公开(公告)号：US20240083880A1

公开(公告)日：2024-03-14

申请号：US18388604

申请日：2023-11-10

Applicant: BRACCO IMAGING S.P.A.

Inventor： Francesco BLASI ,  Federica BUONSANTI ,  Federico CRIVELLIN ,  Andrea FERRARIS ,  Laura ORIO ,  Lorena PIZZUTO ,  Roberta NAPOLITANO ,  Giovanni VALBUSA

IPC: C07D403/10 ,  C07D403/14 ,  C09B23/01

CPC classification number: C07D403/10 ,  C07D403/14 ,  C09B23/0066 ,  C09B23/0075

Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof.
The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.

公开(公告)号：US20240131199A1

公开(公告)日：2024-04-25

申请号：US18267590

申请日：2021-12-16

Applicant: BRACCO IMAGING S.P.A. ,  SURGVISION GMBH

Inventor： Roberta NAPOLITANO ,  Francesco BLASI ,  Fulvio FERRETTI ,  Nicolò DIALE ,  Federica BUONSANTI ,  Massimo VISIGALLI ,  Alessia ADAMO

IPC: A61K49/00 ,  C09B23/01 ,  G01N21/64 ,  G01N33/58

CPC classification number: A61K49/0032 ,  C09B23/0066 ,  G01N21/6486 ,  G01N33/582

Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to a class of monoalkylated cyanine dyes with red to near-infrared (650-900 nm) emission characterized by pH responsiveness and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them. The monoalkylated cyanine dyes have general formula (I) wherein R1 and R3 are independently selected from the group consisting of hydrogen, -SO3H, —COOH and —CONH—Y; and R2 and R4 are hydrogen, or both R1 together with R2 and R3 together with R4, respectively and with the atoms to which they are bonded, form two aryl rings, optionally substituted with from 1 to 4 -SO3H groups; R5 is an alkyl optionally substituted by a group selected from —SO3H, —COOH and —CONH2.

公开(公告)号：US20230312523A1

公开(公告)日：2023-10-05

申请号：US18010905

申请日：2021-06-22

Applicant: BRACCO IMAGING S.P.A.

Inventor： Francesco BLASI ,  Federica BUONSANTI ,  Federico CRIVELLIN ,  Andrea FERRARIS ,  Laura ORIO ,  Lorena PIZZUTO ,  Roberta NAPOLITANO ,  Giovanni VALBUSA

IPC: C07D403/10 ,  C07D403/14 ,  C09B23/01

CPC classification number: C07D403/10 ,  C07D403/14 ,  C09B23/0066

Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near- infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them. The compounds have formula (I), formula (I), wherein X is direct bond or —O—; Y is a group selected from linear or branched C1-C6 alkyl, C3-C7 cycloalkyl and heterocyclyl, substituted by at least two hydroxyl groups; R1 and R2 are each independently a linear or branched C1-C6 alkyl substituted by a group selected from —SO3H, —COOH, —CONH2 and — COO—C1-C6 alkyl; and R3 is hydrogen, —SO3H or a linear or branched C1-C6 alkyl substituted by —COOH or —CONH—Y, wherein Y is a group selected from linear or branched C1-C6 alkyl, C3-C7 cycloalkyl and heterocyclyl, substituted by at least two hydroxyl groups.

公开(公告)号：US20250084066A1

公开(公告)日：2025-03-13

申请号：US18958122

申请日：2024-11-25

Applicant: BRACCO IMAGING S.P.A.

Inventor： Francesco BLASI ,  Federica BUONSANTI ,  Federico CRIVELLIN ,  Andrea FERRARIS ,  Laura ORIO ,  Lorena PIZZUTO ,  Roberta NAPOLITANO ,  Giovanni VALBUSA

IPC: C07D403/10 ,  C07D403/14 ,  C09B23/01

Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near-infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.

公开(公告)号：US20220242853A1

公开(公告)日：2022-08-04

申请号：US17610779

申请日：2020-05-12

Applicant: BRACCO IMAGING S.P.A.

Inventor： Francesco BLASI ,  Chiara BRIOSCHI ,  Federica BUONSANTI ,  Luigi MIRAGOLI ,  Roberta NAPOLITANO ,  Laura ORIO ,  Lorena PIZZUTO ,  Giovanni VALBUSA

IPC: C07D403/14 ,  C07D403/06 ,  C07D471/04 ,  C09B23/06 ,  C09B23/08 ,  A61K49/00

Abstract: The present invention relates to the field of optical imaging More particularly, it relates to compounds of the cyanine family characterized by improved physico-chemical and biological properties and to their conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them.