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公开(公告)号：US20190093257A1
公开(公告)日：2019-03-28
申请号：US16141787
申请日：2018-09-25
申请人： Bolt Threads, Inc.
发明人： Amir Ahmad Bakhtiary Davijani , Steven Tom , Maxime Boulet-Audet , Paul Andre Guerette , Lindsay Wray , Nicole Elizabeth Subler , Zoya Nasir Zulfiqar , Hua Li , Jessica Wang
摘要： Provided herein are scalable methods of processing wet-spun fiber comprising recombinant spider silk polypeptides to generate a three-dimensional crystalline lattice of beta-sheet structures in the fiber.
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公开(公告)号：US20180282937A1
公开(公告)日：2018-10-04
申请号：US15920306
申请日：2018-03-13
申请人： Bolt Threads, Inc.
发明人： Jamie McAusland Bainbridge , Lindsay Wray , Mitchell Heinrich , Joshua Kittleson , David N. Breslauer
IPC分类号： D06M13/144 , C07K14/435 , D06B3/10 , D02G3/02 , D02G3/38 , D04B1/14
摘要： The present disclosure relates generally to pre-treating textiles and methods of preparing textiles in a pre-treated state. Specifically, the present disclosure relates to pre-treating textiles comprising recombinant protein fibers.
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公开(公告)号：US20230064786A1
公开(公告)日：2023-03-02
申请号：US17819126
申请日：2022-08-11
申请人： BOLT THREADS, INC.
IPC分类号： C07K14/435 , D01F4/00 , C12N15/81 , D01B7/00 , D02G3/04
摘要： The present disclosure provides improved long uniform recombinant protein fibers with desirable physical traits. The present disclosure also provides compositions derived from the long uniform recombinant protein fibers.
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公开(公告)号：US10435516B2
公开(公告)日：2019-10-08
申请号：US15945673
申请日：2018-04-04
申请人： Bolt Threads, Inc.
IPC分类号： C08H1/00 , C12N15/80 , C12N15/74 , B29C48/00 , B29C48/88 , C12P21/02 , D01F4/00 , D01F4/02 , D01F6/68 , C07K14/435 , C12P21/00 , D01D1/02 , D01D5/00 , D01F11/02 , B29L31/00
摘要： The present disclosure provides methods and compositions for directed to synthetic block copolymer proteins, expression constructs for their secretion, recombinant microorganisms for their production, and synthetic fibers (including advantageously, microfibers) comprising these proteins that recapitulate many properties of natural silk. The recombinant microorganisms can be used for the commercial production of silk-like fibers.
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公开(公告)号：US10035886B2
公开(公告)日：2018-07-31
申请号：US15285256
申请日：2016-10-04
申请人： Bolt Threads, Inc.
IPC分类号： C08H1/00 , C07K14/435 , B29C47/00 , B29C47/88 , D01F4/02 , D01F6/68 , D01D1/02 , D01D5/00 , D01F11/02 , B29L31/00
CPC分类号： C08H1/00 , B29C48/022 , B29C48/919 , B29K2089/00 , B29K2995/0077 , B29L2031/731 , C07K14/43518 , C07K14/43586 , C07K2319/02 , C07K2319/43 , C12P21/00 , C12P21/02 , D01D1/02 , D01D5/00 , D01F4/00 , D01F4/02 , D01F6/68 , D01F11/02
摘要： The present disclosure provides methods and compositions for directed to synthetic block copolymer proteins, expression constructs for their secretion, recombinant microorganisms for their production, and synthetic fibers (including advantageously, microfibers) comprising these proteins that recapitulate many properties of natural silk. The recombinant microorganisms can be used for the commercial production of silk-like fibers.
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公开(公告)号：US11447532B2
公开(公告)日：2022-09-20
申请号：US15705185
申请日：2017-09-14
申请人： Bolt Threads, Inc.
IPC分类号： C07K14/435 , D01F4/00 , C12N15/81 , D01B7/00 , D02G3/04 , D01D5/06 , D06M101/12
摘要： The present disclosure provides improved long uniform recombinant protein fibers with desirable physical traits. The present disclosure also provides compositions derived from the long uniform recombinant protein fibers.
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公开(公告)号：US11208736B2
公开(公告)日：2021-12-28
申请号：US16141787
申请日：2018-09-25
申请人： Bolt Threads, Inc.
发明人： Amir Ahmad Bakhtiary Davijani , Steven Tom , Maxime Boulet-Audet , Paul Andre Guerette , Lindsay Wray , Nicole Elizabeth Subler , Zoya Nasir Zulfiqar , Hua Li , Jessica Wang
摘要： Provided herein are scalable methods of processing wet-spun fiber comprising recombinant spider silk polypeptides to generate a three-dimensional crystalline lattice of beta-sheet structures in the fiber.
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公开(公告)号：US20190389916A1
公开(公告)日：2019-12-26
申请号：US16409480
申请日：2019-05-10
申请人： Bolt Threads, Inc.
发明人： Gregory Wilson Rice , Steven Tom , Hua Li , Amir Ahmad Bakhtiary Davijani , Jessica Wang , Lindsay Wray , Sandra Lorena Castano Garcia , Zoya Nasir Zulfiqar , Jeroen Visjager
IPC分类号： C07K14/435 , D02J11/00 , D01F2/24 , D01F11/02
摘要： Provided herein are scalable methods of spinning fiber comprising bi-constituent blends of cellulose and recombinant spider silk polypeptides. Also provided are compositions comprising blended fibers of cellulose and recombinant spider silk polypeptides.
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公开(公告)号：US20180298151A1
公开(公告)日：2018-10-18
申请号：US16016483
申请日：2018-06-22
申请人： Bolt Threads, Inc.
IPC分类号： C08H1/00 , D01F11/02 , B29C47/00 , D01F4/02 , D01F4/00 , D01D5/00 , D01D1/02 , C12P21/02 , C12P21/00 , D01F6/68 , B29C47/88 , C07K14/435 , B29L31/00
摘要： The present disclosure provides methods and compositions for directed to synthetic block copolymer proteins, expression constructs for their secretion, recombinant microorganisms for their production, and synthetic fibers (including advantageously, microfibers) comprising these proteins that recapitulate many properties of natural silk. The recombinant microorganisms can be used for the commercial production of silk-like fibers.
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公开(公告)号：US20180273693A1
公开(公告)日：2018-09-27
申请号：US15945673
申请日：2018-04-04
申请人： Bolt Threads, Inc.
CPC分类号： C08H1/00 , B29C48/022 , B29C48/919 , B29K2089/00 , B29K2995/0077 , B29L2031/731 , C07K14/43518 , C07K14/43586 , C07K2319/02 , C07K2319/43 , C12P21/00 , C12P21/02 , D01D1/02 , D01D5/00 , D01F4/00 , D01F4/02 , D01F6/68 , D01F11/02
摘要： The present disclosure provides methods and compositions for directed to synthetic block copolymer proteins, expression constructs for their secretion, recombinant microorganisms for their production, and synthetic fibers (including advantageously, microfibers) comprising these proteins that recapitulate many properties of natural silk. The recombinant microorganisms can be used for the commercial production of silk-like fibers.
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