-
公开(公告)号：US20170210692A1
公开(公告)日：2017-07-27
申请号：US15315401
申请日：2015-06-10
Applicant: BRACCO IMAGING S.P.A.
Inventor： Roberta FRETTA , Pietro DELOGU , Fernanda DI GIORGIO , Alfonso NARDELLI , Stefano SGUASSERO , Carlo Felice VISCARDI
IPC: C07C67/08 , B01D3/00 , C07C67/287 , C07C51/44 , C07C67/54
CPC classification number: C07C67/08 , B01D3/009 , C07B2200/07 , C07C51/44 , C07C67/287 , C07C67/54 , C07C69/63 , C07C69/14 , C07C53/08 , C07C59/08
Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid. The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
-
公开(公告)号：US20200071341A1
公开(公告)日：2020-03-05
申请号：US16678082
申请日：2019-11-08
Applicant: BRACCO IMAGING S.P.A.
Inventor： Roberta MAZZON , Roberta FRETTA , Pier Lucio ANELLI
Abstract: The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.
-
公开(公告)号：US20230046541A1
公开(公告)日：2023-02-16
申请号：US17786623
申请日：2020-12-17
Applicant: BRACCO IMAGING S.P.A.
Inventor： Andrea BANIN , Laura GALIMBERTI , Roberta NAPOLITANO , Roberta FRETTA
IPC: C07C229/22 , C07C227/18
Abstract: The present invention relates to the calcium complex of (4RS)(4-carboxy-5,8,11-tris(carboxymethyl)-1-phenyl oxa-5,8,11-triazatridecan-13-oato(5-))pentahydrogen (BOPTA) in the form of a salt, to the process for its preparation and to a formulation comprising said salt.
-
Patent Agency Ranking
公开(公告)号：US20180222840A1
公开(公告)日：2018-08-09
申请号：US15946204
申请日：2018-04-05
Applicant: BRACCO IMAGING S.P.A.
Inventor： Roberta FRETTA , Pietro DELOGU , Fernanda DI GIORGIO , Alfonso NARDELLI , Stefano SGUASSERO , Carlo Felice VISCARDI
IPC: C07C67/08 , C07C51/44 , C07C67/287 , C07C67/54 , B01D3/00
CPC classification number: C07C67/08 , B01D3/009 , C07B2200/07 , C07C51/44 , C07C67/287 , C07C67/54 , C07C69/63 , C07C69/14 , C07C53/08 , C07C59/08
Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid.The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
-
公开(公告)号：US20170190719A1
公开(公告)日：2017-07-06
申请号：US15321176
申请日：2015-07-20
Applicant: BRACCO IMAGING S.P.A.
Inventor： Roberta MAZZON , Roberta FRETTA , Pier Lucio ANELLI
Abstract: The present invention relates to a process for the preparation of a solid form of the gadobenate dimeglumine compound that comprises obtaining a solution of the said compound in a suitable solvent A wherein the amount by weight of the water optionally present in the solution is at most equal to or lower than the amount by weight of the gadobenate dimeglumine comprised in the solution and adding the obtained solution to an organic solvent B, acting as an appropriate antisolvent and favoring the formation of a solid form of the gadobenate dimeglumine that can be collected by filtration.
-
6.发明申请公开(公告)号：US20160228583A1
公开(公告)日：2016-08-11
申请号：US15130160
申请日：2016-04-15
Applicant: BRACCO IMAGING S.p.A.
Inventor： Pier Lucio ANELLI , Pierfrancesco MOROSINI , Silvia CERAGIOLI , Fulvio UGGERI , Luciano LATTUADA , Roberta FRETTA , Aurelia FERRIGATO
IPC: A61K49/18 , C07C213/10 , B29C67/24 , C07C227/40
CPC classification number: A61K49/1887 , A61K9/0019 , B29C67/24 , C07C213/10 , C07C227/38 , C07C227/40 , Y10T428/2982 , C07C229/22
Abstract: The present invention discloses a process for the preparation of gadobenate dimeglumine complex in a solid form. In particular, said solid form is conveniently obtained by spray-drying a corresponding liquid suspension at a given temperature and concentration. The present invention is particularly advantageous for the industrial scale as the solid form may be obtained by employing water as a solvent, which is a non-toxic solvent, easy to handle and basically not requiring troublesome health or safety precautions.
Abstract translation: 本发明公开了一种以固体形式制备钆酸二甲酚络合物的方法。 特别地，所述固体形式通过在给定温度和浓度下喷雾干燥相应的液体悬浮液而方便地得到。 本发明对于工业规模是特别有利的，因为固体形式可以通过使用水作为溶剂，其是无毒溶剂，易于处理并且基本上不需要麻烦的健康或安全预防措施来获得。
-
公开(公告)号：US20230391735A1
公开(公告)日：2023-12-07
申请号：US18039540
申请日：2021-12-01
Applicant: BRACCO IMAGING S.P.A.
Inventor： Roberta FRETTA , Luciano LATTUADA , Gabriele MELI
IPC: C07D257/02
CPC classification number: C07D257/02
Abstract: The invention relates to a process for preparing Gadoteridol of formula (I). In particular, the process comprises the use of propylene oxide in the alkylation step of the compound of formula (II), wherein propylene oxide is directly reacted with the compound of formula (II) without being isolated, and wherein propylene oxide is obtained on demand by decomposition of propylene carbonate in the presence of an alkaline or alkaline earth metal halide as catalyst.
-
公开(公告)号：US20190225570A1
公开(公告)日：2019-07-25
申请号：US16276252
申请日：2019-02-14
Applicant: BRACCO IMAGING S.P.A.
Inventor： Roberta FRETTA , Pietro DELOGU , Fernanda DI GIORGIO , Alfonso NARDELLI , Stefano SGUASSERO , Carlo Felice VISCARDI
IPC: C07C67/08 , C07C67/54 , B01D3/00 , C07C67/287 , C07C51/44
Abstract: The present invention relates to a method for the acetylation of an aqueous solution of lactic acid to (S)-2-acetyloxypropionic acid.The process comprises in particular removing water from the solution of lactic acid and reacting lactic acid with acetic anhydride in the presence of acetic acid.
-
-
-
-
-
-
-
Search Results
8
records
(took 0.013 seconds)
