disrupted and/or a bonding agent may be combined with the cultivated mycelium material. Methods of producing a mycelium material are also provided.
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公开(公告)号：US20220251533A1
公开(公告)日：2022-08-11
申请号：US17527429
申请日：2021-11-16
申请人： Bolt Threads, Inc.
IPC分类号： C12N9/60 , C07K14/435
摘要： Disclosed herein are modified strains for reducing degradation of recombinantly expessed products secreted from a host organism and methods of using the modified strains. In some embodiments, to attenuate a protease activity in Pichia pastoris, the genes encoding enzymes the degrade proteases are inactivated or mutated to reduce or eliminate activity. In preferred strains, the protease activity of proteases encoded by PAS_chr4_0584 (YPS1-1) and PAS_chr3_1157 (YPS1-2) (e.g., polypeptides comprising SEQ ID NO: 66 and 67) is attenuated.
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公开(公告)号：US11214785B2
公开(公告)日：2022-01-04
申请号：US16842498
申请日：2020-04-07
申请人： Bolt Threads, Inc.
IPC分类号： C12N9/60 , C07K14/435
摘要： Disclosed herein are modified strains for reducing degradation of recombinantly expressed products secreted from a host organism and methods of using the modified strains. In some embodiments, to attenuate a protease activity in Pichia pastoris, the genes encoding enzymes the degrade proteases are inactivated or mutated to reduce or eliminate activity. In preferred strains, the protease activity of proteases encoded by PAS_chr4_0584 (YPS1-1) and PAS_chr3_1157 (YPS1-2) (e.g., polypeptides comprising SEQ ID NO: 66 and 67) is attenuated.
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公开(公告)号：US10647975B2
公开(公告)日：2020-05-12
申请号：US15724196
申请日：2017-10-03
申请人： Bolt Threads, Inc.
IPC分类号： C12N9/60 , C07K14/435
摘要： Disclosed herein are modified strains for reducing degradation of recombinantly expressed products secreted from a host organism and methods of using the modified strains. In some embodiments, to attenuate a protease activity in Pichia pastoris, the genes encoding enzymes the degrade proteases are inactivated or mutated to reduce or eliminate activity. In preferred strains, the protease activity of proteases encoded by PAS_chr4_0584 (YPS1-1) and PAS_chr3_1157 (YPS1-2) (e.g., polypeptides comprising SEQ ID NO: 66 and 67) is attenuated.
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