公开(公告)号：US20170210692A1

公开(公告)日：2017-07-27

申请号：US15315401

申请日：2015-06-10

申请人： BRACCO IMAGING S.P.A.

发明人： Roberta FRETTA ,  Pietro DELOGU ,  Fernanda DI GIORGIO ,  Alfonso NARDELLI ,  Stefano SGUASSERO ,  Carlo Felice VISCARDI

IPC分类号： C07C67/08 ,  B01D3/00 ,  C07C67/287 ,  C07C51/44 ,  C07C67/54

CPC分类号： C07C67/08 ,  B01D3/009 ,  C07B2200/07 ,  C07C51/44 ,  C07C67/287 ,  C07C67/54 ,  C07C69/63 ,  C07C69/14 ,  C07C53/08 ,  C07C59/08

摘要： The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.

公开(公告)号：US20180222840A1

公开(公告)日：2018-08-09

申请号：US15946204

申请日：2018-04-05

申请人： BRACCO IMAGING S.P.A.

发明人： Roberta FRETTA ,  Pietro DELOGU ,  Fernanda DI GIORGIO ,  Alfonso NARDELLI ,  Stefano SGUASSERO ,  Carlo Felice VISCARDI

IPC分类号： C07C67/08 ,  C07C51/44 ,  C07C67/287 ,  C07C67/54 ,  B01D3/00

CPC分类号： C07C67/08 ,  B01D3/009 ,  C07B2200/07 ,  C07C51/44 ,  C07C67/287 ,  C07C67/54 ,  C07C69/63 ,  C07C69/14 ,  C07C53/08 ,  C07C59/08

摘要： The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid.The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.

公开(公告)号：US20190225570A1

公开(公告)日：2019-07-25

申请号：US16276252

申请日：2019-02-14

申请人： BRACCO IMAGING S.P.A.

发明人： Roberta FRETTA ,  Pietro DELOGU ,  Fernanda DI GIORGIO ,  Alfonso NARDELLI ,  Stefano SGUASSERO ,  Carlo Felice VISCARDI

IPC分类号： C07C67/08 ,  C07C67/54 ,  B01D3/00 ,  C07C67/287 ,  C07C51/44

摘要： The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid.The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.

公开(公告)号：US20150329464A1

公开(公告)日：2015-11-19

申请号：US14650868

申请日：2013-12-04

申请人： BRACCO IMAGING S.P.A.

发明人： Silvia CERAGIOLI ,  Pietro DELOGU ,  Armando MORTILLARO ,  Alfonso NARDELLI ,  Stefano SGUASSERO ,  Rosario VELARDI ,  Carlo Felice VISCARDI

IPC分类号： C07C67/313 ,  C07C71/00

CPC分类号： C07C67/313 ,  C07C67/08 ,  C07C67/287 ,  C07C71/00 ,  Y02P20/582 ,  C07C69/14

摘要： The present invention relates to a continuous method for the preparation of (S)-2-acetyloxypropionic acid from an aqueous solution of lactic acid and acetic anhydride, in acetic acid. (S)-2-acetyloxypropionic acid is used for the preparation of (S)-2-acetyloxypropionic acid chloride, an essential intermediate compound for the preparation of lopamidol and has to be industrially produced with high purity and suitable quality for producing lopamidol according to the Pharmacopoeia requirements. The continuous process according to the invention, comprises therefore also the chlorination steps of (S)-2-acetyloxypropionic acid with thionyl chloride to give the corresponding (S)-2-acetyloxypropionic acid chloride which is further distilled to give the suitable purity characteristics for its use for the preparation of non-ionic iodinated contrast agents as lopamidol.

摘要翻译： 本发明涉及在乙酸中由乳酸和乙酸酐的水溶液制备（S）-2-乙酰氧基丙酸的连续方法。 （S）-2-乙酰氧基丙酸用于制备（S）-2-乙酰氧基丙酸氯化物，其是制备洛帕糖醇的必需中间体化合物，并且必须在工业上以高纯度生产，并且根据 药典要求。 根据本发明的连续方法还包括（S）-2-乙酰氧基丙酸与亚硫酰氯的氯化步骤，得到相应的（S）-2-乙酰氧基丙酰氯，进一步蒸馏得到适合的纯度特性， 其用于制备非离子碘化造影剂作为洛帕糖醇。