COMPOSITIONS, DEVICES AND METHODS FOR MULTI-STAGE RELEASE OF CHEMOTHERAPEUTICS
    6.
    发明申请
    COMPOSITIONS, DEVICES AND METHODS FOR MULTI-STAGE RELEASE OF CHEMOTHERAPEUTICS 审中-公开
    化疗药物多阶段释放的组合物,装置和方法

    公开(公告)号:US20160184233A1

    公开(公告)日:2016-06-30

    申请号:US14980371

    申请日:2015-12-28

    Abstract: In one aspect, the present disclosure provides microparticles that are configured to release a first drug over a first time period and to release a second drug over a second time period, wherein a lag period of substantially no drug release occurs between the first and second time periods. In other aspects, the present disclosure pertains to the use of such microparticles in delivery systems and methods of treatment. In another aspect, the present disclosure pertains to drug delivery systems that comprising a folded inflatable drug delivery balloon that comprises folds and microparticles positioned within the folds.

    Abstract translation: 一方面,本公开提供了微粒,其构造成在第一时间段内释放第一药物并且在第二时间段内释放第二药物,其中在第一和第二时间之间基本上不发生药物释放的滞后期 时期。 在其他方面,本公开涉及这种微粒在递送系统和治疗方法中的用途。 在另一方面,本公开涉及药物递送系统,其包括折叠的可膨胀药物递送球囊,其包括位于折叠内的褶皱和微粒。

    MEDICAL DEVICE WITH BLADE ASSEMBLY

    公开(公告)号:US20240398439A1

    公开(公告)日:2024-12-05

    申请号:US18677293

    申请日:2024-05-29

    Abstract: A medical device may include an inflatable balloon secured to a distal region of a catheter shaft. A blade assembly may extend over and be secured to the inflatable balloon. The blade assembly may include a plurality of blades and at least two rings that are adapted to secure each of the plurality of blades. Each of the rings include an inner surface adapted to be secured to the inflatable balloon and an outer surface. A number of living hinges are formed within the inner surface and the outer surface that cooperate to allow the blade assembly to move between an expanded configuration and a collapsed configuration.

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